ADVIL COLD, SINUS & FLU EXTRA STRENGTH 4 MG — DIN 02471604
CHLORPHENIRAMINE MALEATE : 4 MG PSEUDOEPHEDRINE HYDROCHLORIDE : 60 MG IBUPROFEN : 400 MG · HALEON CANADA ULC · TABLET · wholesale supply in Canada
Health Canada status: MARKETED
What is ADVIL COLD, SINUS & FLU EXTRA STRENGTH?
ADVIL COLD, SINUS & FLU EXTRA STRENGTH 4 MG contains CHLORPHENIRAMINE MALEATE : 4 MG PSEUDOEPHEDRINE HYDROCHLORIDE : 60 MG IBUPROFEN : 400 MG. It is listed in the Health Canada Drug Product Database under DIN 02471604, held by HALEON CANADA ULC, supplied as TABLET for ORAL administration. Health Canada currently lists it as marketed, status dated 09-Jul-2026. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is ADVIL COLD, SINUS & FLU EXTRA STRENGTH used for?
Advil Cold & Sinus Nighttime and Advil Cold & Sinus Plus (Ibuprofen, Pseudoephedrine Hydrochloride and Chlorpheniramine Maleate Caplets) is indicated for: the temporary relief of symptoms associated with the common cold, including nasal congestion, sore throat, headache, fever, minor body aches and pains, rhinorrhea, sneezing, itching of the eyes, excessive tearing and sinus pain. Advil Cold, Sinus & Flu Extra Strength (Ibuprofen, Pseudoephedrine Hydrochloride and Chlorpheniramine Maleate Caplets) is indicated for: the temporary relief of combined symptoms associated with the common cold and flu, including nasal congestion, sore throat, headache, fever, minor body aches and pains, rhinorrhea, sneezing, itching of the eyes, excessive tearing and sinus pain. Children’s Advil Cold & Flu Multi-symptom (Ibuprofen, Pseudoephedrine Hydrochloride and Chlorpheniramine Maleate Suspension) is indicated for: the temporary relief of combined symptoms of cold and flu: stuffy nose, fever, minor body aches, sore throat, headache, runny nose, sneezing, itchy, watery eyes and sinus pain.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
Is there a generic Ibuprofen, Combinations in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
9 holders have a Canadian DIN containing Ibuprofen, Combinations, across 40 DINs, of which 13 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| GLAXOSMITHKLINE CONSUMER HEALTHCARE ULC | 11 | 5 | ADVIL COLD & FLU, ADVIL COLD & SINUS CONVENIENCE PACK, ADVIL COLD & SINUS EXTRA STRENGTH LIQUI-GELS, ADVIL COLD & SINUS LIQUI-GELS, ADVIL COLD & SINUS PE, +6 more | Sourceable in Canada |
| HALEON CANADA ULC | 5 | 4 | ADVIL COLD & SINUS PLUS, ADVIL COLD AND SINUS NIGHTTIME, ADVIL COLD, SINUS & FLU EXTRA STRENGTH, ADVIL FLU, CHILDREN'S ADVIL COLD & FLU MULTI-SYMPTOM | Sourceable in Canada |
| VITA HEALTH PRODUCTS INC | 8 | 3 | COLD + SINUS, COLD + SINUS CAPLETS, COLD + SINUS DAYTIME, COLD + SINUS DAYTIME COLD + SINUS NIGHTTIME, COLD + SINUS NIGHTTIME, +3 more | Sourceable in Canada |
| MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC | 5 | 1 | CHILDREN'S MOTRIN COLD, IBUPROFEN AND PSEUDOEPHEDRINE, MOTRIN COLD & SINUS CAPLETS, MOTRIN COLD & SINUS PAIN, SUDAFED SINUS ADVANCE | Sourceable in Canada |
| APOTEX INC | 3 | 0 | COLD & SINUS RELIEF CAPSULES, NIGHTTIME COLD, COUGH & FLU, NIGHTTIME PAIN RELIEF | No marketed DIN |
| MARCAN PHARMACEUTICALS INC | 3 | 0 | COLD AND SINUS PLUS, IBUPROFEN + PSEUDOEPHEDRINE CAPLETS, NIGHTTIME PAIN RELIEVER | No marketed DIN |
| CATALENT ONTARIO LIMITED | 2 | 0 | IBUPROFEN AND DIPHENHYDRAMINE HYDROCHLORIDE CAPSULES, IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE CAPSULES | No marketed DIN |
| WHITEHALL-ROBINS INC. | 2 | 0 | DIMETAPP COLD AND SINUS CAPLETS, DRISTAN SINUS CAPLETS | No marketed DIN |
| PROCTER & GAMBLE INC | 1 | 0 | VICKS DAYQUIL SINUS PR.AND PAIN REL.W.IBUPR. | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 4 MG |
|---|---|
| Dosage form | TABLET |
| Route | ORAL |
| Pack configuration (monograph) | null |
| Storage | null |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Ibuprofen, Combinations |
|---|---|
| ATC code | M01AE51 |
| AHFS class | 04:04.20 ; 28:08.04.92 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02471604 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2471604 |
| Brand name | ADVIL COLD, SINUS & FLU EXTRA STRENGTH |
| Generic / active ingredient | CHLORPHENIRAMINE MALEATE : 4 MG PSEUDOEPHEDRINE HYDROCHLORIDE : 60 MG IBUPROFEN : 400 MG |
| Market authorization holder | HALEON CANADA ULC |
| Health Canada schedule | NON-PRESCRIPTION DRUGS |
| ATC code | M01AE51 |
| ATC anatomical main group | M — Musculo-skeletal system |
| ATC therapeutic subgroup | M01AE |
| Current status | MARKETED |
| Status date | 09-Jul-2026 |
| Original market date | 2018-08-17 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
13 of 40 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| ADVIL COLD & SINUS CONVENIENCE PACK | 2 MG | KIT ; TABLET | GLAXOSMITHKLINE CONSUMER HEALTHCARE ULC | MARKETED | 02399733 |
| ADVIL COLD & SINUS LIQUI-GELS | 200 MG | CAPSULE | GLAXOSMITHKLINE CONSUMER HEALTHCARE ULC | MARKETED | 02250705 |
| ADVIL COLD & SINUS PLUS | 30 MG | TABLET | HALEON CANADA ULC | MARKETED | 02248645 |
| ADVIL COLD AND SINUS | 200 MG | TABLET | GLAXOSMITHKLINE CONSUMER HEALTHCARE ULC | MARKETED | 02036312 |
| ADVIL COLD AND SINUS DAYTIME | 200 MG | TABLET | GLAXOSMITHKLINE CONSUMER HEALTHCARE ULC | MARKETED | 02267616 |
| ADVIL COLD AND SINUS NIGHTTIME | 30 MG | TABLET | HALEON CANADA ULC | MARKETED | 02267632 |
| ADVIL FLU | 200 MG | CAPSULE | HALEON CANADA ULC | MARKETED | 02401193 |
| ADVIL NIGHTTIME | 200 MG | CAPSULE | GLAXOSMITHKLINE CONSUMER HEALTHCARE ULC | MARKETED | 02355841 |
| COLD + SINUS | 200 MG | TABLET | VITA HEALTH PRODUCTS INC | MARKETED | 02352281 |
| COLD + SINUS DAYTIME COLD + SINUS NIGHTTIME | 30 MG | TABLET ; KIT | VITA HEALTH PRODUCTS INC | MARKETED | 02388030 |
2 · Same class — other molecules in ATC M01AE
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Ibuprofen | ACTIPROFEN - CAPLET 200MG · ADVIL 12 HOUR · ADVIL ARTHRITIS PAIN · ADVIL CAPLETS · +107 more | 143 | 46 | Yes |
| Naproxen | ALEVE BACK AND BODY PAIN · ALEVE CAPLETS · ALEVE LIQUID GELS · ALEVE NIGHTTIME · +81 more | 125 | 31 | Yes |
| Ibuprofen, Combinations | ADVIL COLD & FLU · ADVIL COLD & SINUS CONVENIENCE PACK · ADVIL COLD & SINUS EXTRA STRENGTH LIQUI-GELS · ADVIL COLD & SINUS LIQUI-GELS · +36 more | 40 | 13 | Yes |
| Naproxen And Esomeprazole | MYLAN-NAPROXEN/ESOMEPRAZOLE MR · VIMOVO | 4 | 4 | Yes |
| Ketoprofen | KETOPROFEN · KETOPROFEN SR · KETOPROFEN SUPPOSITORIES · KETOPROFEN-E · +28 more | 36 | 3 | Yes |
| Tiaprofenic Acid | ALBERT TIAFEN SR · ALBERT TIAFEN TAB 200MG · ALBERT TIAFEN TAB 300MG · APO-TIAPROFENIC TABLETS -300MG · +15 more | 25 | 2 | Yes |
| Flurbiprofen | ANSAID TABLETS 100 MG · ANSAID TABLETS 50 MG · FLURBIPROFEN · FLURBIPROFEN-100 TAB 100MG · +12 more | 19 | 2 | Yes |
| Oxaprozin | APO-OXAPROZIN · DAYPRO · RHOXAL-OXAPROZIN | 3 | 0 | Not in Canada |
| Fenoprofen | NALFON CAP 300MG · NALFON TAB 600MG | 2 | 0 | Not in Canada |
| Naproxen And Diphenhydramine | PAIN RELIEVER & SLEEP AID | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC M01A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| M01AB | Diclofenac · Diclofenac, Combinations · Etodolac · Indometacin · Ketorolac · +2 more | 170 | 38 |
| M01AH | Celecoxib · Rofecoxib | 72 | 30 |
| M01AC | Meloxicam · Piroxicam · Tenoxicam | 67 | 14 |
| M01AG | Mefenamic Acid | 7 | 1 |
| M01AX | Nabumetone | 12 | 1 |
| M01AA | Oxyphenbutazone · Phenylbutazone · Phenylbutazone, Combinations | 7 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.