ITCH RELIEF CREAM 2 % — DIN 02321076
DIPHENHYDRAMINE HYDROCHLORIDE : 2 % · CELLCHEM PHARMACEUTICALS INC. · CREAM · wholesale supply in Canada
Health Canada status: APPROVED
What is ITCH RELIEF CREAM?
ITCH RELIEF CREAM 2 % contains DIPHENHYDRAMINE HYDROCHLORIDE : 2 %. It is listed in the Health Canada Drug Product Database under DIN 02321076, held by CELLCHEM PHARMACEUTICALS INC., supplied as CREAM for TOPICAL administration. Health Canada currently lists it as approved, status dated 20-Dec-2019. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A). This DIN is not currently being marketed in Canada, so it is sourced to order where a compliant route exists rather than held in stock.
How much does Diphenhydramine cost around the world?
Diphenhydramine is listed on 5 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Morocco publishes a PPV (public price); Saudi Arabia publishes a public; South Africa publishes a single exit price. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 5 | 24 | USD███.██ |
| South Africa | single exit price | 2 | 3 | ZAR███.██ |
| United Arab Emirates | public | 2 | 2 | AED███.██ |
| Morocco | PPV (public price) | 1 | 1 | MAD███.██ |
| Saudi Arabia | public | 1 | 1 | SAR███.██ |
31 pack listings across 11 brand entries and 4 price bases, refreshed 05 Sep 2026. Ranges span every Diphenhydramine pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Diphenhydramine in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
16 holders have a Canadian DIN containing Diphenhydramine, across 26 DINs, of which 6 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| KENVUE CANADA INC. | 2 | 2 | BENADRYL ITCH STOPPING CREAM, CHILDREN'S BENADRYL BUG BITE RELIEF | Sourceable in Canada |
| MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC | 4 | 1 | BENADRYL BUG BITE RELIEF, BENADRYL CREAM 2%, BENADRYL ITCH STOPPING GEL, BENADRYL SPRAY | Sourceable in Canada |
| TARO PHARMACEUTICALS INC | 2 | 1 | ANTI-ITCH CREAM, ANTI-ITCH PLUS CREAM | Sourceable in Canada |
| LABORATOIRE ATLAS INC | 1 | 1 | LOTION CALAMINE AVEC ANTIHISTAMINIQUE | Sourceable in Canada |
| TEVA CANADA LIMITED | 1 | 1 | CALAMINE LOTION WITH ANTIHISTAMINE | Sourceable in Canada |
| TENDER CORPORATION | 3 | 0 | ITCH RELIEF SPRAY, ITCH RELIEF STICK, THE ITCH ERASER WITH ANTIHISTAMINE | No marketed DIN |
| CELLCHEM PHARMACEUTICALS INC. | 2 | 0 | CALAMINE LOTION WITH ANTIHISTAMINE, ITCH RELIEF CREAM | No marketed DIN |
| PFIZER CANADA INC., CONSUMER HEALTHCARE DIVISION | 2 | 0 | CALADRYL CREAM, CALADRYL LOTION | No marketed DIN |
| RW CONSUMER PRODUCTS LTD | 2 | 0 | CALAMINE LOTION WITH ANTIH LOT, CALAMINE LOTION WITH ANTIHISTAMINE | No marketed DIN |
| CRLS | 1 | 0 | ANTI-ITCH DIPHENHYDRAMINE HYDROCHLORIDE CREAM | No marketed DIN |
| DEL PHARMACEUTICS (CANADA) INC. | 1 | 0 | DERMAREST PLUS - GEL | No marketed DIN |
| REGAL PHARMS, DIVISION OF BRADCAN CORPORATION | 1 | 0 | CALAMINE LOTION W ANTIHISTAMINE | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 2 % |
|---|---|
| Dosage form | CREAM |
| Route | TOPICAL |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Diphenhydramine |
|---|---|
| ATC code | D04AA32 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02321076 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2321076 |
| Brand name | ITCH RELIEF CREAM |
| Generic / active ingredient | DIPHENHYDRAMINE HYDROCHLORIDE : 2 % |
| Market authorization holder | CELLCHEM PHARMACEUTICALS INC. |
| Health Canada schedule | NON-PRESCRIPTION DRUGS |
| ATC code | D04AA32 |
| ATC anatomical main group | D — Dermatologicals |
| ATC therapeutic subgroup | D04AA |
| Current status | APPROVED |
| Status date | 20-Dec-2019 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
Is Diphenhydramine in shortage in Canada?
A Canadian shortage report is on file for a product containing this molecule: Resolved — reported by SANDOZ CANADA INCORPORATED, last seen 17 Aug 2026. A shortage on one presentation does not always affect every DIN of the molecule — the alternatives below list what else is marketed in Canada. Nexara can confirm current availability and identify substitutions or import options where permitted.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
6 of 26 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| ANTI-ITCH CREAM | 2 % | CREAM | TARO PHARMACEUTICALS INC | MARKETED | 02247560 |
| BENADRYL BUG BITE RELIEF | 0.1 % | LIQUID | MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC | MARKETED | 02280868 |
| BENADRYL ITCH STOPPING CREAM | 2 % | CREAM | KENVUE CANADA INC. | MARKETED | 02484838 |
| CALAMINE LOTION WITH ANTIHISTAMINE | 8 % | SUSPENSION | TEVA CANADA LIMITED | MARKETED | 00538493 |
| CHILDREN'S BENADRYL BUG BITE RELIEF | 0.1 % | SOLUTION | KENVUE CANADA INC. | MARKETED | 02478072 |
| LOTION CALAMINE AVEC ANTIHISTAMINIQUE | 8 % | SUSPENSION | LABORATOIRE ATLAS INC | MARKETED | 02241462 |
| ALLERGY CREAM | 0.1 % | CREAM | G&W LABORATORIES INC. | CANCELLED POST MARKET | 02246391 |
| ANTI ITCH SPRAY | 2.0 % | SPRAY | H.J. SUTTON INDUSTRIES LTD. | APPROVED | 02429721 |
| ANTI-ITCH DIPHENHYDRAMINE HYDROCHLORIDE CREAM | 2.0 % | CREAM | CRLS | APPROVED | 02401932 |
| ANTI-ITCH PLUS CREAM | 0.1 % | CREAM | TARO PHARMACEUTICALS INC | APPROVED | 02301717 |
2 · Same class — other molecules in ATC D04AA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Diphenhydramine | ALLERGY CREAM · ANTI ITCH SPRAY · ANTI-ITCH CREAM · ANTI-ITCH DIPHENHYDRAMINE HYDROCHLORIDE CREAM · +20 more | 26 | 6 | Yes |
| Promethazine | PHENERGAN CREAM 2% | 2 | 0 | Not in Canada |
| Tripelennamine | BUG BITE BALM · VAGIN-X | 2 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC D04A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| D04AB | Anesthetics For Topical Use · Benzocaine · Benzocaine, Combinations · Cinchocaine · Lidocaine · +4 more | 205 | 30 |
| D04AX | Other Antipruritics | 39 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is ITCH RELIEF CREAM called?
The same molecule, Diphenhydramine, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Sleepeze-PM | Latin | South Africa |
| Advil® Night | Latin | United Arab Emirates |
| BENADRYL | Latin | Morocco |
| Diphen-cool | Latin | United Arab Emirates |
| OTRICOLD FILM COATED TABLETS | Latin | Saudi Arabia |
| Procof | Latin | South Africa |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
This product is approved by Health Canada but not yet marketed in Canada, so there is no Canadian supply to draw on today. Nexara can tell you whether it has been launched, and can look at supply from other markets where a Canadian pack is not required or where importation is permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.