INVOKAMET 1000 MG — DIN 02455455
METFORMIN HYDROCHLORIDE : 1000 MG CANAGLIFLOZIN : 150 MG · JANSSEN INC · TABLET · wholesale supply in Canada
Health Canada status: MARKETED
What is INVOKAMET?
INVOKAMET 1000 MG contains METFORMIN HYDROCHLORIDE : 1000 MG CANAGLIFLOZIN : 150 MG. It is listed in the Health Canada Drug Product Database under DIN 02455455, held by JANSSEN INC, supplied as TABLET for ORAL administration. Health Canada currently lists it as marketed, status dated 28-Jun-2016. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
How much does Metformin And Canagliflozin cost around the world?
Metformin And Canagliflozin is listed on 13 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Bahrain publishes a retail (max). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 6 | 172 | USD███.██ |
| Australia | ex-manufacturer | 33 | 96 | AUD███.██ |
| Czechia | max producer price (ex-factory) | 19 | 96 | CZK███.██ |
| Sweden | AIP (pharmacy purchase price) | 14 | 53 | SEK███.██ |
| Austria | KVP (Kassenverkaufspreis) | 13 | 26 | EUR███.██ |
| Romania | max producer price | 19 | 25 | RON███.██ |
| South Africa | single exit price | 11 | 15 | ZAR███.██ |
| Greece | producer price (ex-factory) | 14 | 14 | EUR███.██ |
| United Kingdom | hospital | 10 | 10 | GBP███.██ |
| Hungary | producer price (ex-factory) | 4 | 5 | HUF███.██ |
| Luxembourg | reimbursement | 5 | 5 | EUR███.██ |
| United Arab Emirates | public | 3 | 3 | AED███.██ |
| Bahrain | retail (max) | 3 | 3 | BHD███.██ |
523 pack listings across 154 brand entries and 12 price bases, refreshed 08 Sep 2026. Ranges span every Metformin And Canagliflozin pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Metformin And Canagliflozin in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
2 holders have a Canadian DIN containing Metformin And Canagliflozin, across 10 DINs, of which 3 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| JANSSEN INC | 9 | 3 | INVOKAMET, INVOKAMET XR | Sourceable in Canada |
| JANSSEN INC 19 Green Belt Drive Toronto Ontario Canada M3C 1L9 | 1 | 0 | INVOKAMET XR | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 1000 MG |
|---|---|
| Dosage form | TABLET |
| Route | ORAL |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Metformin And Canagliflozin |
|---|---|
| ATC code | A10BD16 |
| AHFS class | 84:24.12 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02455455 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2455455 |
| Brand name | INVOKAMET |
| Generic / active ingredient | METFORMIN HYDROCHLORIDE : 1000 MG CANAGLIFLOZIN : 150 MG |
| Market authorization holder | JANSSEN INC |
| Health Canada schedule | Prescription |
| ATC code | A10BD16 |
| ATC anatomical main group | A — Alimentary tract and metabolism |
| ATC therapeutic subgroup | A10BD |
| Current status | MARKETED |
| Status date | 28-Jun-2016 |
| Original market date | 2019-07-22 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
3 of 10 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| INVOKAMET | 50 MG | TABLET | JANSSEN INC | MARKETED | 02455420 |
| INVOKAMET | 50 MG | TABLET | JANSSEN INC | MARKETED | 02455404 |
| INVOKAMET | 500 MG | TABLET | JANSSEN INC | CANCELLED POST MARKET | 02455439 |
| INVOKAMET | 850 MG | TABLET | JANSSEN INC | CANCELLED POST MARKET | 02455447 |
| INVOKAMET | 50 MG | TABLET | JANSSEN INC | CANCELLED POST MARKET | 02455412 |
| INVOKAMET XR | 500 MG | TABLET (EXTENDED-RELEASE) | JANSSEN INC | CANCELLED PRE MARKET | 02477394 |
| INVOKAMET XR | 1000 MG | TABLET (EXTENDED-RELEASE) | JANSSEN INC | CANCELLED PRE MARKET | 02477408 |
| INVOKAMET XR | 500 MG | TABLET (EXTENDED-RELEASE) | JANSSEN INC | CANCELLED PRE MARKET | 02477416 |
| INVOKAMET XR | Strength | Tablet (Extended-Release) | JANSSEN INC 19 Green Belt Drive Toronto Ontario Canada M3C 1L9 | CANCELLED PRE MARKET | 02477424 |
2 · Same class — other molecules in ATC A10BD
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Metformin And Sitagliptin | AG-SITAGLIPTIN HYDROCHLORIDE / METFORMIN · APO-SITAGLIPTIN MALATE / METFORMIN HYDROCHLORIDE · APO-SITAGLIPTIN-METFORMIN · APO-SITAGLIPTIN/METFORMIN XR · +19 more | 63 | 46 | Yes |
| Metformin And Dapagliflozin | APO-DAPAGLIFLOZIN-METFORMIN · AURO-DAPAGLIFLOZIN / METFORMIN · XIGDUO | 6 | 6 | Yes |
| Metformin And Empagliflozin | SYNJARDY | 6 | 6 | Yes |
| Metformin And Canagliflozin | INVOKAMET · INVOKAMET XR | 10 | 3 | Yes |
| Metformin And Alogliptin | KAZANO | 3 | 3 | Yes |
| Metformin And Linagliptin | JENTADUETO | 3 | 3 | Yes |
| Metformin And Rosiglitazone | AVANDAMET · PMS-ROSIGLITAZONE-METFORMIN | 10 | 0 | Not in Canada |
| Combinations Of Oral Blood Glucose Lowering Drugs | SEGLUROMET · STEGLUJAN | 6 | 0 | Not in Canada |
| Pioglitazone And Alogliptin | OSENI | 6 | 0 | Not in Canada |
| Metformin And Saxagliptin | KOMBOGLYZE | 3 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC A10B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| A10BH | Alogliptin · Linagliptin · Saxagliptin · Sitagliptin | 91 | 63 |
| A10BA | Metformin | 122 | 45 |
| A10BK | Canagliflozin · Dapagliflozin · Empagliflozin · Ertugliflozin | 42 | 30 |
| A10BX | Nateglinide · Repaglinide · Tirzepatide | 54 | 30 |
| A10BB | Acetohexamide · Chlorpropamide · Glibenclamide · Gliclazide · Glimepiride · +1 more | 112 | 23 |
| A10BG | Pioglitazone · Rosiglitazone | 98 | 15 |
| A10BJ | Albiglutide · Dulaglutide · Exenatide · Liraglutide · Lixisenatide · +1 more | 34 | 13 |
| A10BF | Acarbose | 6 | 2 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is INVOKAMET called?
Also recorded in Canada as: 24 HR metformin hydrochloride 1000 MG / saxagliptin 2.5 MG Extended Release Oral Tablet [Kombiglyze] (US), 24 HR metformin hydrochloride 1000 MG / saxagliptin 5 MG Extended Release Oral Tablet [Kombiglyze] (US), 24 HR metformin hydrochloride 500 MG / saxagliptin 5 MG Extended Release Oral Tablet [Kombiglyze] (US), linagliptin 2.5 MG / metformin hydrochloride 1000 MG Oral Tablet [Jentadueto] (US), linagliptin 2.5 MG / metformin hydrochloride 500 MG Oral Tablet [Jentadueto] (US), linagliptin 2.5 MG / metformin hydrochloride 850 MG Oral Tablet [Jentadueto] (US), 24 HR metformin hydrochloride 1000 MG / sitagliptin phosphate 100 MG Extended Release Oral Tablet [Janumet] (US), 24 HR metformin hydrochloride 1000 MG / sitagliptin phosphate 50 MG Extended Release Oral Tablet [Janumet] (US), 24 HR metformin hydrochloride 500 MG / sitagliptin phosphate 50 MG Extended Release Oral Tablet [Janumet] (US), alogliptin 12.5 MG / metformin hydrochloride 1000 MG Oral Tablet [Kazano] (US), alogliptin 12.5 MG / metformin hydrochloride 500 MG Oral Tablet [Kazano] (US), canagliflozin 150 MG / metformin hydrochloride 1000 MG Oral Tablet [Invokamet] (US), canagliflozin 150 MG / metformin hydrochloride 500 MG Oral Tablet [Invokamet] (US), canagliflozin 50 MG / metformin hydrochloride 1000 MG Oral Tablet [Invokamet] (US), canagliflozin 50 MG / metformin hydrochloride 500 MG Oral Tablet [Invokamet] (US).
The same molecule, Metformin And Canagliflozin, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Metformin Sandoz | Latin | Australia, Czechia, Sweden |
| METFORMIN VIATRIS | Latin | Czechia |
| Metformin Accord | Latin | Czechia, Sweden |
| Glucophage | Latin | Czechia, South Africa |
| Metformin Orifarm | Latin | Sweden |
| Metformin Teva | Latin | Czechia, Sweden |
| APX-METFORMIN | Latin | Australia |
| BROTMIN | Latin | Czechia |
| Diaformin Viatris | Latin | Australia |
| Glucophage Xr | Latin | Czechia, South Africa |
| METFORMIN MEDREG | Latin | Czechia |
| METFORMIN MYLAN | Latin | Czechia |
| METFORMIN-WGR | Latin | Australia |
| STADAMET | Latin | Czechia |
| STADAMET NEO | Latin | Czechia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.