KINLYTIC (UROKINASE FOR INJECTION) 250000 UNIT — DIN 00749702
UROKINASE : 250000 UNIT · MICROBIX BIOSYSTEMS INC · POWDER FOR SOLUTION · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is KINLYTIC (UROKINASE FOR INJECTION)?
KINLYTIC (UROKINASE FOR INJECTION) 250000 UNIT contains UROKINASE : 250000 UNIT. It is listed in the Health Canada Drug Product Database under DIN 00749702, held by MICROBIX BIOSYSTEMS INC, supplied as POWDER FOR SOLUTION for INTRAVENOUS administration. Health Canada currently lists it as cancelled post market, status dated 28-Oct-2009. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
What is KINLYTIC (UROKINASE FOR INJECTION) used for?
Lysis of acute massive pulmonary emboli; coronary artery thrombosis; peripheral arterial and graft thromboembolic occlusion; restoration of patency to intravenous catheters.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
Is there a generic Urokinase in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
Only one market authorization holder has a Canadian DIN containing Urokinase — 2 DINs, of which 0 are currently marketed. There is no second Canadian source today, so a supply interruption on this holder has no domestic substitute at the same molecule.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| MICROBIX BIOSYSTEMS INC | 2 | 0 | KINLYTIC (UROKINASE FOR INJECTION), KINLYTIC OPEN-CATH | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 250000 UNIT |
|---|---|
| Dosage form | POWDER FOR SOLUTION |
| Route | INTRAVENOUS |
| Pack configuration (monograph) | Vials containing 250,000 IU or 1,000,000 IU of urokinase. Also available as KINLYTIC OPEN-CATH in 5,000 IU or 9,000 IU vials. |
| Storage | Store powder at 2° - 30°C. Reconstitute immediately before use; contains no preservatives. |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Urokinase |
|---|---|
| ATC code | B01AD04 |
| AHFS class | 20:12.20 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 00749702 |
|---|---|
| DIN (unpadded, as printed on some documents) | 749702 |
| Brand name | KINLYTIC (UROKINASE FOR INJECTION) |
| Generic / active ingredient | UROKINASE : 250000 UNIT |
| Market authorization holder | MICROBIX BIOSYSTEMS INC |
| Health Canada schedule | Schedule D |
| ATC code | B01AD04 |
| ATC anatomical main group | B — Blood and blood-forming organs |
| ATC therapeutic subgroup | B01AD |
| Current status | CANCELLED POST MARKET |
| Status date | 28-Oct-2009 |
| Original market date | 1988-12-31 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Pulmonary Embolism: 4,400 IU/kg priming dose over 10 min, then 4,400 IU/kg/hr for 12 hours. Also used for coronary artery thrombi, peripheral arterial occlusion, and I.V. catheter clearance.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Active internal bleeding, history of CVA, recent intracranial/intraspinal surgery or trauma, intracranial neoplasm, aneurysm, bleeding diathesis, severe uncontrolled hypertension, aortic dissection.
Warnings and precautions
Potential for transmission of infectious agents (human source material). High risk of bleeding; avoid invasive procedures. Monitor for cholesterol embolization and reperfusion arrhythmias.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
0 of 2 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| KINLYTIC OPEN-CATH | 5000 UNIT | POWDER FOR SOLUTION | MICROBIX BIOSYSTEMS INC | CANCELLED POST MARKET | 00886777 |
2 · Same class — other molecules in ATC B01AD
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Alteplase | ACTIVASE RT-PA · ACTIVASE RT-PA INJ · CATHFLO · LYSATEC RT - PA | 5 | 3 | Yes |
| Tenecteplase | TNKASE | 1 | 1 | Yes |
| Streptokinase | KABIKINASE - PWS 1500000UNITS/VIAL · KABIKINASE - PWS 250000 UNIT/VIAL · KABIKINASE - PWS 750000UNITS/VIAL · STREPTASE · +3 more | 9 | 0 | Not in Canada |
| Urokinase | KINLYTIC (UROKINASE FOR INJECTION) · KINLYTIC OPEN-CATH | 2 | 0 | Not in Canada |
| Drotrecogin Alfa | XIGRIS (20MG/VIAL) · XIGRIS (5MG/VIAL) | 2 | 0 | Not in Canada |
| Reteplase | RETAVASE | 1 | 0 | Not in Canada |
| Anistreplase | EMINASE 30 UNITS | 1 | 0 | Not in Canada |
| Ancrod | VIPRINEX | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC B01A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| B01AF | Apixaban · Edoxaban · Rivaroxaban | 159 | 121 |
| B01AB | Antithrombin · Dalteparin · Danaparoid · Enoxaparin · Heparin · +3 more | 128 | 82 |
| B01AC | Abciximab · Acetylsalicylic Acid · Cangrelor · Clopidogrel · Combinations · +10 more | 158 | 66 |
| B01AA | Acenocoumarol · Warfarin | 62 | 16 |
| B01AE | Argatroban · Bivalirudin · Dabigatran Etexilate · Lepirudin | 18 | 11 |
| B01AX | Caplacizumab · Defibrotide · Fondaparinux | 10 | 5 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.