APO-TRIMIPRAMINE 100 MG — DIN 02405393
TRIMIPRAMINE (TRIMIPRAMINE MALEATE) : 100 MG · APOTEX INC · TABLET · wholesale supply in Canada
Health Canada status: APPROVED
What is APO-TRIMIPRAMINE?
APO-TRIMIPRAMINE 100 MG contains TRIMIPRAMINE (TRIMIPRAMINE MALEATE) : 100 MG. It is listed in the Health Canada Drug Product Database under DIN 02405393, held by APOTEX INC, supplied as TABLET for ORAL administration. Health Canada currently lists it as approved, status dated 01-May-2013. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A). This DIN is not currently being marketed in Canada, so it is sourced to order where a compliant route exists rather than held in stock.
What is APO-TRIMIPRAMINE used for?
Indicated in the drug treatment of depressive illness. It is effective in endogenous depression.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Trimipramine cost around the world?
Trimipramine is listed on 3 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Morocco publishes a PPV (public price); South Africa publishes a single exit price; United Kingdom publishes a hospital. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Morocco | PPV (public price) | 1 | 4 | MAD███.██ |
| South Africa | single exit price | 2 | 3 | ZAR███.██ |
| United Kingdom | hospital | 1 | 1 | GBP███.██ |
8 pack listings across 4 brand entries and 3 price bases, refreshed 05 Sep 2026. Ranges span every Trimipramine pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Trimipramine in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
7 holders have a Canadian DIN containing Trimipramine, across 32 DINs, of which 5 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| AA PHARMA INC | 5 | 5 | TRIMIPRAMINE | Sourceable in Canada |
| SANOFI-AVENTIS CANADA INC | 7 | 0 | RHOTRIMINE, SURMONTIL | No marketed DIN |
| APOTEX INC | 5 | 0 | APO-TRIMIPRAMINE | No marketed DIN |
| PRO DOC LIMITEE | 5 | 0 | TRIMIPRAMINE TAB 100MG, TRIMIPRAMINE TAB 12.5MG, TRIMIPRAMINE TAB 25MG, TRIMIPRAMINE TAB 50MG, TRIMIPRAMINE-75 - CAP 75MG | No marketed DIN |
| NU-PHARM INC | 4 | 0 | NU-TRIMIPRAMINE TAB 100MG, NU-TRIMIPRAMINE TAB 12.5MG, NU-TRIMIPRAMINE TAB 25MG, NU-TRIMIPRAMINE TAB 50MG | No marketed DIN |
| AVENTIS PHARMA INC | 3 | 0 | SURMONTIL 100, SURMONTIL 12.5, SURMONTIL 75 | No marketed DIN |
| NOVOPHARM LIMITED | 3 | 0 | NOVO-TRIPRAMINE TAB 100MG BP, NOVO-TRIPRAMINE TAB 25MG BP, NOVO-TRIPRAMINE TAB 50MG BP | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 100 MG |
|---|---|
| Dosage form | TABLET |
| Route | ORAL |
| Pack configuration (monograph) | Bottles of 100, 500 and 1000 tablets or capsules. |
| Storage | Protect from light. Store at controlled room temperature 15-30°C (59-86°F). |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Trimipramine |
|---|---|
| ATC code | N06AA06 |
| AHFS class | 28:16.04.28 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02405393 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2405393 |
| Brand name | APO-TRIMIPRAMINE |
| Generic / active ingredient | TRIMIPRAMINE (TRIMIPRAMINE MALEATE) : 100 MG |
| Market authorization holder | APOTEX INC |
| Health Canada schedule | Prescription |
| ATC code | N06AA06 |
| ATC anatomical main group | N — Nervous system |
| ATC therapeutic subgroup | N06AA |
| Current status | APPROVED |
| Status date | 01-May-2013 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Adults: Initially 75 mg/day in divided doses, usual optimal 150-200 mg/day (max 300 mg). Elderly: Start 12.5-50 mg/day, increase by 25 mg/week to 50-150 mg/day. Bedtime single dosing possible.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity; concomitant MAOIs (within 2 weeks); narrow angle glaucoma; prostatic hypertrophy; acute recovery phase post-myocardial infarction; acute congestive heart failure.
Warnings and precautions
Risk of arrhythmias, tachycardia, MI, stroke, and sudden death. Caution in cardiovascular disease, hyperthyroidism, and seizure disorders. May impair driving/mental alertness.
Is Trimipramine in shortage in Canada?
A Canadian shortage report is on file for a product containing this molecule: Resolved — reported by AA PHARMA INC, last seen 13 Apr 2026. A shortage on one presentation does not always affect every DIN of the molecule — the alternatives below list what else is marketed in Canada. Nexara can confirm current availability and identify substitutions or import options where permitted.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
5 of 32 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| TRIMIPRAMINE | 100 MG | TABLET | AA PHARMA INC | MARKETED | 00740829 |
| TRIMIPRAMINE | 75 MG | CAPSULE | AA PHARMA INC | MARKETED | 02070987 |
| TRIMIPRAMINE | 25 MG | TABLET | AA PHARMA INC | MARKETED | 00740802 |
| TRIMIPRAMINE | 12.5 MG | TABLET | AA PHARMA INC | MARKETED | 00740799 |
| TRIMIPRAMINE | 50 MG | TABLET | AA PHARMA INC | MARKETED | 00740810 |
| APO-TRIMIPRAMINE | 12.5 MG | TABLET | APOTEX INC | APPROVED | 02405369 |
| APO-TRIMIPRAMINE | 50 MG | TABLET | APOTEX INC | APPROVED | 02405385 |
| APO-TRIMIPRAMINE | 25 MG | TABLET | APOTEX INC | APPROVED | 02405377 |
| APO-TRIMIPRAMINE | 75 MG | CAPSULE | APOTEX INC | APPROVED | 02405407 |
| NOVO-TRIPRAMINE TAB 100MG BP | 100 MG | TABLET | NOVOPHARM LIMITED | CANCELLED POST MARKET | 01940457 |
2 · Same class — other molecules in ATC N06AA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Doxepin | ALTI-DOXEPIN - CAP 10MG · ALTI-DOXEPIN-CAP 25MG · ALTI-DOXEPIN-CAP 50MG · ALTI-DOXEPIN-CAP 75MG · APO-DOXEPIN · DOXEPINE-10 - CAP · DOXEPINE-100 - CAP · DOXEPINE-150 - CAP · DOXEPINE-25 -CAP · DOXEPINE-50 - CAP · DOXEPINE-75 - CAP · JAMP DOXEPIN · MAR-DOXEPIN · NOVO-DOXEPIN · NTP-DOXEPIN · RHO-DOXEPIN - CAP 25MG · RHO-DOXEPIN - CAP 50MG · RHO-DOXEPIN-10 MG CAP · SILENOR · SINEQUAN · SINEQUAN CAP 150MG · TRIADAPIN CAP 100MG · TRIADAPIN CAP 10MG · TRIADAPIN CAP 25MG · TRIADAPIN CAP 50MG · TRIADAPIN CAP 75MG | 51 | 22 | Yes |
| Amitriptyline | AG-AMITRIPTYLINE · AMITRIPTYLINE · AMITRIPTYLINE 10 TAB · AMITRIPTYLINE 25 TAB · AMITRIPTYLINE HCL TAB 25MG · AMITRIPTYLINE HCL TAB 50MG · AMITRIPTYLINE HYDROCHLORIDE TABLETS USP · AMITRIPTYLINE TABLETS B.P 25MG · AMITRIPTYLINE-10 · AMITRIPTYLINE-25 · AMITRIPTYLINE-50 · APO-AMITRIPTYLINE · BIO-AMITRIPTYLINE · DOM-AMITRIPTYLINE · ELAVIL · ELAVIL PAMOATE SYR 10MG/5ML · ELAVIL TABLET 10MG · ELAVIL TABLET 25MG · ELAVIL TABLET 50MG · ELAVIL TABLET 75MG · IPG-AMITRIPTYLINE · JAMP-AMITRIPTYLINE · JAMP-AMITRIPTYLINE TABLETS · LEVATE · MAR-AMITRIPTYLINE · NOVO-TRIPTYN TAB 10MG · NOVO-TRIPTYN TAB 25MG · NOVO-TRIPTYN TAB 50MG · NU-AMITRIPTYLINE TABLETS · PMS-AMITRIPTYLINE · PRIVA-AMITRIPTYLINE · TEVA-AMITRIPTYLINE | 83 | 15 | Yes |
| Imipramine | APO-IMIPRAMINE · APO-IMIPRAMINE TABLETS · IMIPRAMINE 10TAB · IMIPRAMINE 25TAB · IMIPRAMINE 50 TAB 50MG · IMIPRAMINE HYDROCHLORIDE TABLETS 25MG · IMIPRAMINE HYDROCHLORIDE TABLETS 50MG · IMIPRAMINE TAB 25MG · IMPRIL · JAMP IMIPRAMINE · NOVO-PRAMINE TAB 10MG · NOVO-PRAMINE TAB 25MG · NOVO-PRAMINE TAB 50MG · PMS IMIPRAMINE TAB 10MG · PMS IMIPRAMINE TAB 25MG · PMS IMIPRAMINE TAB 50MG · TOFRANIL 10MG · TOFRANIL 25MG · TOFRANIL 50MG · TOFRANIL 75MG | 32 | 8 | Yes |
| Desipramine | DESIPRAMINE · DESIPRAMINE-10 - TAB 10MG · DESIPRAMINE-25 - TAB 25MG · DESIPRAMINE-50 - TAB 50MG · DESIPRAMINE-75 - TAB 75MG · DOM-DESIPRAMINE TABLETS - 25MG · DOM-DESIPRAMINE TABLETS - 50MG · NORPRAMIN 100MG TAB · NORPRAMIN 10MG TAB · NORPRAMIN 25MG TAB · NORPRAMIN 50MG TAB · NORPRAMIN 75MG TAB · NORPRAMIN TAB 25MG · NORPRAMIN TAB 50MG · NORPRAMIN TAB 75MG · NOVO-DESIPRAMINE FC - 50MG TAB · NOVO-DESIPRAMINE SC - TAB 10MG · NOVO-DESIPRAMINE SC - TAB 25MG · NOVO-DESIPRAMINE SC -TAB 75MG · PENTA-DESIPRAMINE TABLETS · PERTOFRANE 25MG · PERTOFRANE TAB 50MG · PHL-DESIPRAMINE · PMS DESIPRAMINE HYDRO TAB 10MG · PMS DESIPRAMINE HYDRO TAB 25MG · PMS DESIPRAMINE HYDRO TAB 50MG · PMS DESIPRAMINE HYDRO TAB 75MG · PMS-DESIPRAMINE - TAB 100MG · RATIO-DESIPRAMINE TAB 100MG · RATIO-DESIPRAMINE TAB 10MG · RATIO-DESIPRAMINE TAB 25MG · RATIO-DESIPRAMINE TAB 50MG · RATIO-DESIPRAMINE TAB 75MG | 49 | 5 | Yes |
| Clomipramine | ACT CLOMIPRAMINE · ALTIUS-CLOMIPRAMINE · ANAFRANIL · APO-CLOMIPRAMINE · CLOMIPRAMINE TABLETS 10MG · CLOMIPRAMINE TABLETS 25MG · CLOMIPRAMINE TABLETS 50MG · CLOMIPRAMINE-10 - TAB 10MG · CLOMIPRAMINE-25 - TAB 25MG · CLOMIPRAMINE-50 - TAB 50MG · DOM-CLOMIPRAMINE · GEN-CLOMIPRAMINE - TAB 10MG · GEN-CLOMIPRAMINE - TAB 25MG · GEN-CLOMIPRAMINE - TAB 50MG · MED CLOMIPRAMINE TABLETS - 25MG · MED CLOMIPRAMINE TABLETS - 50MG · NOVO-CLOPAMINE TAB 10MG · NOVO-CLOPAMINE TABLETS - 25MG · NOVO-CLOPAMINE TABLETS- 50MG · PENTA-CLOMIPRAMINE - 25MG · PENTA-CLOMIPRAMINE - 50MG · PMS-CLOMIPRAMINE · TARO-CLOMIPRAMINE | 35 | 5 | Yes |
| Trimipramine | APO-TRIMIPRAMINE · NOVO-TRIPRAMINE TAB 100MG BP · NOVO-TRIPRAMINE TAB 25MG BP · NOVO-TRIPRAMINE TAB 50MG BP · NU-TRIMIPRAMINE TAB 100MG · NU-TRIMIPRAMINE TAB 12.5MG · NU-TRIMIPRAMINE TAB 25MG · NU-TRIMIPRAMINE TAB 50MG · RHOTRIMINE · SURMONTIL · SURMONTIL 100 · SURMONTIL 12.5 · SURMONTIL 75 · TRIMIPRAMINE · TRIMIPRAMINE TAB 100MG · TRIMIPRAMINE TAB 12.5MG · TRIMIPRAMINE TAB 25MG · TRIMIPRAMINE TAB 50MG · TRIMIPRAMINE-75 - CAP 75MG | 32 | 5 | Yes |
| Nortriptyline | APO-NORTRIPTYLINE · AVA-NORTRIPTYLINE · AVENTYL · DOM-NORTRIPTYLINE 10MG CAPSULES · DOM-NORTRIPTYLINE 25MG CAPSULES · GEN-NORTRIPTYLINE CAPSULES 10MG · GEN-NORTRIPTYLINE CAPSULES 25MG · NORTRIPTYLINE · NORTRIPTYLINE-10 · NORTRIPTYLINE-25 · NORVENTYL · PMS-NORTRIPTYLINE · RATIO-NORTRIPTYLINE · TEVA-NORTRIPTYLINE | 24 | 2 | Yes |
| Maprotiline | LUDIOMIL TAB 10MG · LUDIOMIL TAB 25MG · LUDIOMIL TAB 50MG · LUDIOMIL TAB 75MG · NOVO-MAPROTILINE - TAB 10MG · PMS-MAPROTILINE · TEVA-MAPROTILINE | 12 | 0 | Not in Canada |
| Amoxapine | ASENDIN - TAB 100MG · ASENDIN - TAB 25MG · ASENDIN - TAB 50MG · ASENDIN TAB 100MG · ASENDIN TAB 25MG · ASENDIN TAB 50MG | 6 | 0 | Not in Canada |
| Protriptyline | TRIPTIL TAB 10MG | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC N06A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| N06AB | Citalopram · Escitalopram · Fluoxetine · Fluvoxamine · Paroxetine · Sertraline | 589 | 248 |
| N06AX | Bupropion · Desvenlafaxine · Duloxetine · Esketamine · Levomilnacipran · Mirtazapine · Nefazodone · Trazodone · Tryptophan · Venlafaxine · Vilazodone · Vortioxetine | 386 | 181 |
| N06AG | Moclobemide | 21 | 4 |
| N06AF | Tranylcypromine | 2 | 2 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is APO-TRIMIPRAMINE called?
The same molecule, Trimipramine, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Surmontil | Latin | Morocco, South Africa |
| Tydamine | Latin | South Africa |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
This product is approved by Health Canada but not yet marketed in Canada, so there is no Canadian supply to draw on today. Nexara can tell you whether it has been launched, and can look at supply from other markets where a Canadian pack is not required or where importation is permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.