REFRESH EYE ALLERGY RELIEF 0.51 % — DIN 02315890
ANTAZOLINE PHOSPHATE : 0.51 % NAPHAZOLINE HYDROCHLORIDE : 0.051 % · ABBVIE CORPORATION · SOLUTION · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is REFRESH EYE ALLERGY RELIEF?
REFRESH EYE ALLERGY RELIEF 0.51 % contains ANTAZOLINE PHOSPHATE : 0.51 % NAPHAZOLINE HYDROCHLORIDE : 0.051 %. It is listed in the Health Canada Drug Product Database under DIN 02315890, held by ABBVIE CORPORATION, supplied as SOLUTION for OPHTHALMIC administration. Health Canada currently lists it as cancelled post market, status dated 11-Nov-2025. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
Is there a generic Naphazoline, Combinations in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
16 holders have a Canadian DIN containing Naphazoline, Combinations, across 21 DINs, of which 5 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| PRESTIGE BRANDS INC | 3 | 2 | CLEAR EYES ALLERGY, CLEAR EYES EXTRA STRENGTH REDNESS RELIEF, CLEAR EYES FOR DRY EYES PLUS REDNESS RELIEF | Sourceable in Canada |
| ALCON CANADA INC | 3 | 1 | NAPHCON A, OPTI-TEARS ALLERGY, ZINCFRIN A | Sourceable in Canada |
| BAUSCH & LOMB INC | 2 | 1 | ALLERGY EYE DROPS, SOOTHE ALLERGY | Sourceable in Canada |
| JOHNSON & JOHNSON INC | 1 | 1 | VISINE FOR ALLERGY WITH ANTIHISTAMINE | Sourceable in Canada |
| ABBOTT LABORATORIES, LIMITED | 1 | 0 | CLEAR EYES ACR BY MURINE | No marketed DIN |
| KNOLL PHARMA INC. | 1 | 0 | OPTREX PLUS DECONGESTANT EYE DROPS | No marketed DIN |
| LABORATOIRES STERIGEN INC | 1 | 0 | STERITEARS AR | No marketed DIN |
| MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC | 1 | 0 | REACTINE EYE DROPS | No marketed DIN |
| NOVARTIS OPHTHALMICS NOVARTIS PHARMACEUTICALS (CANADA) INC | 1 | 0 | VASOCON A EYE DROPS | No marketed DIN |
| OPTREX LABS LTD. | 1 | 0 | OPTREX PLUS DECONGESTANT EYE DROPS | No marketed DIN |
| PHARMA STULLN INC. | 1 | 0 | DIOPTICON A LIQ | No marketed DIN |
| SABEX INC | 1 | 0 | COLLYRE BLEU | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 0.51 % |
|---|---|
| Dosage form | SOLUTION |
| Route | OPHTHALMIC |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Naphazoline, Combinations |
|---|---|
| ATC code | S01GA51 |
| AHFS class | 84:80.00 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02315890 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2315890 |
| Brand name | REFRESH EYE ALLERGY RELIEF |
| Generic / active ingredient | ANTAZOLINE PHOSPHATE : 0.51 % NAPHAZOLINE HYDROCHLORIDE : 0.051 % |
| Market authorization holder | ABBVIE CORPORATION |
| Health Canada schedule | NON-PRESCRIPTION DRUGS |
| ATC code | S01GA51 |
| ATC anatomical main group | S — Sensory organs |
| ATC therapeutic subgroup | S01GA |
| Current status | CANCELLED POST MARKET |
| Status date | 11-Nov-2025 |
| Original market date | 2008-08-21 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
5 of 21 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| CLEAR EYES ALLERGY | 0.012 % | LIQUID | PRESTIGE BRANDS INC | MARKETED | 02248059 |
| CLEAR EYES EXTRA STRENGTH REDNESS RELIEF | 0.50 % | SOLUTION | PRESTIGE BRANDS INC | MARKETED | 02360837 |
| NAPHCON A | 0.025 % | SOLUTION | ALCON CANADA INC | MARKETED | 00481408 |
| SOOTHE ALLERGY | 0.315 % | DROPS | BAUSCH & LOMB INC | MARKETED | 00750794 |
| VISINE FOR ALLERGY WITH ANTIHISTAMINE | 0.025 % | DROPS | JOHNSON & JOHNSON INC | MARKETED | 02242764 |
| ALBALON A | .5 % | LIQUID | ALLERGAN INC | CANCELLED POST MARKET | 00433519 |
| ALLERGY EYE DROPS | 0.315 % | DROPS | BAUSCH & LOMB INC | CANCELLED POST MARKET | 02394561 |
| BLUE COLLYRIUM | 0.2 MG | LIQUID | SANDOZ CANADA INCORPORATED | CANCELLED POST MARKET | 02171937 |
| CLEAR EYES ACR BY MURINE | 0.1 MG | LIQUID | ABBOTT LABORATORIES, LIMITED | CANCELLED POST MARKET | 02232454 |
| CLEAR EYES FOR DRY EYES PLUS REDNESS RELIEF | 0.012 % | SOLUTION | PRESTIGE BRANDS INC | CANCELLED POST MARKET | 02294958 |
2 · Same class — other molecules in ATC S01GA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Tetryzoline, Combinations | 8-SYMPTOM RELIEF · ADVANCED RELIEF EYE DROPS · ALLERGY EYE DROPS · CLEAR EYES TRIPLE ACTION RELIEF · COLLYRIUM EYE DROPS · RED EYE TRIPLE ACTION · RED EYE WORKPLACE · VISINE A.C. OPHTHALMIC SOL · VISINE COOL · VISINE EXTRA OPHTHALMIC SOL · VISINE FOR ALLERGY 3 SYMPTOM RELIEF · VISINE FOR RED EYE COOL · VISINE FOR RED EYE TRIPLE ACTION · VISINE FOR RED EYE WORKPLACE · VISINE MULTI-SYMPTOM | 19 | 8 | Yes |
| Naphazoline, Combinations | ALBALON A · ALLERGY EYE DROPS · BLUE COLLYRIUM · CLEAR EYES ACR BY MURINE · CLEAR EYES ALLERGY · CLEAR EYES EXTRA STRENGTH REDNESS RELIEF · CLEAR EYES FOR DRY EYES PLUS REDNESS RELIEF · COLLYRE BLEU · DIOPTICON A LIQ · NAPHCON A · OPTI-TEARS ALLERGY · OPTREX PLUS DECONGESTANT EYE DROPS · REACTINE EYE DROPS · REFRESH EYE ALLERGY RELIEF · SOOTHE ALLERGY · STERITEARS AR · VASOCON A EYE DROPS · VASOCON A OPH SOLN · VISINE FOR ALLERGY WITH ANTIHISTAMINE · ZINCFRIN A | 21 | 5 | Yes |
| Naphazoline | ALBALON · CLEAR EYES · CLEAR EYES BY MURINE EYE DPS · COLLYRE BLEU LAITER · DIOPTICON LIQ 0.1% · NAPHCON FORTE · ODAN-NAPHAZOLINE · OPCON OPH SOLN 0.1% · OPTI-TEARS RED EYE · R.O.-NAPHZ · RED AWAY · REDNESS EYE DROPS · REFRESH REDNESS RELIEF · SOOTHE REDNESS · VASOCON EYE DROPS · VASOCON OPH SOLN 0.1% | 16 | 2 | Yes |
| Tetryzoline | EYE DROPS · EYE DROPS 0.5MG/ML · ORIGINAL EYE DROPS · R.O.-EYE DROPS · VISINE ORIGINAL | 6 | 2 | Yes |
| Phenylephrine, Combinations | DIOROUGE LIQ · OCCU-CAL DROPS · OCCU-CAL LOTION · ODAN-VERNACON · PHENYLEPHRINE/HYDROXYETHYLCELLULOSE · PREFRIN A LIQ · ZINCFRIN | 7 | 0 | Not in Canada |
| Oxymetazoline | CLARITIN EYE ALLERGY RELIEF · OCUCLEAR OPH DPS 0.025% · VISINE L.R. OPHTHALMIC SOL 0.025% · VISINE WORKPLACE | 4 | 0 | Not in Canada |
| Phenylephrine | PREFRIN LIQ 0.12% | 1 | 0 | Not in Canada |
| Xylomethazoline, Combinations | OPHTRIVIN A OPHTHALMIC DPS | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC S01G
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| S01GX | Cromoglicic Acid · Emedastine · Ketotifen · Levocabastine · Lodoxamide · Nedocromil · Olopatadine | 35 | 13 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.