KINLYTIC OPEN-CATH 5000 UNIT
UROKINASE : 5000 UNIT · DIN 00886777 · MICROBIX BIOSYSTEMS INC
Health Canada status: CANCELLED POST MARKET
What is KINLYTIC OPEN-CATH?
KINLYTIC OPEN-CATH 5000 UNIT contains UROKINASE : 5000 UNIT. It is listed in the Health Canada Drug Product Database under DIN 00886777, held by MICROBIX BIOSYSTEMS INC, supplied as POWDER FOR SOLUTION for INTRAVENOUS administration. Health Canada currently lists it as cancelled post market, status dated 28-Oct-2009. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is KINLYTIC OPEN-CATH used for?
KINLYTIC® OPEN-CATH® (urokinase for catheter clearance) is indicated for the restoration of patency to intravenous catheters, including central venous catheters, obstructed by clotted blood or fibrin.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
Product details and regulatory record
| DIN | 00886777 |
|---|---|
| Brand name | KINLYTIC OPEN-CATH |
| Generic / active ingredient | UROKINASE : 5000 UNIT |
| Manufacturer | MICROBIX BIOSYSTEMS INC |
| Strength | 5000 UNIT |
| Dosage form | POWDER FOR SOLUTION |
| Route of administration | INTRAVENOUS |
| Schedule | Schedule D |
| ATC code | B01AD04 UROKINASE |
| AHFS class | 20:12.20 |
| Biosimilar | No |
| Health Canada status | CANCELLED POST MARKET |
| Status date | 28-Oct-2009 |
| Original market date | 1991-12-31 00:00:00 |
How is it administered?
Instill 1 mL or 1.8 mL (5000 IU/mL) into occluded catheter. Wait 5-30 mins, then aspirate. May repeat if necessary. Aspirate 4-5 mL blood after patency restored to remove drug/clot residue.
Included because it drives pack selection and wastage. Consult the monograph.
How is it stored and handled?
Store powder below 25°C. Avoid freezing.
How is it supplied?
5,000 IU DIL-U-VIAL* (1 mL when mixed with diluent in upper chamber) and 9,000 IU DIL-U-VIAL* (1.8 mL when mixed with diluent in upper chamber) providing 5,000 IU of urokinase activity per mL
Contraindications
Hypersensitivity to urokinase; active internal bleeding, history of CVA, recent intracranial/intraspinal surgery, recent trauma, intracranial neoplasm, severe hypertension, aortic dissection.
Warnings and precautions
Potential risk of transmitting infectious agents (human cell source). Avoid excessive pressure during injection to prevent catheter rupture or clot expulsion. Not effective for non-fibrin occlusions.
What can be used instead?
Other Canadian products sharing ATC code B01AD04 UROKINASE. 0 of 2 DINs in this group are currently marketed — marketed products are listed first, because that is what can actually be bought. These tables describe supply, not clinical equivalence: substitution rests with the prescriber or pharmacist, and interchangeability is determined provincially.
| Product | Strength | Form | Manufacturer | Health Canada status | DIN |
|---|---|---|---|---|---|
| KINLYTIC (UROKINASE FOR INJECTION) | 250000 UNIT | POWDER FOR SOLUTION | MICROBIX BIOSYSTEMS INC | CANCELLED POST MARKET | DIN 00749702 |
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.