APO-QUINAPRIL/HCTZ 10 MG
QUINAPRIL (QUINAPRIL HYDROCHLORIDE) : 10 MG HYDROCHLOROTHIAZIDE : 12.5 MG · DIN 02408767 · APOTEX INC
Health Canada status: MARKETED
What is APO-QUINAPRIL/HCTZ?
APO-QUINAPRIL/HCTZ 10 MG contains QUINAPRIL (QUINAPRIL HYDROCHLORIDE) : 10 MG HYDROCHLOROTHIAZIDE : 12.5 MG. It is listed in the Health Canada Drug Product Database under DIN 02408767, held by APOTEX INC, supplied as TABLET for ORAL administration. Health Canada currently lists it as marketed, status dated 16-Jun-2025. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is APO-QUINAPRIL/HCTZ used for?
Treatment of essential hypertension in patients for whom combination therapy is appropriate. Not indicated for initial therapy.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
Product details and regulatory record
| DIN | 02408767 |
|---|---|
| Brand name | APO-QUINAPRIL/HCTZ |
| Generic / active ingredient | QUINAPRIL (QUINAPRIL HYDROCHLORIDE) : 10 MG HYDROCHLOROTHIAZIDE : 12.5 MG |
| Manufacturer | APOTEX INC |
| Strength | 10 MG |
| Dosage form | TABLET |
| Route of administration | ORAL |
| Schedule | Prescription |
| ATC code | C09BA06 QUINAPRIL AND DIURETICS |
| AHFS class | 24:32.04 ; 40:28.20 |
| Biosimilar | No |
| Health Canada status | MARKETED |
| Status date | 16-Jun-2025 |
| Original market date | 2013-08-13 00:00:00 |
How is it administered?
Individualize dosage by titration of components. Not for initial therapy. Once titrated, the fixed combination may be substituted. Usual quinapril dose 10-20 mg/day; HCTZ usually not >50 mg/day.
Included because it drives pack selection and wastage. Consult the monograph.
How is it stored and handled?
Not explicitly detailed in provided text (Section 11 mentioned in TOC but text cuts off). Standard practice is 15-30°C.
How is it supplied?
Blister Pack of 28 (2 X 14) tablets and HDPE bottles of 90 tablets.
Contraindications
Hypersensitivity to quinapril, HCTZ, or sulfonamides; history of ACEI-related angioedema; use with sacubitril/valsartan; anuria; pregnancy; nursing; use with aliskiren or ARBs in specific patients.
Warnings and precautions
Fetal toxicity; angioedema (can be fatal); hypotension; non-melanoma skin cancer risk; electrolyte imbalances (hyper/hypokalemia); neutropenia/agranulocytosis; hepatic impairment risks.
What can be used instead?
Other Canadian products sharing ATC code C09BA06 QUINAPRIL AND DIURETICS. 8 of 20 DINs in this group are currently marketed — marketed products are listed first, because that is what can actually be bought. These tables describe supply, not clinical equivalence: substitution rests with the prescriber or pharmacist, and interchangeability is determined provincially.
| Product | Strength | Form | Manufacturer | Health Canada status | DIN |
|---|---|---|---|---|---|
| APO-QUINAPRIL/HCTZ | 12.5 MG | TABLET | APOTEX INC | MARKETED | DIN 02408775 |
| APO-QUINAPRIL/HCTZ | 20 MG | TABLET | APOTEX INC | MARKETED | DIN 02408783 |
| AURO-QUINAPRIL HCTZ | 12.5 MG | TABLET | AURO PHARMA INC | MARKETED | DIN 02473305 |
| AURO-QUINAPRIL HCTZ | 12.5 MG | TABLET | AURO PHARMA INC | MARKETED | DIN 02473291 |
| AURO-QUINAPRIL HCTZ | 25 MG | TABLET | AURO PHARMA INC | MARKETED | DIN 02473321 |
| JAMP QUINAPRIL / HCTZ | 12.5 MG | TABLET | JAMP PHARMA CORPORATION | MARKETED | DIN 02547430 |
| JAMP QUINAPRIL / HCTZ | 20 MG | TABLET | JAMP PHARMA CORPORATION | MARKETED | DIN 02547449 |
| ACCURETIC | 10 MG | TABLET | PFIZER CANADA ULC | CANCELLED POST MARKET | DIN 02237367 |
| ACCURETIC | 20 MG | TABLET | PFIZER CANADA ULC | CANCELLED POST MARKET | DIN 02237368 |
| ACCURETIC | 25 MG | TABLET | PFIZER CANADA ULC | CANCELLED POST MARKET | DIN 02237369 |
Who else supplies QUINAPRIL AND DIURETICS worldwide?
Nexara tracks national medicine registries and published price lists across multiple markets. QUINAPRIL AND DIURETICS appears in 23 registered pack listings across 5 markets, published on 4 different national price bases. Where a Canadian route is closed, that is where an alternative route of supply starts — subject to the import rules in both countries.
Registered listings are not stock. Ask us to confirm what can actually be sourced for your order.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.