IMIPENEM AND CILASTATIN FOR INJECTION, USP 250 MG — DIN 02439840
CILASTATIN (CILASTATIN SODIUM) : 250 MG IMIPENEM : 250 MG · METHAPHARM INC · POWDER FOR SOLUTION · wholesale supply in Canada
Health Canada status: CANCELLED PRE MARKET
What is IMIPENEM AND CILASTATIN FOR INJECTION, USP?
IMIPENEM AND CILASTATIN FOR INJECTION, USP 250 MG contains CILASTATIN (CILASTATIN SODIUM) : 250 MG IMIPENEM : 250 MG. It is listed in the Health Canada Drug Product Database under DIN 02439840, held by METHAPHARM INC, supplied as POWDER FOR SOLUTION for INTRAVENOUS administration. Health Canada currently lists it as cancelled pre market, status dated 23-Apr-2018. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
How much does Imipenem And Cilastatin cost around the world?
Imipenem And Cilastatin is listed on 6 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Bahrain publishes a retail (max); Czechia publishes a max producer price (ex-factory); Romania publishes a max producer price. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Romania | max producer price | 5 | 9 | RON███.██ |
| South Africa | single exit price | 8 | 9 | ZAR███.██ |
| Czechia | max producer price (ex-factory) | 3 | 4 | CZK███.██ |
| Bahrain | retail (max) | 2 | 2 | BHD███.██ |
| Saudi Arabia | public | 2 | 2 | SAR███.██ |
| United Kingdom | hospital | 1 | 1 | GBP███.██ |
27 pack listings across 21 brand entries and 6 price bases, refreshed 03 Sep 2026. Ranges span every Imipenem And Cilastatin pack in that market, so a high figure is usually a larger pack rather than the same product.
This table is a regulatory record of where the molecule is listed. The DIN on this page is no longer authorized for sale in Canada, so Nexara does not quote it — see the alternatives above.
Is there a generic Imipenem And Cilastatin in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
7 holders have a Canadian DIN containing Imipenem And Cilastatin, across 14 DINs, of which 2 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| SANDOZ CANADA INCORPORATED | 2 | 1 | IMIPENEM AND CILASTATIN FOR INJECTION USP | Sourceable in Canada |
| SUN PHARMA CANADA INC | 2 | 1 | TARO-IMIPENEM-CILASTATIN | Sourceable in Canada |
| MERCK CANADA INC | 3 | 0 | PRIMAXIN 250, PRIMAXIN 500, PRIMAXIN IV 500 | No marketed DIN |
| METHAPHARM INC | 2 | 0 | IMIPENEM AND CILASTATIN FOR INJECTION, USP | No marketed DIN |
| PFIZER CANADA ULC | 2 | 0 | IMIPENEM AND CILASTATIN FOR INJECTION | No marketed DIN |
| STERIMAX INC | 2 | 0 | IMIPENEM AND CILASTATIN FOR INJECTION, USP | No marketed DIN |
| MERCK FROSST CANADA & CIE, MERCK FROSST CANADA & CO. | 1 | 0 | PRIMAXIN IV 250/250 ADD-VANTAGE VIAL | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 250 MG |
|---|---|
| Dosage form | POWDER FOR SOLUTION |
| Route | INTRAVENOUS |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Imipenem And Cilastatin |
|---|---|
| ATC code | J01DH51 |
| AHFS class | 08:12.07.08 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02439840 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2439840 |
| Brand name | IMIPENEM AND CILASTATIN FOR INJECTION, USP |
| Generic / active ingredient | CILASTATIN (CILASTATIN SODIUM) : 250 MG IMIPENEM : 250 MG |
| Market authorization holder | METHAPHARM INC |
| Health Canada schedule | Prescription |
| ATC code | J01DH51 |
| ATC anatomical main group | J — Anti-infectives for systemic use |
| ATC therapeutic subgroup | J01DH |
| Current status | CANCELLED PRE MARKET |
| Status date | 23-Apr-2018 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
2 of 14 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| IMIPENEM AND CILASTATIN FOR INJECTION USP | 500 MG | POWDER FOR SOLUTION | SANDOZ CANADA INCORPORATED | MARKETED | 02358344 |
| TARO-IMIPENEM-CILASTATIN | 500 MG | POWDER FOR SOLUTION | SUN PHARMA CANADA INC | MARKETED | 02351706 |
| IMIPENEM AND CILASTATIN FOR INJECTION | 500 MG | POWDER FOR SOLUTION | PFIZER CANADA ULC | CANCELLED POST MARKET | 02357437 |
| IMIPENEM AND CILASTATIN FOR INJECTION | 250 MG | POWDER FOR SOLUTION | PFIZER CANADA ULC | CANCELLED PRE MARKET | 02357429 |
| IMIPENEM AND CILASTATIN FOR INJECTION USP | 250 MG | POWDER FOR SOLUTION | SANDOZ CANADA INCORPORATED | CANCELLED POST MARKET | 02358336 |
| IMIPENEM AND CILASTATIN FOR INJECTION, USP | 500 MG | POWDER FOR SOLUTION | STERIMAX INC | APPROVED | 02441233 |
| IMIPENEM AND CILASTATIN FOR INJECTION, USP | 500 MG | POWDER FOR SOLUTION | METHAPHARM INC | CANCELLED PRE MARKET | 02439859 |
| IMIPENEM AND CILASTATIN FOR INJECTION, USP | 250 MG | POWDER FOR SOLUTION | STERIMAX INC | APPROVED | 02441225 |
| PRIMAXIN 250 | 250 MG | POWDER FOR SOLUTION | MERCK CANADA INC | CANCELLED POST MARKET | 00717274 |
| PRIMAXIN 500 | 500 MG | POWDER FOR SOLUTION | MERCK CANADA INC | CANCELLED POST MARKET | 00717282 |
2 · Same class — other molecules in ATC J01DH
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Meropenem | MEROPENEM FOR INJECTION · MEROPENEM FOR INJECTION SDZ · MEROPENEM FOR INJECTION USP · MEROPENEM FOR INJECTION USP AND SODIUM CHLORIDE INJECTION USP · +3 more | 26 | 15 | Yes |
| Ertapenem | ERTAPENEM FOR INJECTION · INVANZ | 9 | 6 | Yes |
| Imipenem And Cilastatin | IMIPENEM AND CILASTATIN FOR INJECTION · IMIPENEM AND CILASTATIN FOR INJECTION USP · IMIPENEM AND CILASTATIN FOR INJECTION, USP · PRIMAXIN 250 · +4 more | 14 | 2 | Yes |
| Meropenem And Vaborbactam | VABOMERE | 1 | 1 | Yes |
| Doripenem | DORIBAX | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC J01D
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| J01DB | Cefadroxil · Cefalexin · Cefalotin · Cefazolin | 91 | 41 |
| J01DD | Cefixime · Cefotaxime · Cefpodoxime · Ceftazidime · Ceftizoxime · +1 more | 96 | 25 |
| J01DC | Cefaclor · Cefamandole · Cefotetan · Cefoxitin · Cefprozil · +1 more | 135 | 18 |
| J01DE | Cefepime | 10 | 3 |
| J01DF | Aztreonam | 1 | 1 |
| J01DI | Ceftobiprole Medocaril · Ceftolozane And Beta-Lactamase Inhibitor | 2 | 1 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is IMIPENEM AND CILASTATIN FOR INJECTION, USP called?
The same molecule, Imipenem And Cilastatin, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| IMIPENEM/CILASTATIN KABI | Latin | Czechia |
| CILNEM | Latin | South Africa |
| ENAROS | Latin | Czechia |
| IMIPENEM/CILASTATIN APTAPHARMA | Latin | Czechia |
| LASTINEM | Latin | Bahrain |
| PREMAX | Latin | Bahrain |
| Recarbrio | Latin | Saudi Arabia |
| TIASEP | Latin | South Africa |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled pre market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.