ADVIL 12 HOUR 600 MG — DIN 02443562
IBUPROFEN : 600 MG · HALEON CANADA ULC · TABLET (EXTENDED-RELEASE) · wholesale supply in Canada
Health Canada status: MARKETED
What is ADVIL 12 HOUR?
ADVIL 12 HOUR 600 MG contains IBUPROFEN : 600 MG. It is listed in the Health Canada Drug Product Database under DIN 02443562, held by HALEON CANADA ULC, supplied as TABLET (EXTENDED-RELEASE) for ORAL administration. Health Canada currently lists it as marketed, status dated 22-May-2025. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is ADVIL 12 HOUR used for?
Relief of minor aches and pains (muscles, joints, backache, sprains), arthritis, headache, migraine, menstrual pain, toothache, common cold/flu, and fever reduction.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Ibuprofen cost around the world?
Ibuprofen is listed on 16 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Bahrain publishes a retail (max). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 7 | 130 | USD███.██ |
| South Africa | single exit price | 76 | 106 | ZAR███.██ |
| Saudi Arabia | public | 61 | 78 | SAR███.██ |
| United Arab Emirates | public | 38 | 56 | AED███.██ |
| Bahrain | retail (max) | 29 | 44 | BHD███.██ |
| Luxembourg | reimbursement | 32 | 32 | EUR███.██ |
| Sweden | AIP (pharmacy purchase price) | 8 | 25 | SEK███.██ |
| Romania | max producer price | 14 | 23 | RON███.██ |
| Norway | max AUP (pharmacy retail) | 5 | 20 | NOK███.██ |
| Australia | ex-manufacturer | 3 | 15 | AUD███.██ |
| Austria | KVP (Kassenverkaufspreis) | 5 | 10 | EUR███.██ |
| United Kingdom | hospital | 10 | 10 | GBP███.██ |
| Greece | producer price (ex-factory) | 5 | 5 | EUR███.██ |
| Czechia | max producer price (ex-factory) | 3 | 4 | CZK███.██ |
| Iceland | max wholesale | 1 | 2 | ISK███.██ |
| Belgium | public | 1 | 1 | EUR███.██ |
561 pack listings across 298 brand entries and 14 price bases, refreshed 08 Sep 2026. Ranges span every Ibuprofen pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Ibuprofen in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
26 holders have a Canadian DIN containing Ibuprofen, across 143 DINs, of which 46 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| HALEON CANADA ULC | 17 | 15 | ADVIL 12 HOUR, ADVIL ARTHRITIS PAIN, ADVIL CAPLETS, ADVIL EXTRA STRENGTH CAPLETS, ADVIL EXTRA STRENGTH LIQUI-GELS, +12 more | Sourceable in Canada |
| MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC | 22 | 7 | CHILDREN'S MOTRIN, CHILDREN'S MOTRIN CHEWABLE TABLET 50MG, CHILDREN'S MOTRIN CHEWABLE TABLETS, INFANTS' MOTRIN, JUNIOR STRENGTH MOTRIN CAPLETS, +16 more | Sourceable in Canada |
| APOTEX INC | 18 | 7 | APO-IBUPROFEN, APO-IBUPROFEN CAPLET, APO-IBUPROFEN TAB 600MG, EXTRA STRENGTH IBUPROFEN LIQUID FILLED CAPSULES, EXTRA STRENGTH IBUPROFEN LIQUID GEL CAPSULES, +7 more | Sourceable in Canada |
| VITA HEALTH PRODUCTS INC | 13 | 7 | EXTRA STRENGTH IBUPROFEN, EXTRA STRENGTH IBUPROFEN LIQUID CAPSULES, IBUPROFEN, IBUPROFEN CAPLETS, IBUPROFEN CAPLETS 200 MG, +6 more | Sourceable in Canada |
| PHARMASCIENCE INC | 10 | 5 | EXTRA STRENGTH IBUPROFEN, IBUPROFEN, IBUPROFEN CAPLETS, IBUPROFEN LIQUID GELS, IBUPROFEN MUSCLE AND JOINT, +3 more | Sourceable in Canada |
| JAMP PHARMA CORPORATION | 6 | 3 | IBUPROFEN, IBUPROFEN 200 MG, IBUPROFEN 400 MG, IBUPROFEN LIQUID GEL, JAMP IBUPROFEN SUSPENSION, +1 more | Sourceable in Canada |
| PERRIGO INTERNATIONAL | 4 | 1 | CHILDREN'S IBUPROFEN SUSPENSION, IBUPROFEN, IBUPROFEN CAPLETS 200 MG, IBUPROFEN TABLETS 200 MG | Sourceable in Canada |
| JUNO OTC INC | 1 | 1 | IBUPROFEN MINI LIQUID CAPSULES | Sourceable in Canada |
| PFIZER CONSUMER HEALTHCARE A DIVISION OF PFIZER CANADA ULC | 9 | 0 | ADVIL HEADACHE & MIGRAINE PAIN CAPLETS, ADVIL HEADACHE & MIGRAINE PAIN EXTRA STRENGTH CAPLETS, ADVIL HEADACHE & MIGRAINE PAIN TABLETS, ADVIL HEADACHE CAPLETS, ADVIL HEADACHE EXTRA STRENGTH, +4 more | No marketed DIN |
| TEVA CANADA LIMITED | 6 | 0 | EXTRA STRENGTH IBUPROFEN, NOVO-PROFEN, REGULAR IBUPROFEN, TEVA-PROFEN | No marketed DIN |
| PENDOPHARM DIVISION OF PHARMASCIENCE INC | 5 | 0 | CHILDREN'S EUROPROFEN, IBUPROFEN 200 MG, PENDO-IBUPROFEN, PENDO-IBUPROFEN (200MG CAPLET), PENDO-IBUPROFEN ES | No marketed DIN |
| GLAXOSMITHKLINE CONSUMER HEALTHCARE ULC | 4 | 0 | ADVIL GEL CAPLETS, ADVIL HEADACHE & MIGRAINE CAPLETS, ADVIL HEADACHE & MIGRAINE EXTRA STRENGTH, ADVIL HEADACHE & MIGRAINE TABLETS | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 600 MG |
|---|---|
| Dosage form | TABLET (EXTENDED-RELEASE) |
| Route | ORAL |
| Pack configuration (monograph) | Not explicitly detailed in provided text (refers to Dosage Forms, Composition and Packaging section). |
| Storage | Not explicitly detailed in provided text (refers to Storage and Stability section). |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Ibuprofen |
|---|---|
| ATC code | M01AE01 |
| AHFS class | 28:08.04.92 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02443562 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2443562 |
| Brand name | ADVIL 12 HOUR |
| Generic / active ingredient | IBUPROFEN : 600 MG |
| Market authorization holder | HALEON CANADA ULC |
| Health Canada schedule | NON-PRESCRIPTION DRUGS |
| ATC code | M01AE01 |
| ATC anatomical main group | M — Musculo-skeletal system |
| ATC therapeutic subgroup | M01AE |
| Current status | MARKETED |
| Status date | 22-May-2025 |
| Original market date | 2016-08-22 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Tablets/Caplets: 200-400mg. 12 Hour: 600mg. Use lowest effective dose for shortest duration. Do not exceed 1200mg/day unless directed by physician.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Active peptic ulcer; NSAID hypersensitivity; nasal polyps, asthma or anaphylaxis precipitated by ASA/NSAIDs; severe hepatic or renal impairment; heart surgery; SLE; hyperkalemia; 3rd trimester pregnancy.
Warnings and precautions
Serious GI toxicity (bleeding, ulceration); cardiovascular risk (thrombotic events, heart failure); renal toxicity; serious skin reactions (SJS/TEN); aseptic meningitis in SLE patients.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
46 of 143 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| ADVIL ARTHRITIS PAIN | 400 MG | CAPSULE | HALEON CANADA ULC | MARKETED | 02415623 |
| ADVIL CAPLETS | 200 MG | TABLET | HALEON CANADA ULC | MARKETED | 01933531 |
| ADVIL EXTRA STRENGTH CAPLETS | 400 MG | TABLET | HALEON CANADA ULC | MARKETED | 02244577 |
| ADVIL EXTRA STRENGTH LIQUI-GELS | 400 MG | CAPSULE | HALEON CANADA ULC | MARKETED | 02248231 |
| ADVIL LIQUI-GELS | 200 MG | CAPSULE | HALEON CANADA ULC | MARKETED | 02241769 |
| ADVIL MIGRAINE & HEADACHE | 400 MG | CAPSULE | HALEON CANADA ULC | MARKETED | 02560380 |
| ADVIL MINI-GELS | 200 MG | CAPSULE | HALEON CANADA ULC | MARKETED | 02485400 |
| ADVIL MUSCLE AND JOINT | 400 MG | TABLET | HALEON CANADA ULC | MARKETED | 02355701 |
| ADVIL PEDIATRIC DROPS | 40 MG | DROPS | HALEON CANADA ULC | MARKETED | 02242522 |
| ADVIL TABLETS | 200 MG | TABLET | HALEON CANADA ULC | MARKETED | 01933558 |
2 · Same class — other molecules in ATC M01AE
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Ibuprofen | ACTIPROFEN - CAPLET 200MG · ADVIL 12 HOUR · ADVIL ARTHRITIS PAIN · ADVIL CAPLETS · +107 more | 143 | 46 | Yes |
| Naproxen | ALEVE BACK AND BODY PAIN · ALEVE CAPLETS · ALEVE LIQUID GELS · ALEVE NIGHTTIME · +81 more | 125 | 31 | Yes |
| Ibuprofen, Combinations | ADVIL COLD & FLU · ADVIL COLD & SINUS CONVENIENCE PACK · ADVIL COLD & SINUS EXTRA STRENGTH LIQUI-GELS · ADVIL COLD & SINUS LIQUI-GELS · +36 more | 40 | 13 | Yes |
| Naproxen And Esomeprazole | MYLAN-NAPROXEN/ESOMEPRAZOLE MR · VIMOVO | 4 | 4 | Yes |
| Ketoprofen | KETOPROFEN · KETOPROFEN SR · KETOPROFEN SUPPOSITORIES · KETOPROFEN-E · +28 more | 36 | 3 | Yes |
| Tiaprofenic Acid | ALBERT TIAFEN SR · ALBERT TIAFEN TAB 200MG · ALBERT TIAFEN TAB 300MG · APO-TIAPROFENIC TABLETS -300MG · +15 more | 25 | 2 | Yes |
| Flurbiprofen | ANSAID TABLETS 100 MG · ANSAID TABLETS 50 MG · FLURBIPROFEN · FLURBIPROFEN-100 TAB 100MG · +12 more | 19 | 2 | Yes |
| Oxaprozin | APO-OXAPROZIN · DAYPRO · RHOXAL-OXAPROZIN | 3 | 0 | Not in Canada |
| Fenoprofen | NALFON CAP 300MG · NALFON TAB 600MG | 2 | 0 | Not in Canada |
| Naproxen And Diphenhydramine | PAIN RELIEVER & SLEEP AID | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC M01A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| M01AB | Diclofenac · Diclofenac, Combinations · Etodolac · Indometacin · Ketorolac · +2 more | 170 | 38 |
| M01AH | Celecoxib · Rofecoxib | 72 | 30 |
| M01AC | Meloxicam · Piroxicam · Tenoxicam | 67 | 14 |
| M01AG | Mefenamic Acid | 7 | 1 |
| M01AX | Nabumetone | 12 | 1 |
| M01AA | Oxyphenbutazone · Phenylbutazone · Phenylbutazone, Combinations | 7 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is ADVIL 12 HOUR called?
The same molecule, Ibuprofen, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Brufen | Latin | Australia, Bahrain, Czechia, South Africa |
| Ibumax | Latin | Czechia, Norway, Sweden |
| Ibuprofen Zentiva | Latin | Norway, Sweden |
| Ibux | Latin | Norway |
| Deep Relief | Latin | Bahrain, South Africa |
| Ibumetin® | Latin | Sweden |
| Brufen® | Latin | Sweden |
| I-PROFEN | Latin | Bahrain |
| Ibupain | Latin | South Africa |
| Inza | Latin | South Africa |
| Pedea | Latin | Bahrain, Iceland, South Africa |
| Brufen Retard | Latin | Bahrain, Norway, South Africa |
| Ibudorum | Latin | Saudi Arabia |
| IBUGESIC | Latin | Bahrain, Saudi Arabia |
| Ibuprofen B. Braun | Latin | Norway |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.