PMS-LOSARTAN-HCTZ 50 MG — DIN 02392224
LOSARTAN POTASSIUM : 50 MG HYDROCHLOROTHIAZIDE : 12.5 MG · PHARMASCIENCE INC · TABLET · wholesale supply in Canada
Health Canada status: MARKETED
What is PMS-LOSARTAN-HCTZ?
PMS-LOSARTAN-HCTZ 50 MG contains LOSARTAN POTASSIUM : 50 MG HYDROCHLOROTHIAZIDE : 12.5 MG. It is listed in the Health Canada Drug Product Database under DIN 02392224, held by PHARMASCIENCE INC, supplied as TABLET for ORAL administration. Health Canada currently lists it as marketed, status dated 04-Sep-2012. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is PMS-LOSARTAN-HCTZ used for?
pms-LOSARTAN-HCTZ (losartan potassium and hydrochlorothiazide) is indicated for the treatment of essential hypertension in patients for whom combination therapy is appropriate. pms-LOSARTAN-HCTZ is not indicated as the initial therapy for essential hypertension, except in patients with severe essential hypertension (Sitting DBP ≥ 110 mmHg) for whom the benefit of a prompt blood pressure reduction exceeds the risk of initiating combination therapy in these patients.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Losartan And Diuretics cost around the world?
Losartan And Diuretics is listed on 12 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Belgium publishes a public; Greece publishes a producer price (ex-factory); Hungary publishes a producer price (ex-factory). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 3 | 118 | USD███.██ |
| Sweden | AIP (pharmacy purchase price) | 13 | 57 | SEK███.██ |
| Italy | prezzo al pubblico (classe A) | 16 | 37 | EUR███.██ |
| Greece | producer price (ex-factory) | 19 | 19 | EUR███.██ |
| Morocco | PPV (public price) | 7 | 16 | MAD███.██ |
| South Africa | single exit price | 16 | 16 | ZAR███.██ |
| Belgium | public | 12 | 12 | EUR███.██ |
| Hungary | producer price (ex-factory) | 12 | 12 | HUF███.██ |
| Slovakia | categorised final price | 5 | 8 | EUR███.██ |
| Romania | max producer price | 3 | 4 | RON███.██ |
| United Kingdom | hospital | 3 | 3 | GBP███.██ |
| Spain | PVP con IVA (public price) | 1 | 1 | EUR███.██ |
303 pack listings across 110 brand entries and 11 price bases, refreshed 05 Sep 2026. Ranges span every Losartan And Diuretics pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Losartan And Diuretics in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
18 holders have a Canadian DIN containing Losartan And Diuretics, across 53 DINs, of which 21 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| AURO PHARMA INC | 3 | 3 | AURO-LOSARTAN HCT | Sourceable in Canada |
| MINT PHARMACEUTICALS INC | 3 | 3 | MINT-LOSARTAN/HCTZ, MINT-LOSARTAN/HCTZ DS | Sourceable in Canada |
| ORGANON CANADA INC. | 3 | 3 | HYZAAR, HYZAAR DS | Sourceable in Canada |
| PHARMASCIENCE INC | 3 | 3 | PMS-LOSARTAN-HCTZ | Sourceable in Canada |
| SANDOZ CANADA INCORPORATED | 3 | 3 | SANDOZ LOSARTAN HCT, SANDOZ LOSARTAN HCT DS | Sourceable in Canada |
| SANIS HEALTH INC | 3 | 3 | LOSARTAN/HCTZ | Sourceable in Canada |
| SIVEM PHARMACEUTICALS ULC | 3 | 3 | LOSARTAN HCT, LOSARTAN HCT DS | Sourceable in Canada |
| ACTAVIS PHARMA COMPANY | 6 | 0 | ACT LOSARTAN/HCT, LOSARTAN/HCT | No marketed DIN |
| TEVA CANADA LIMITED | 4 | 0 | RATIO-LOSARTAN HCTZ, TEVA-LOSARTAN/HCTZ | No marketed DIN |
| FROSST A DIVISION OF MERCK CANADA INC | 3 | 0 | LOSARTAN/HCTZ | No marketed DIN |
| MYLAN PHARMACEUTICALS ULC | 3 | 0 | MYLAN-LOSARTAN HCTZ | No marketed DIN |
| PRO DOC LIMITEE | 3 | 0 | LOSARTAN-HCTZ | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 50 MG |
|---|---|
| Dosage form | TABLET |
| Route | ORAL |
| Pack configuration (monograph) | 50 mg/12.5 mg: Available blister packages of 30 tablets and HDPE bottles of 100 tablets. 100 mg/12.5 mg: Available blister packages of 30 tablets and HDPE bottles of 100 tablets. 100 mg/25 mg: Available in blister packages of 30 tablets and HDPE bottles of 100 tablets. |
| Storage | null |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation, because this listing covers more than one of them.
Substance and classification
| Active substance | Losartan And Diuretics |
|---|---|
| ATC code | C09DA01 |
| AHFS class | 24:32.08 ; 40:28.20 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02392224 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2392224 |
| Brand name | PMS-LOSARTAN-HCTZ |
| Generic / active ingredient | LOSARTAN POTASSIUM : 50 MG HYDROCHLOROTHIAZIDE : 12.5 MG |
| Market authorization holder | PHARMASCIENCE INC |
| Health Canada schedule | Prescription |
| ATC code | C09DA01 |
| ATC anatomical main group | C — Cardiovascular system |
| ATC therapeutic subgroup | C09DA |
| Current status | MARKETED |
| Status date | 04-Sep-2012 |
| Original market date | 2012-09-04 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
Is Losartan And Diuretics in shortage in Canada?
A Canadian shortage report is on file for a product containing this molecule: Resolved — reported by SANIS HEALTH INC, last seen 04 Sep 2026. A shortage on one presentation does not always affect every DIN of the molecule — the alternatives below list what else is marketed in Canada. Nexara can confirm current availability and identify substitutions or import options where permitted.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
21 of 53 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| AURO-LOSARTAN HCT | 100 MG | TABLET | AURO PHARMA INC | MARKETED | 02423669 |
| AURO-LOSARTAN HCT | 50 MG | TABLET | AURO PHARMA INC | MARKETED | 02423642 |
| AURO-LOSARTAN HCT | 12.5 MG | TABLET | AURO PHARMA INC | MARKETED | 02423650 |
| HYZAAR | 100 MG | TABLET | ORGANON CANADA INC. | MARKETED | 02297841 |
| HYZAAR | 50 MG | TABLET | ORGANON CANADA INC. | MARKETED | 02230047 |
| HYZAAR DS | 100 MG | TABLET | ORGANON CANADA INC. | MARKETED | 02241007 |
| LOSARTAN HCT | 50 MG | TABLET | SIVEM PHARMACEUTICALS ULC | MARKETED | 02388960 |
| LOSARTAN HCT | 100 MG | TABLET | SIVEM PHARMACEUTICALS ULC | MARKETED | 02388979 |
| LOSARTAN HCT DS | 25 MG | TABLET | SIVEM PHARMACEUTICALS ULC | MARKETED | 02388987 |
| LOSARTAN/HCTZ | 50 MG | TABLET | SANIS HEALTH INC | MARKETED | 02427648 |
2 · Same class — other molecules in ATC C09DA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Valsartan And Diuretics | APO-VALSARTAN/HCTZ · AURO-VALSARTAN HCT · AVA-VALSARTAN HCT · DIOVAN-HCT · MYLAN-VALSARTAN HCTZ · NOVO-VALSARTAN/HCTZ · PMS-VALSARTAN-HCTZ · Q-VALSARTAN HCTZ · SANDOZ VALSARTAN HCT · TEVA-VALSARTAN/HCTZ · VALSARTAN HCT · VALSARTAN-HCTZ | 63 | 32 | Yes |
| Candersartan And Diuretics | ACCEL-CANDESARTAN/HCTZ · ACT CANDESARTAN/HCT · AG-CANDESARTAN HCT · APO-CANDESARTAN/HCTZ · ATACAND PLUS · AURO-CANDESARTAN HCT · CANDESARTAN CILEXETIL AND HYDROCHLOROTHIAZIDE · CANDESARTAN CILEXETIL AND HYDROCHLOROTHIAZIDE TABLETS · CANDESARTAN HCT · CANDESARTAN-HCTZ · CANDESARTAN/HCTZ · JAMP CANDESARTAN-HCT · MAR-CANDESARTAN / HCTZ · MYLAN-CANDESARTAN HCTZ · NRA-CANDESARTAN HCTZ · PMS-CANDESARTAN-HCTZ · SANDOZ CANDESARTAN PLUS · SEPTA-CANDESARTAN HCTZ · TEVA-CANDESARTAN/HCTZ · ZINDA-CANDESARTAN/HYDROCHLOROTHIAZIDE | 49 | 22 | Yes |
| Telmisartan And Diuretics | ACH-TELMISARTAN HCTZ · ACT TELMISARTAN/HCT · AG TELMISARTAN-HCT · ALEMBIC-TELMISARTAN/HCTZ · APO-TELMISARTAN/HCTZ · AURO-TELMISARTAN HCTZ · JAMP TELMISARTAN-HCT · MICARDIS PLUS · MYLAN-TELMISARTAN HCTZ · NRA-TELMISARTAN/HCTZ · NTP-TELMISARTAN HCTZ · PENDO-TELMISARTAN-HCTZ · PMS-TELMISARTAN-HCTZ · PRO-TELMISARTAN-HCTZ · SANDOZ TELMISARTAN HCT · TARO-TELMISARTAN HCTZ · TELMISARTAN HCTZ · TELMISARTAN-HCTZ · TELMISARTAN/HCTZ · TEVA-TELMISARTAN HCTZ · VAN-TELMISARTAN-HCTZ | 42 | 22 | Yes |
| Losartan And Diuretics | ACT LOSARTAN/HCT · AG-LOSARTAN HCTZ · APO-LOSARTAN/HCTZ · AURO-LOSARTAN HCT · HYZAAR · HYZAAR DS · JAMP-LOSARTAN HCTZ · LOSARTAN HCT · LOSARTAN HCT DS · LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE · LOSARTAN-HCTZ · LOSARTAN/HCT · LOSARTAN/HCTZ · MINT-LOSARTAN/HCTZ · MINT-LOSARTAN/HCTZ DS · MYLAN-LOSARTAN HCTZ · PMS-LOSARTAN-HCTZ · RATIO-LOSARTAN HCTZ · SANDOZ LOSARTAN HCT · SANDOZ LOSARTAN HCT DS · SEPTA-LOSARTAN HCTZ · TEVA-LOSARTAN/HCTZ · VAN-LOSARTAN-HCTZ | 53 | 21 | Yes |
| Olmesartan Medoxomil And Diuretics | ACH-OLMESARTAN HCTZ · AG-OLMESARTAN HCTZ · APO-OLMESARTAN/HCTZ · AURO-OLMESARTAN HCTZ · GLN-OLMESARTAN HCTZ · JAMP-OLMESARTAN HCTZ · NRA-OLMESARTAN HCTZ · OLMESARTAN MEDOXOMIL / HYDROCHLOROTHIAZIDE · OLMESARTAN/HCTZ · OLMETEC PLUS · PMS-OLMESARTAN-HCTZ · PRZ-OLMESARTAN/HCTZ · SANDOZ OLMESARTAN HCTZ · TEVA-OLMESARTAN / HCTZ · TEVA-OLMESARTAN/HCTZ | 45 | 21 | Yes |
| Irbesartan And Diuretics | ACT IRBESARTAN/HCT · AG-IRBESARTAN HCTZ · APO-IRBESARTAN/HCTZ · AURO-IRBESARTAN HCT · AVA-IRBESARTAN/HCTZ · AVALIDE · DOM-IRBESARTAN-HCTZ · IRBESARTAN AND HYDROCHLOROTHIAZIDE · IRBESARTAN HCT · IRBESARTAN-HCTZ · IRBESARTAN/HCT · IRBESARTAN/HCTZ · JAMP-IRBESARTAN AND HYDROCHLOROTHIAZIDE · MINT-IRBESARTAN/HCTZ · MYLAN-IRBESARTAN HCTZ · NTP-IRBESARTAN/HCTZ · PENDO-IRBESARTAN-HCTZ · PMS-IRBESARTAN-HCTZ · RAN-IRBESARTAN HCTZ · SANDOZ IRBESARTAN HCT · TEVA-IRBESARTAN HCTZ · TEVA-IRBESARTAN/HCTZ · VAN-IRBESARTAN-HCTZ | 67 | 17 | Yes |
| Azilsartant Medoximil And Diuretics | EDARBYCLOR | 3 | 2 | Yes |
| Eprosartan And Diuretics | TEVETEN PLUS | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC C09D
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| C09DB | Telmisartan And Amlodipine | 12 | 8 |
| C09DX | Valsartan And Sacubitril | 6 | 6 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is PMS-LOSARTAN-HCTZ called?
The same molecule, Losartan And Diuretics, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Losartan Medical Valley | Latin | Sweden |
| Losartan Krka | Latin | Sweden |
| Losartan Teva | Latin | Sweden |
| Losartan/Hydrochlorothiazide Krka | Latin | Sweden |
| Losartan Viatris | Latin | Sweden |
| Losartan/Hydrochlorothiazide Medical Valley | Latin | Sweden |
| LOSARTAN GT | Latin | Morocco |
| Losartan STADA | Latin | Sweden |
| Losartan/Hydrochlorothiazide Teva | Latin | Sweden |
| COZAAR | Latin | Morocco |
| ANGINIB | Latin | Morocco |
| LACINE | Latin | Morocco |
| Losarstad Comp | Latin | Sweden |
| Losartan Sandoz | Latin | Sweden |
| Losartan/Hydrochlorothiazide STADA | Latin | Sweden |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.