ESTRADIOL 0.5 MG — DIN 02451239
ESTRADIOL : 0.5 MG · PHARMASCIENCE INC · TABLET · wholesale supply in Canada
Health Canada status: APPROVED
What is ESTRADIOL?
ESTRADIOL 0.5 MG contains ESTRADIOL : 0.5 MG. It is listed in the Health Canada Drug Product Database under DIN 02451239, held by PHARMASCIENCE INC, supplied as TABLET for ORAL administration. Health Canada currently lists it as approved, status dated 26-Oct-2022. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A). This DIN is not currently being marketed in Canada, so it is sourced to order where a compliant route exists rather than held in stock.
Is there a generic Estradiol in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
15 holders have a Canadian DIN containing Estradiol, across 51 DINs, of which 22 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| SANDOZ CANADA INCORPORATED | 8 | 8 | ESTRADOT 100, ESTRADOT 25, ESTRADOT 37.5, ESTRADOT 50, ESTRADOT 75, +3 more | Sourceable in Canada |
| SEARCHLIGHT PHARMA INC | 8 | 3 | DIVIGEL, OESCLIM | Sourceable in Canada |
| BAYER INC | 4 | 3 | CLIMARA 100, CLIMARA 25, CLIMARA 50, CLIMARA 75 | Sourceable in Canada |
| LUPIN PHARMA CANADA LIMITED | 3 | 3 | LUPIN-ESTRADIOL | Sourceable in Canada |
| KNIGHT THERAPEUTICS INC. | 2 | 2 | IMVEXXY | Sourceable in Canada |
| NOVO NORDISK CANADA INC | 2 | 1 | VAGIFEM, VAGIFEM 10 | Sourceable in Canada |
| ORGANON CANADA INC. | 1 | 1 | ESTROGEL | Sourceable in Canada |
| PFIZER CANADA ULC | 1 | 1 | ESTRING | Sourceable in Canada |
| PHARMASCIENCE INC | 8 | 0 | ESTRADIOL, PMS-ESTRADIOL, PMS-ESTRADIOL 10, PMS-ESTRADIOL VALERATE INJ 10MG/ML | No marketed DIN |
| NOVARTIS PHARMACEUTICALS CANADA INC | 7 | 0 | ESTRADERM-100, ESTRADERM-25, ESTRADERM-50, VIVELLE 100MCG, VIVELLE 37.5MCG, +2 more | No marketed DIN |
| BRISTOL LABS DIVISION OF BRISTOL-MYERS SQUIBB | 2 | 0 | ESTRACE TAB 1MG, ESTRACE TAB 2MG | No marketed DIN |
| FOURNIER PHARMA INC | 2 | 0 | OESCLIM | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 0.5 MG |
|---|---|
| Dosage form | TABLET |
| Route | ORAL |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Estradiol |
|---|---|
| ATC code | G03CA03 |
| AHFS class | 68:16.04 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02451239 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2451239 |
| Brand name | ESTRADIOL |
| Generic / active ingredient | ESTRADIOL : 0.5 MG |
| Market authorization holder | PHARMASCIENCE INC |
| Health Canada schedule | Prescription |
| ATC code | G03CA03 |
| ATC anatomical main group | G — Genito-urinary system and sex hormones |
| ATC therapeutic subgroup | G03CA |
| Current status | APPROVED |
| Status date | 26-Oct-2022 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
22 of 51 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| CLIMARA 25 | 25 MCG / 24 HOUR | PATCH | BAYER INC | MARKETED | 02247499 |
| CLIMARA 50 | 50 MCG / 24 HOUR | PATCH | BAYER INC | MARKETED | 02231509 |
| CLIMARA 75 | 75 MCG / 24 HOUR | PATCH | BAYER INC | MARKETED | 02247500 |
| DIVIGEL | 0.1 % | GEL | SEARCHLIGHT PHARMA INC | MARKETED | 02424924 |
| DIVIGEL | 0.1 % | GEL | SEARCHLIGHT PHARMA INC | MARKETED | 02424835 |
| DIVIGEL | 0.1 % | GEL | SEARCHLIGHT PHARMA INC | MARKETED | 02424843 |
| ESTRADOT 100 | 100 MCG / 24 HOUR | PATCH | SANDOZ CANADA INCORPORATED | MARKETED | 02244002 |
| ESTRADOT 25 | 25 MCG / 24 HOUR | PATCH | SANDOZ CANADA INCORPORATED | MARKETED | 02245676 |
| ESTRADOT 37.5 | 37.5 MCG / 24 HOUR | PATCH | SANDOZ CANADA INCORPORATED | MARKETED | 02243999 |
| ESTRADOT 50 | 50 MCG / 24 HOUR | PATCH | SANDOZ CANADA INCORPORATED | MARKETED | 02244000 |
2 · Same class — other molecules in ATC G03CA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Estradiol | CLIMARA 100 · CLIMARA 25 · CLIMARA 50 · CLIMARA 75 · +31 more | 51 | 22 | Yes |
| Conjugated Estrogens | APO-CONEST TAB 0.3MG · APO-CONEST TAB 0.625MG · APO-CONEST TAB 0.9MG · APO-CONEST TAB 1.25MG · +15 more | 33 | 4 | Yes |
| Estrone | ESTRAGYN VAGINAL CREAM · OESTRILIN CONES VAGINAUX · OESTRILIN CREME VAGINALE 1MG · OGEN .625 · +2 more | 6 | 1 | Yes |
| Ethinylestradiol | ESTINYL TAB 0.05MG · ESTINYL TAB 0.5MG · ESTINYL TABLETS 0.02 MG. | 3 | 0 | Not in Canada |
| Natural And Semisynthetic Estrogens, Plain | ESTRAGYN · NEO ESTRONE TAB 1.25MG | 3 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC G03C
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| G03CC | Conjugated Estrogens And Bazedoxifene | 1 | 1 |
| G03CX | Tibolone | 1 | 1 |
| G03CB | Dienestrol · Diethylstilbestrol | 4 | 0 |
4 · Fixed-dose combinations with Canadian supply
| Product | Active ingredients | Holder | Status | DIN |
|---|---|---|---|---|
| DUAVIVE | CONJUGATED ESTROGENS 0.45 MG; BAZEDOXIFENE (BAZEDOXIFENE ACETATE) 20 MG | PFIZER CANADA ULC | MARKETED | 02432854 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is ESTRADIOL called?
The same molecule, Estradiol, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Estradiol Hexal | Latin | Iceland |
| Estramon | Latin | Iceland |
| Vivelle Dot | Latin | Iceland |
| Estradiol Transdermal System | Latin | Iceland |
| Delestrogen | Latin | Iceland |
| Dermestril | Latin | Iceland |
| Estradiol Valerate | Latin | Iceland |
| Estradot | Latin | Iceland |
| estramon transdermales | Latin | Iceland |
| Estring | Latin | Iceland |
| Estrogel | Latin | Iceland |
| Lenzetto | Latin | Iceland |
| Progynova | Latin | Iceland |
| Rewellfem | Latin | Iceland |
| Vagifem | Latin | Iceland |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
What is Estradiol called in other languages?
Buyers, prescribers and procurement teams outside Canada often search for the ingredient in their own script. These are phonetic renderings of the ingredient name Estradiol, published to help those searches reach this page.
| Language | Estradiol |
|---|---|
| Chinese (Simplified) 简体中文 | 雌二醇 |
| Russian Русский | Эстрадиол |
| Spanish Español | Estradiol |
| French Français | Estradiol |
| Portuguese Português | Estradiol |
| German Deutsch | Estradiol |
| Japanese 日本語 | エストラジオール |
These are transliterations of the ingredient name, generated automatically and published only where two independent checks agreed. They are not registered local trade names and carry no marketing authorisation in any market. Always confirm a product against its local registration before ordering.
How can I get it?
This product is approved by Health Canada but not yet marketed in Canada, so there is no Canadian supply to draw on today. Nexara can tell you whether it has been launched, and can look at supply from other markets where a Canadian pack is not required or where importation is permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.