PDP-AMANTADINE HYDROCHLORIDE SYRUP 50 MG / 5 ML — DIN 02022826
AMANTADINE HYDROCHLORIDE : 50 MG / 5 ML · PENDOPHARM DIVISION OF PHARMASCIENCE INC · SYRUP · wholesale supply in Canada
Health Canada status: MARKETED
What is PDP-AMANTADINE HYDROCHLORIDE SYRUP?
PDP-AMANTADINE HYDROCHLORIDE SYRUP 50 MG / 5 ML contains AMANTADINE HYDROCHLORIDE : 50 MG / 5 ML. It is listed in the Health Canada Drug Product Database under DIN 02022826, held by PENDOPHARM DIVISION OF PHARMASCIENCE INC, supplied as SYRUP for ORAL administration. Health Canada currently lists it as marketed, status dated 05-Jan-2018. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is PDP-AMANTADINE HYDROCHLORIDE SYRUP used for?
pdp - AMANTADINE HYDROCHLORIDE is useful in the treatment of Parkinson's Syndrome and in the short-term management of drug-induced extrapyramidal symptoms. It is also used for the prevention or chemoprophylaxis of respiratory tract infections caused by Influenza A virus strains, especially in high-risk patients, and the treatment of uncomplicated respiratory tract illness caused by Influenza A virus strains.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Amantadine cost around the world?
Amantadine is listed on 5 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Greece publishes a producer price (ex-factory); Iceland publishes a max wholesale. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 3 | 34 | USD███.██ |
| Australia | ex-manufacturer | 2 | 4 | AUD███.██ |
| Iceland | max wholesale | 1 | 2 | ISK███.██ |
| Greece | producer price (ex-factory) | 1 | 1 | EUR███.██ |
| South Africa | single exit price | 1 | 1 | ZAR███.██ |
42 pack listings across 8 brand entries and 5 price bases, refreshed 08 Sep 2026. Ranges span every Amantadine pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Amantadine in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
9 holders have a Canadian DIN containing Amantadine, across 14 DINs, of which 3 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| PENDOPHARM DIVISION OF PHARMASCIENCE INC | 2 | 2 | PDP-AMANTADINE HYDROCHLORIDE CAPSULES, PDP-AMANTADINE HYDROCHLORIDE SYRUP | Sourceable in Canada |
| ODAN LABORATORIES LTD | 1 | 1 | ODAN-AMANTADINE SYRUP | Sourceable in Canada |
| BRISTOL-MYERS SQUIBB CANADA | 3 | 0 | ENDANTADINE, SYMMETREL CAPSULES 100MG, SYMMETREL SYRUP 10MG/ML | No marketed DIN |
| PHARMASCIENCE INC | 2 | 0 | PMS-AMANTADINE HYDROCHLORIDE CAPSULES, PMS-AMANTADINE HYDROCHLORIDE SYRUP | No marketed DIN |
| PHARMEL INC | 2 | 0 | PHL-AMANTADINE, PHL-AMANTADINE SYRUP 10MG/ML | No marketed DIN |
| DOMINION PHARMACAL | 1 | 0 | DOM-AMANTADINE HYDROCHLORIDE CAPSULES-100MG | No marketed DIN |
| DUPONT MERCK PHARMA INC. | 1 | 0 | ENDANTADINE CAP 100MG | No marketed DIN |
| MEDICAN PHARMA INCORPORATED 203 1120 Victoria St North Kitchener Ontario Canada N2B 3T2 | 1 | 0 | MED-AMANTIDINE - CAP 100MG | No marketed DIN |
| MYLAN PHARMACEUTICALS ULC | 1 | 0 | MYLAN-AMANTADINE | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 50 MG / 5 ML |
|---|---|
| Dosage form | SYRUP |
| Route | ORAL |
| Pack configuration (monograph) | Capsules: Bottles of 100 capsules. Syrup: Bottles of 500 mL. |
| Storage | null |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation, because this listing covers more than one of them.
Substance and classification
| Active substance | Amantadine |
|---|---|
| ATC code | N04BB01 |
| AHFS class | 08:18.04 ; 28:36.04 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02022826 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2022826 |
| Brand name | PDP-AMANTADINE HYDROCHLORIDE SYRUP |
| Generic / active ingredient | AMANTADINE HYDROCHLORIDE : 50 MG / 5 ML |
| Market authorization holder | PENDOPHARM DIVISION OF PHARMASCIENCE INC |
| Health Canada schedule | Prescription |
| ATC code | N04BB01 |
| ATC anatomical main group | N — Nervous system |
| ATC therapeutic subgroup | N04BB |
| Current status | MARKETED |
| Status date | 05-Jan-2018 |
| Original market date | 1993-12-31 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Parkinson's: Initially 100 mg/day, increasing to 100 mg BID. Max 400 mg/day. Influenza A: Adults 200 mg/day (single or split dose). Adjust for renal impairment. Withdraw gradually.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity to amantadine or any ingredient; renal impairment with creatinine clearance < 15 mL/min.
Warnings and precautions
Do not discontinue abruptly (risk of Neuroleptic Malignant Syndrome). Monitor for suicidality, psychosis, impulse control disorders, seizures, and peripheral edema. May impair driving skills.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
3 of 14 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| ODAN-AMANTADINE SYRUP | 10 MG | SYRUP | ODAN LABORATORIES LTD | MARKETED | 02538601 |
| PDP-AMANTADINE HYDROCHLORIDE CAPSULES | 100 MG | CAPSULE | PENDOPHARM DIVISION OF PHARMASCIENCE INC | MARKETED | 01990403 |
| DOM-AMANTADINE HYDROCHLORIDE CAPSULES-100MG | 100 MG | CAPSULE | DOMINION PHARMACAL | CANCELLED POST MARKET | 02130963 |
| ENDANTADINE | 100 MG | CAPSULE | BRISTOL-MYERS SQUIBB CANADA | CANCELLED POST MARKET | 02034468 |
| ENDANTADINE CAP 100MG | 100 MG | CAPSULE | DUPONT MERCK PHARMA INC. | CANCELLED POST MARKET | 01919288 |
| MED-AMANTIDINE - CAP 100MG | Strength | Capsule | MEDICAN PHARMA INCORPORATED 203 1120 Victoria St North Kitchener Ontario Canada N2B 3T2 | CANCELLED POST MARKET | 02199289 |
| MYLAN-AMANTADINE | 100 MG | CAPSULE | MYLAN PHARMACEUTICALS ULC | CANCELLED POST MARKET | 02139200 |
| PHL-AMANTADINE | 100 MG | CAPSULE | PHARMEL INC | CANCELLED POST MARKET | 02238306 |
| PHL-AMANTADINE SYRUP 10MG/ML | 10 MG | SYRUP | PHARMEL INC | CANCELLED POST MARKET | 02262649 |
| PMS-AMANTADINE HYDROCHLORIDE CAPSULES | 100 MG | CAPSULE | PHARMASCIENCE INC | CANCELLED PRE MARKET | 02494140 |
2 · Same class — other molecules in ATC N04BB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Amantadine | DOM-AMANTADINE HYDROCHLORIDE CAPSULES-100MG · ENDANTADINE · ENDANTADINE CAP 100MG · MED-AMANTIDINE - CAP 100MG · +10 more | 14 | 3 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC N04B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| N04BC | Apomorphine · Bromocriptine · Pergolide · Pramipexole · Ropinirole · +1 more | 135 | 45 |
| N04BA | Foslevodopa And Decarboxylase Inhibitor · Levodopa And Decarboxylase Inhibitor · Levodopa,Decarboxylase Inhibitor, And Comt Inhibitor | 57 | 29 |
| N04BD | Rasagiline · Safinamide · Selegiline | 27 | 11 |
| N04BX | Entacapone · Tolcapone | 9 | 3 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is PDP-AMANTADINE HYDROCHLORIDE SYRUP called?
The same molecule, Amantadine, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Amantadine Hydrochloride | Latin | Iceland |
| AMANTAMED | Latin | Australia |
| Symmetrel | Latin | South Africa |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.