SPIRIVA RESPIMAT 2.5 MCG — DIN 02435381
TIOTROPIUM (TIOTROPIUM BROMIDE MONOHYDRATE) : 2.5 MCG · BOEHRINGER INGELHEIM (CANADA) LTD LTEE · SOLUTION · wholesale supply in Canada
Health Canada status: MARKETED
What is SPIRIVA RESPIMAT?
SPIRIVA RESPIMAT 2.5 MCG contains TIOTROPIUM (TIOTROPIUM BROMIDE MONOHYDRATE) : 2.5 MCG. It is listed in the Health Canada Drug Product Database under DIN 02435381, held by BOEHRINGER INGELHEIM (CANADA) LTD LTEE, supplied as SOLUTION for INHALATION administration. Health Canada currently lists it as marketed, status dated 19-Dec-2014. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is SPIRIVA RESPIMAT used for?
Maintenance bronchodilator for COPD (including chronic bronchitis/emphysema) and reduction of exacerbations. Add-on maintenance for adults with asthma symptomatic on ICS/LABA with past exacerbations.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Tiotropium Bromide cost around the world?
Tiotropium Bromide is listed on 11 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Belgium publishes a public. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Australia | ex-manufacturer | 5 | 14 | AUD███.██ |
| Sweden | AIP (pharmacy purchase price) | 4 | 12 | SEK███.██ |
| Greece | producer price (ex-factory) | 7 | 7 | EUR███.██ |
| Saudi Arabia | public | 7 | 7 | SAR███.██ |
| Czechia | max producer price (ex-factory) | 2 | 6 | CZK███.██ |
| Austria | KVP (Kassenverkaufspreis) | 5 | 5 | EUR███.██ |
| Luxembourg | reimbursement | 5 | 5 | EUR███.██ |
| Romania | max producer price | 4 | 5 | RON███.██ |
| Belgium | public | 4 | 4 | EUR███.██ |
| Morocco | PPV (public price) | 2 | 4 | MAD███.██ |
| South Africa | single exit price | 1 | 1 | ZAR███.██ |
70 pack listings across 46 brand entries and 10 price bases, refreshed 08 Sep 2026. Ranges span every Tiotropium Bromide pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Tiotropium Bromide in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
3 holders have a Canadian DIN containing Tiotropium Bromide, across 4 DINs, of which 4 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| BOEHRINGER INGELHEIM (CANADA) LTD LTEE | 2 | 2 | SPIRIVA, SPIRIVA RESPIMAT | Sourceable in Canada |
| APOTEX INC | 1 | 1 | APO-TIOTROPIUM | Sourceable in Canada |
| LUPIN PHARMA CANADA LIMITED | 1 | 1 | LUPIN-TIOTROPIUM | Sourceable in Canada |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 2.5 MCG |
|---|---|
| Dosage form | SOLUTION |
| Route | INHALATION |
| Pack configuration (monograph) | SPIRIVA RESPIMAT cartridge for use only with the SPIRIVA RESPIMAT Inhaler. |
| Storage | Not explicitly detailed in provided text summary (Table of Contents lists page 18, but text ends at page 14). Standard practice is 15-30°C. |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Tiotropium Bromide |
|---|---|
| ATC code | R03BB04 |
| AHFS class | 12:08.08 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02435381 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2435381 |
| Brand name | SPIRIVA RESPIMAT |
| Generic / active ingredient | TIOTROPIUM (TIOTROPIUM BROMIDE MONOHYDRATE) : 2.5 MCG |
| Market authorization holder | BOEHRINGER INGELHEIM (CANADA) LTD LTEE |
| Health Canada schedule | Prescription |
| ATC code | R03BB04 |
| ATC anatomical main group | R — Respiratory system |
| ATC therapeutic subgroup | R03BB |
| Current status | MARKETED |
| Status date | 19-Dec-2014 |
| Original market date | 2014-12-19 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
2 inhalations of 2.5 mcg once daily at the same time of day. Administered via inhalation only through the RESPIMAT device. Do not exceed one dose every 24 hours.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
History of hypersensitivity to tiotropium bromide, atropine or its derivatives (e.g., ipratropium), or to any component of this product.
Warnings and precautions
Not for acute use/rescue. Risk of paradoxical bronchospasm, worsening of narrow-angle glaucoma, and urinary retention. Immediate hypersensitivity reactions may occur.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
4 of 4 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| APO-TIOTROPIUM | 18 MCG | CAPSULE | APOTEX INC | MARKETED | 02550865 |
| LUPIN-TIOTROPIUM | 18 MCG | CAPSULE | LUPIN PHARMA CANADA LIMITED | MARKETED | 02537850 |
| SPIRIVA | 18 MCG | CAPSULE | BOEHRINGER INGELHEIM (CANADA) LTD LTEE | MARKETED | 02246793 |
2 · Same class — other molecules in ATC R03BB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Ipratropium Bromide | AA-IPRAVENT · APO-IPRAVENT STERULES · ATROVENT · ATROVENT HFA · +20 more | 30 | 8 | Yes |
| Tiotropium Bromide | APO-TIOTROPIUM · LUPIN-TIOTROPIUM · SPIRIVA · SPIRIVA RESPIMAT | 4 | 4 | Yes |
| Aclidinium Bromide | TUDORZA GENUAIR | 1 | 1 | Yes |
| Glycopyrronium Bromide | SEEBRI BREEZHALER | 1 | 1 | Yes |
| Umeclidinium Bromide | INCRUSE ELLIPTA | 1 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC R03B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| R03BA | Beclometasone · Budesonide · Ciclesonide · Flunisolide · Fluticasone · +3 more | 66 | 33 |
| R03BC | Cromoglicic Acid · Nedocromil | 11 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is SPIRIVA RESPIMAT called?
The same molecule, Tiotropium Bromide, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Spiriva | Latin | Australia, Czechia, Morocco |
| Tiogiva | Latin | Saudi Arabia, Sweden |
| Spiolto Respimat | Latin | Australia, Saudi Arabia |
| Spiriva® | Latin | Sweden |
| Tiotropium STADA | Latin | Sweden |
| Braltus | Latin | Australia |
| Tiotropium Lupin | Latin | Australia |
| Tiotropium PharmaS | Latin | Sweden |
| SPIOLTO RESPIMATE | Latin | Saudi Arabia |
| Tiomist | Latin | Saudi Arabia |
| Tiotropium Eva | Latin | Saudi Arabia |
| Triova | Latin | Saudi Arabia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.