IOPIDINE 0.5 %
APRACLONIDINE (APRACLONIDINE HYDROCHLORIDE) : 0.5 % · DIN 02076306 · ESSENTIAL PHARMA SWITZERLAND GMBH
Health Canada status: MARKETED
What is IOPIDINE?
IOPIDINE 0.5 % contains APRACLONIDINE (APRACLONIDINE HYDROCHLORIDE) : 0.5 %. It is listed in the Health Canada Drug Product Database under DIN 02076306, held by ESSENTIAL PHARMA SWITZERLAND GMBH, supplied as SOLUTION for OPHTHALMIC administration. Health Canada currently lists it as marketed, status dated 19-May-2023. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
Product details and regulatory record
| DIN | 02076306 |
|---|---|
| Brand name | IOPIDINE |
| Generic / active ingredient | APRACLONIDINE (APRACLONIDINE HYDROCHLORIDE) : 0.5 % |
| Manufacturer | ESSENTIAL PHARMA SWITZERLAND GMBH |
| Strength | 0.5 % |
| Dosage form | SOLUTION |
| Route of administration | OPHTHALMIC |
| Schedule | Prescription |
| ATC code | S01EA03 APRACLONIDINE |
| Biosimilar | No |
| Health Canada status | MARKETED |
| Status date | 19-May-2023 |
How is this product identified?
Purchase orders, customs paperwork and tender documents each ask for a different identifier, and a DIN written without its leading zeros is the single most common reason an order line fails to match. Every form Nexara accepts for this product is listed here.
| DIN (8-digit, as used in Nexara ordering) | 02076306 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2076306 |
| Brand name | IOPIDINE |
| Active ingredient / INN | APRACLONIDINE (APRACLONIDINE HYDROCHLORIDE) : 0.5 % |
| ATC code | S01EA03 |
| ATC anatomical main group | S — Sensory organs |
| ATC therapeutic subgroup | S01 |
| Health Canada schedule | Prescription |
| Biosimilar biologic | No |
| Market authorization holder | ESSENTIAL PHARMA SWITZERLAND GMBH |
Which pack is which?
| Strength on the label | 0.5 % |
|---|---|
| Dosage form | SOLUTION |
| Route | OPHTHALMIC |
One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced. Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
What can be used instead?
Other Canadian products sharing ATC code S01EA03 APRACLONIDINE. 2 of 2 DINs in this group are currently marketed — marketed products are listed first, because that is what can actually be bought. These tables describe supply, not clinical equivalence: substitution rests with the prescriber or pharmacist, and interchangeability is determined provincially.
| Product | Strength | Form | Manufacturer | Health Canada status | DIN |
|---|---|---|---|---|---|
| IOPIDINE | 1 % | SOLUTION | ESSENTIAL PHARMA SWITZERLAND GMBH | MARKETED | DIN 00888354 |
Who else supplies APRACLONIDINE worldwide?
Nexara tracks national medicine registries and published price lists across multiple markets. APRACLONIDINE appears in 8 registered pack listings across 6 markets, published on 6 different national price bases. Where a Canadian route is closed, that is where an alternative route of supply starts — subject to the import rules in both countries.
Registered listings are not stock. Ask us to confirm what can actually be sourced for your order.
How much does APRACLONIDINE cost around the world?
APRACLONIDINE is listed on 5 national price registers Nexara tracks, across 11 pack listings published on 5 different price bases. What each country publishes is set out below.
| Market | What that country publishes | Brands listed | Pack listings | As of |
|---|---|---|---|---|
| Morocco | PPV (public price) | 1 | 4 | 05 Sep 2026 |
| Iceland | max wholesale | 1 | 2 | 02 Sep 2026 |
| United States | acquisition | 1 | 2 | 03 Sep 2026 |
| South Africa | single exit price | 2 | 2 | 01 Sep 2026 |
| Saudi Arabia | public | 1 | 1 | 01 Sep 2026 |
Why there are no figures here. These bases are not comparable. A Brazilian ex-factory ceiling, a Belgian pharmacy public price and a Japanese reimbursement rate answer three different questions, and none of them is what a product lands in Canada for. Putting them side by side would mislead in both directions, so Nexara publishes where a molecule is listed and on what basis, and quotes the delivered Canadian price per order.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.