TARO-PEMETREXED 1000 MG — DIN 02480492
PEMETREXED (PEMETREXED DISODIUM) : 1000 MG · TARO PHARMACEUTICALS INC · POWDER FOR SOLUTION · wholesale supply in Canada
Health Canada status: MARKETED
What is TARO-PEMETREXED?
TARO-PEMETREXED 1000 MG contains PEMETREXED (PEMETREXED DISODIUM) : 1000 MG. It is listed in the Health Canada Drug Product Database under DIN 02480492, held by TARO PHARMACEUTICALS INC, supplied as POWDER FOR SOLUTION for INTRAVENOUS administration. Health Canada currently lists it as marketed, status dated 07-May-2021. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is TARO-PEMETREXED used for?
Malignant pleural mesothelioma (with cisplatin); First-line, maintenance, or second-line treatment of locally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC).
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Pemetrexed cost around the world?
Pemetrexed is listed on 13 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Bahrain publishes a retail (max); Czechia publishes a max producer price (ex-factory). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Italy | ex-factory (classe H) | 15 | 24 | EUR███.██ |
| Saudi Arabia | public | 14 | 20 | SAR███.██ |
| Greece | producer price (ex-factory) | 18 | 18 | EUR███.██ |
| Romania | max producer price | 13 | 17 | RON███.██ |
| South Africa | single exit price | 17 | 17 | ZAR███.██ |
| United Kingdom | hospital | 13 | 13 | GBP███.██ |
| Hungary | producer price (ex-factory) | 7 | 12 | HUF███.██ |
| Australia | ex-manufacturer | 5 | 10 | AUD███.██ |
| Czechia | max producer price (ex-factory) | 3 | 7 | CZK███.██ |
| Slovakia | categorised final price | 3 | 7 | EUR███.██ |
| Bahrain | retail (max) | 4 | 5 | BHD███.██ |
| Iceland | max wholesale | 2 | 4 | ISK███.██ |
| Morocco | PPV (public price) | 1 | 3 | MAD███.██ |
157 pack listings across 115 brand entries and 12 price bases, refreshed 08 Sep 2026. Ranges span every Pemetrexed pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Pemetrexed in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
15 holders have a Canadian DIN containing Pemetrexed, across 36 DINs, of which 14 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| ACCORD HEALTHCARE INC | 3 | 3 | PEMETREXED DISODIUM FOR INJECTION, PEMETREXED FOR INJECTION | Sourceable in Canada |
| TARO PHARMACEUTICALS INC | 3 | 3 | TARO-PEMETREXED | Sourceable in Canada |
| AURO PHARMA INC | 3 | 2 | PEMETREXED DISODIUM FOR INJECTION | Sourceable in Canada |
| EUGIA PHARMA INC. | 3 | 2 | PEMETREXED DISODIUM FOR INJECTION | Sourceable in Canada |
| DR REDDY'S LABORATORIES LTD | 2 | 2 | PEMETREXED FOR INJECTION, USP | Sourceable in Canada |
| TEVA CANADA LIMITED | 2 | 2 | PEMETREXED DISODIUM FOR INJECTION | Sourceable in Canada |
| ACTAVIS PHARMA COMPANY | 3 | 0 | ACT PEMETREXED | No marketed DIN |
| PFIZER CANADA ULC | 3 | 0 | PEMETREXED DISODIUM FOR INJECTION | No marketed DIN |
| SANDOZ CANADA INCORPORATED | 3 | 0 | PEMETREXED DISODIUM FOR INJECTION | No marketed DIN |
| APOTEX INC | 2 | 0 | PEMETREXED | No marketed DIN |
| ELI LILLY CANADA INC | 2 | 0 | ALIMTA | No marketed DIN |
| MARCAN PHARMACEUTICALS INC | 2 | 0 | PEMETREXED DISODIUM FOR INJECTION, PEMETREXED DISODIUM FOR INJECTION USP | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 1000 MG |
|---|---|
| Dosage form | POWDER FOR SOLUTION |
| Route | INTRAVENOUS |
| Pack configuration (monograph) | 100 mg, 500 mg, or 1,000 mg pemetrexed (as pemetrexed disodium) per vial. |
| Storage | Not explicitly detailed in the provided text summary (refer to full STORAGE AND STABILITY section 16). |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Pemetrexed |
|---|---|
| ATC code | L01BA04 |
| AHFS class | 10:00.00 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02480492 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2480492 |
| Brand name | TARO-PEMETREXED |
| Generic / active ingredient | PEMETREXED (PEMETREXED DISODIUM) : 1000 MG |
| Market authorization holder | TARO PHARMACEUTICALS INC |
| Health Canada schedule | Prescription |
| ATC code | L01BA04 |
| ATC anatomical main group | L — Antineoplastic and immunomodulating agents |
| ATC therapeutic subgroup | L01BA |
| Current status | MARKETED |
| Status date | 07-May-2021 |
| Original market date | 2021-05-07 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Administered as an intravenous infusion. Patients must receive folic acid and vitamin B12 supplementation and pretreatment with dexamethasone to reduce toxicity.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity to pemetrexed or any ingredient in the formulation; concomitant yellow fever vaccine.
Warnings and precautions
Should be administered under supervision of a physician experienced in cancer chemotherapy. Risk of bone marrow suppression, hepatotoxicity, renal failure, and interstitial pneumonitis.
Is Pemetrexed in shortage in Canada?
A Canadian shortage report is on file for a product containing this molecule: Resolved — reported by EUGIA PHARMA INC., last seen 30 Jul 2026. A shortage on one presentation does not always affect every DIN of the molecule — the alternatives below list what else is marketed in Canada. Nexara can confirm current availability and identify substitutions or import options where permitted.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
14 of 36 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| PEMETREXED DISODIUM FOR INJECTION | 100 MG | POWDER FOR SOLUTION | EUGIA PHARMA INC. | MARKETED | 02528746 |
| PEMETREXED DISODIUM FOR INJECTION | 500 MG | POWDER FOR SOLUTION | ACCORD HEALTHCARE INC | MARKETED | 02438682 |
| PEMETREXED DISODIUM FOR INJECTION | 500 MG | POWDER FOR SOLUTION | AURO PHARMA INC | MARKETED | 02517647 |
| PEMETREXED DISODIUM FOR INJECTION | 100 MG | POWDER FOR SOLUTION | AURO PHARMA INC | MARKETED | 02517639 |
| PEMETREXED DISODIUM FOR INJECTION | 500 MG | POWDER FOR SOLUTION | TEVA CANADA LIMITED | MARKETED | 02394227 |
| PEMETREXED DISODIUM FOR INJECTION | 500 MG | POWDER FOR SOLUTION | EUGIA PHARMA INC. | MARKETED | 02528754 |
| PEMETREXED DISODIUM FOR INJECTION | 100 MG | POWDER FOR SOLUTION | ACCORD HEALTHCARE INC | MARKETED | 02438674 |
| PEMETREXED DISODIUM FOR INJECTION | 100 MG | POWDER FOR SOLUTION | TEVA CANADA LIMITED | MARKETED | 02459434 |
| PEMETREXED FOR INJECTION | 25 MG | SOLUTION | ACCORD HEALTHCARE INC | MARKETED | 02515423 |
| PEMETREXED FOR INJECTION, USP | 500 MG | POWDER FOR SOLUTION | DR REDDY'S LABORATORIES LTD | MARKETED | 02463091 |
2 · Same class — other molecules in ATC L01BA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Methotrexate | ACH-METHOTREXATE · APO-METHOTREXATE · EUGIA-METHOTREXATE · EUGIA-METHOTREXATE TABLETS · +29 more | 51 | 20 | Yes |
| Pemetrexed | ACT PEMETREXED · ALIMTA · PEMETREXED · PEMETREXED DISODIUM FOR INJECTION · +4 more | 36 | 14 | Yes |
| Pralatrexate% | FOLOTYN | 2 | 1 | Yes |
| Raltitrexed | TOMUDEX | 1 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC L01B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| L01BC | Azacitidine · Capecitabine · Cytarabine · Decitabine · Decitabine, Combinations · +4 more | 112 | 34 |
| L01BB | Cladribine · Clofarabine · Fludarabine · Mercaptopurine · Nelarabine · +1 more | 18 | 10 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is TARO-PEMETREXED called?
The same molecule, Pemetrexed, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Pemetrexed Ever Pharma | Latin | Australia, Czechia, Saudi Arabia |
| Alimta | Latin | Bahrain, Morocco, South Africa |
| Pemetrexed Accord | Latin | Australia, Iceland |
| Pexitrex | Latin | Saudi Arabia |
| ARMISARTE | Latin | Czechia |
| Pemetrexed EPC | Latin | Saudi Arabia |
| PEMETREXED EUGIA | Latin | Australia |
| PEMETREXED FRESENIUS KABI | Latin | Czechia |
| PEMETREXED KOANAA | Latin | Bahrain |
| Pemetrexed Seacross | Latin | Saudi Arabia |
| Pemetrexed SUN | Latin | Australia |
| Pemetrexed W&H | Latin | Iceland |
| Pemetrexed-AFT | Latin | Australia |
| Alix | Latin | Saudi Arabia |
| ALMETRA | Latin | Saudi Arabia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.