MAR-TRIENTINE 250 MG

What is MAR-TRIENTINE?

MAR-TRIENTINE 250 MG contains TRIENTINE HYDROCHLORIDE : 250 MG. It is listed in the Health Canada Drug Product Database under DIN 02504855, held by MARCAN PHARMACEUTICALS INC, supplied as CAPSULE for ORAL administration. Health Canada currently lists it as marketed, status dated 10-Nov-2020. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.

What is MAR-TRIENTINE used for?

MAR-Trientine (trientine hydrochloride) is indicated for the treatment of patients with Wilson's Disease who are intolerant to penicillamine. MAR-Trientine should only be initiated by physicians experienced in the management of Wilson's Disease.

Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.

Product details and regulatory record

How is it administered?

Adults: The recommended starting dose of MAR-Trientine is 750 mg/day, given in divided doses 2 to 4 times a day. Subsequently, if required, the daily dose may be increased gradually to a maximum of 2,000 mg/day. Most adult patients can be maintained at a daily dose of 1,250 mg/day or less. Pediatrics (5-17 years old): The recommended starting dose is 500 mg/day, given in divided doses 2 to 4 times a day. Subsequently, if required, the daily dose may be increased gradually to a maximum of 1,500 mg/day for patients aged 12 years or under. The daily dose of MAR-Trientine should be increased only when the clinical response is not adequate or the concentration of serum free copper is persistently above 3.1 µmol/L (20 μg/dL). The optimal long-term maintenance dosage should generally be determined at 6 to 12 month intervals. MAR-Trientine should be given on an empty stomach, at least one hour before meals or two hours after meals and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed. Missed Dose: A missed dose should be administered as soon as possible. However, two doses of MAR-Trientine should not be taken at the same time or very close to each other. If it is almost time for your next dose, skip the missed dose and continue with your next scheduled dose. Go back to the regular dosing schedule. Do not take two doses at the same time.

Included because it drives pack selection and wastage. Consult the monograph.

How is it stored and handled?

Keep container tightly closed. Store at 15° to 30°C. Keep in a safe place out of reach and sight of children.

How is it supplied?

MAR-Trientine, USP 250 mg, white to pale yellow powder filled in Size 1 hard gelatin capsule with brown opaque cap imprinted with “HP551" in black ink and brown opaque body imprinted with "HP551" in black ink. They are supplied in bottles of 100's.

Contraindications

MAR-Trientine is contraindicated in patients who are hypersensitive to this drug or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container.

Warnings and precautions

MAR-Trientine (trientine hydrochloride) should only be initiated by physicians experienced in the management of Wilson's Disease. Worsening of neurologic or neurocognitive functioning, which can be irreversible, may occur in patients with pre-existing neurologic and/or neuropsychiatric impairment due to Wilson's Disease and treated with MAR-Trientine. Close monitoring of clinical response in these patients is required in the first few months following initiation of MAR-Trientine. Overtreatment carries the risk of copper deficiency, which is especially harmful for children and pregnant women, since copper is required for proper growth and mental development. Therefore, ongoing regular monitoring for manifestations of overtreatment should be undertaken. Trientine hydrochloride is a chelating agent that has been found to reduce serum iron levels, which may lead to iron deficiency anemia. Oral iron supplementation may be necessary, and if required, it should be administered at a different time of day than MAR-Trientine. Because of the potential for contact dermatitis, any exposure to the capsule contents should be washed promptly with water.

What can be used instead?

Other Canadian products sharing ATC code A16AX12 TRIENTINE. 2 of 2 DINs in this group are currently marketed — marketed products are listed first, because that is what can actually be bought. These tables describe supply, not clinical equivalence: substitution rests with the prescriber or pharmacist, and interchangeability is determined provincially.

Who else supplies TRIENTINE worldwide?

Nexara tracks national medicine registries and published price lists across multiple markets. TRIENTINE appears in 21 registered pack listings across 9 markets, published on 6 different national price bases. Where a Canadian route is closed, that is where an alternative route of supply starts — subject to the import rules in both countries.

Registered listings are not stock. Ask us to confirm what can actually be sourced for your order.