CLIMARA 50 50 MCG / 24 HOUR — DIN 02231509
ESTRADIOL (ESTRADIOL HEMIHYDRATE) : 50 MCG / 24 HOUR · BAYER INC · PATCH · wholesale supply in Canada
Health Canada status: MARKETED
What is CLIMARA 50?
CLIMARA 50 50 MCG / 24 HOUR contains ESTRADIOL (ESTRADIOL HEMIHYDRATE) : 50 MCG / 24 HOUR. It is listed in the Health Canada Drug Product Database under DIN 02231509, held by BAYER INC, supplied as PATCH for TRANSDERMAL administration. Health Canada currently lists it as marketed, status dated 15-Aug-2008. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
How much does Estradiol cost around the world?
Estradiol is listed on 16 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Belgium publishes a public. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 22 | 158 | USD███.██ |
| Australia | ex-manufacturer | 19 | 34 | AUD███.██ |
| Czechia | max producer price (ex-factory) | 15 | 24 | CZK███.██ |
| Luxembourg | reimbursement | 24 | 24 | EUR███.██ |
| South Africa | single exit price | 22 | 23 | ZAR███.██ |
| Belgium | public | 19 | 19 | EUR███.██ |
| Morocco | PPV (public price) | 8 | 11 | MAD███.██ |
| Austria | KVP (Kassenverkaufspreis) | 8 | 9 | EUR███.██ |
| Sweden | AIP (pharmacy purchase price) | 3 | 8 | SEK███.██ |
| Saudi Arabia | public | 7 | 7 | SAR███.██ |
| Greece | producer price (ex-factory) | 5 | 5 | EUR███.██ |
| Spain | PVP con IVA (public price) | 4 | 4 | EUR███.██ |
| Brazil | preco fabrica (ex-factory ceiling) | 1 | 3 | BRL███.██ |
| Romania | max producer price | 2 | 2 | RON███.██ |
| United Kingdom | hospital | 1 | 1 | GBP███.██ |
| Slovakia | categorised final price | 1 | 1 | EUR███.██ |
333 pack listings across 161 brand entries and 15 price bases, refreshed 08 Sep 2026. Ranges span every Estradiol pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Estradiol in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
15 holders have a Canadian DIN containing Estradiol, across 51 DINs, of which 22 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| SANDOZ CANADA INCORPORATED | 8 | 8 | ESTRADOT 100, ESTRADOT 25, ESTRADOT 37.5, ESTRADOT 50, ESTRADOT 75, +3 more | Sourceable in Canada |
| SEARCHLIGHT PHARMA INC | 8 | 3 | DIVIGEL, OESCLIM | Sourceable in Canada |
| BAYER INC | 4 | 3 | CLIMARA 100, CLIMARA 25, CLIMARA 50, CLIMARA 75 | Sourceable in Canada |
| LUPIN PHARMA CANADA LIMITED | 3 | 3 | LUPIN-ESTRADIOL | Sourceable in Canada |
| KNIGHT THERAPEUTICS INC. | 2 | 2 | IMVEXXY | Sourceable in Canada |
| NOVO NORDISK CANADA INC | 2 | 1 | VAGIFEM, VAGIFEM 10 | Sourceable in Canada |
| ORGANON CANADA INC. | 1 | 1 | ESTROGEL | Sourceable in Canada |
| PFIZER CANADA ULC | 1 | 1 | ESTRING | Sourceable in Canada |
| PHARMASCIENCE INC | 8 | 0 | ESTRADIOL, PMS-ESTRADIOL, PMS-ESTRADIOL 10, PMS-ESTRADIOL VALERATE INJ 10MG/ML | No marketed DIN |
| NOVARTIS PHARMACEUTICALS CANADA INC | 7 | 0 | ESTRADERM-100, ESTRADERM-25, ESTRADERM-50, VIVELLE 100MCG, VIVELLE 37.5MCG, +2 more | No marketed DIN |
| BRISTOL LABS DIVISION OF BRISTOL-MYERS SQUIBB | 2 | 0 | ESTRACE TAB 1MG, ESTRACE TAB 2MG | No marketed DIN |
| FOURNIER PHARMA INC | 2 | 0 | OESCLIM | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 50 MCG / 24 HOUR |
|---|---|
| Dosage form | PATCH |
| Route | TRANSDERMAL |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation, because this listing covers more than one of them.
Substance and classification
| Active substance | Estradiol |
|---|---|
| ATC code | G03CA03 |
| AHFS class | 68:16.04 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02231509 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2231509 |
| Brand name | CLIMARA 50 |
| Generic / active ingredient | ESTRADIOL (ESTRADIOL HEMIHYDRATE) : 50 MCG / 24 HOUR |
| Market authorization holder | BAYER INC |
| Health Canada schedule | Prescription |
| ATC code | G03CA03 |
| ATC anatomical main group | G — Genito-urinary system and sex hormones |
| ATC therapeutic subgroup | G03CA |
| Current status | MARKETED |
| Status date | 15-Aug-2008 |
| Original market date | 1997-12-01 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
22 of 51 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| CLIMARA 25 | 25 MCG / 24 HOUR | PATCH | BAYER INC | MARKETED | 02247499 |
| CLIMARA 75 | 75 MCG / 24 HOUR | PATCH | BAYER INC | MARKETED | 02247500 |
| DIVIGEL | 0.1 % | GEL | SEARCHLIGHT PHARMA INC | MARKETED | 02424835 |
| DIVIGEL | 0.1 % | GEL | SEARCHLIGHT PHARMA INC | MARKETED | 02424843 |
| DIVIGEL | 0.1 % | GEL | SEARCHLIGHT PHARMA INC | MARKETED | 02424924 |
| ESTRADOT 100 | 100 MCG / 24 HOUR | PATCH | SANDOZ CANADA INCORPORATED | MARKETED | 02244002 |
| ESTRADOT 25 | 25 MCG / 24 HOUR | PATCH | SANDOZ CANADA INCORPORATED | MARKETED | 02245676 |
| ESTRADOT 37.5 | 37.5 MCG / 24 HOUR | PATCH | SANDOZ CANADA INCORPORATED | MARKETED | 02243999 |
| ESTRADOT 50 | 50 MCG / 24 HOUR | PATCH | SANDOZ CANADA INCORPORATED | MARKETED | 02244000 |
| ESTRADOT 75 | 75 MCG / 24 HOUR | PATCH | SANDOZ CANADA INCORPORATED | MARKETED | 02244001 |
2 · Same class — other molecules in ATC G03CA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Estradiol | CLIMARA 100 · CLIMARA 25 · CLIMARA 50 · CLIMARA 75 · +31 more | 51 | 22 | Yes |
| Conjugated Estrogens | APO-CONEST TAB 0.3MG · APO-CONEST TAB 0.625MG · APO-CONEST TAB 0.9MG · APO-CONEST TAB 1.25MG · +15 more | 33 | 4 | Yes |
| Estrone | ESTRAGYN VAGINAL CREAM · OESTRILIN CONES VAGINAUX · OESTRILIN CREME VAGINALE 1MG · OGEN .625 · +2 more | 6 | 1 | Yes |
| Ethinylestradiol | ESTINYL TAB 0.05MG · ESTINYL TAB 0.5MG · ESTINYL TABLETS 0.02 MG. | 3 | 0 | Not in Canada |
| Natural And Semisynthetic Estrogens, Plain | ESTRAGYN · NEO ESTRONE TAB 1.25MG | 3 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC G03C
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| G03CC | Conjugated Estrogens And Bazedoxifene | 1 | 1 |
| G03CX | Tibolone | 1 | 1 |
| G03CB | Dienestrol · Diethylstilbestrol | 4 | 0 |
4 · Fixed-dose combinations with Canadian supply
| Product | Active ingredients | Holder | Status | DIN |
|---|---|---|---|---|
| DUAVIVE | CONJUGATED ESTROGENS 0.45 MG; BAZEDOXIFENE (BAZEDOXIFENE ACETATE) 20 MG | PFIZER CANADA ULC | MARKETED | 02432854 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is CLIMARA 50 called?
The same molecule, Estradiol, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Sandrena | Latin | Australia, Brazil |
| Cliovelle | Latin | Sweden |
| Estramon (Germany, Sandoz) | Latin | Australia |
| FEMOSTON | Latin | Czechia |
| Progynova | Latin | Australia |
| ESTROFEM | Latin | Czechia, Morocco |
| FEMOSTON MINI | Latin | Czechia |
| Noresmea | Latin | Czechia, Sweden |
| ACTIVELLE | Latin | Czechia |
| Activelle® | Latin | Sweden |
| Estalis | Latin | South Africa |
| ESTRADERM | Latin | Morocco |
| ESTRAHEXAL | Latin | Czechia |
| ESTREVA | Latin | Morocco |
| Estro-Pess | Latin | Australia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.