DIACETYLMORPHINE HYDROCHLORIDE 5000 MG — DIN 02525003
DIAMORPHINE HYDROCHLORIDE : 5000 MG · PHARMASCIENCE INC · POWDER FOR SOLUTION · wholesale supply in Canada
Health Canada status: MARKETED
What is DIACETYLMORPHINE HYDROCHLORIDE?
DIACETYLMORPHINE HYDROCHLORIDE 5000 MG contains DIAMORPHINE HYDROCHLORIDE : 5000 MG. It is listed in the Health Canada Drug Product Database under DIN 02525003, held by PHARMASCIENCE INC, supplied as POWDER FOR SOLUTION for INTRAMUSCULAR ; INTRAVENOUS administration. Health Canada currently lists it as marketed, status dated 11-Apr-2022. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is DIACETYLMORPHINE HYDROCHLORIDE used for?
Supervised injectable opioid agonist therapy (siOAT) for adults with severe opioid use disorder who use injectable opioids and have failed previous OAT attempts (e.g., methadone).
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
Is there a generic Diamorphine in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
2 holders have a Canadian DIN containing Diamorphine, across 4 DINs, of which 2 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| PHARMASCIENCE INC | 2 | 2 | DIACETYLMORPHINE HYDROCHLORIDE | Sourceable in Canada |
| TECHNILAB PHARMA INC. | 2 | 0 | DIAMORPHINE HYDROCHLORIDE INJ 100MG/ML BP, DIAMORPHINE HYDROCHLORIDE INJ 30MG/ML BP | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 5000 MG |
|---|---|
| Dosage form | POWDER FOR SOLUTION |
| Route | INTRAMUSCULAR ; INTRAVENOUS |
| Pack configuration (monograph) | 200 mg vials (boxes of 10); 5 g vials (boxes of 1). |
| Storage | Reconstituted solution in syringes: refrigerated (2-8°C) for up to 14 days, or at 25°C for up to 48 hours. Reconstituted solution in EVA bags: up to 3 hours. |
| Shipping class | Cold chain — validated shipper with temperature monitoring |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Cold chain. This product is stored refrigerated. Nexara ships it on a validated cold chain with temperature monitoring; a delivery address that cannot receive and store it at 2–8 °C on arrival must be flagged before the order is placed.
Substance and classification
| Active substance | Diamorphine |
|---|---|
| ATC code | N07BC06 |
| AHFS class | 28:08.08 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02525003 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2525003 |
| Brand name | DIACETYLMORPHINE HYDROCHLORIDE |
| Generic / active ingredient | DIAMORPHINE HYDROCHLORIDE : 5000 MG |
| Market authorization holder | PHARMASCIENCE INC |
| Health Canada schedule | NARCOTICS (CDSA I) |
| ATC code | N07BC06 |
| ATC anatomical main group | N — Nervous system |
| ATC therapeutic subgroup | N07BC |
| Current status | MARKETED |
| Status date | 11-Apr-2022 |
| Original market date | 2022-04-11 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Individualized titration. Max single dose 400 mg; max daily dose 1000 mg. Administered via supervised IV or IM self-injection. Monitor for 30 mins post-injection.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity to opioids; no opioid use disorder; GI obstruction; asthma/COPD; acute respiratory depression; acute alcoholism; convulsive disorders; severe CNS depression; MAOI use; intoxication.
Warnings and precautions
Serious risk of fatal respiratory depression, addiction, abuse, and misuse. Risk of overdose if combined with benzodiazepines or alcohol. Seizure risk. Never inject into jugular or femoral veins.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
2 of 4 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| DIACETYLMORPHINE HYDROCHLORIDE | 200 MG | POWDER FOR SOLUTION | PHARMASCIENCE INC | MARKETED | 02524996 |
| DIAMORPHINE HYDROCHLORIDE INJ 100MG/ML BP | 100 MG | POWDER FOR SOLUTION | TECHNILAB PHARMA INC. | CANCELLED POST MARKET | 00781460 |
| DIAMORPHINE HYDROCHLORIDE INJ 30MG/ML BP | 30 MG | POWDER FOR SOLUTION | TECHNILAB PHARMA INC. | CANCELLED POST MARKET | 00781479 |
2 · Same class — other molecules in ATC N07BC
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Methadone | APO-METHADONE · JAMP METHADONE ORAL CONCENTRATE · METADOL · METADOL-D · +5 more | 28 | 19 | Yes |
| Buprenorphine, Combinations | MYLAN-BUPRENORPHINE/NALOXONE · PMS-BUPRENORPHINE-NALOXONE · SUBOXONE · TARO-BUPRENORPHINE/NALOXONE · +1 more | 16 | 12 | Yes |
| Diamorphine | DIACETYLMORPHINE HYDROCHLORIDE · DIAMORPHINE HYDROCHLORIDE INJ 100MG/ML BP · DIAMORPHINE HYDROCHLORIDE INJ 30MG/ML BP | 4 | 2 | Yes |
| Buprenorphine | PROBUPHINE · SUBLOCADE | 3 | 2 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC N07B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| N07BA | Nicotine · Varenicline | 31 | 13 |
| N07BB | Acamprosate · Calcium Carbimide · Disulfiram · Naltrexone | 10 | 4 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.