BREVIBLOC PREMIXED INJECTION 10 MG — DIN 02309238
ESMOLOL HYDROCHLORIDE : 10 MG · BAXTER CORPORATION · SOLUTION · wholesale supply in Canada
Health Canada status: MARKETED
What is BREVIBLOC PREMIXED INJECTION?
BREVIBLOC PREMIXED INJECTION 10 MG contains ESMOLOL HYDROCHLORIDE : 10 MG. It is listed in the Health Canada Drug Product Database under DIN 02309238, held by BAXTER CORPORATION, supplied as SOLUTION for INTRAVENOUS administration. Health Canada currently lists it as marketed, status dated 12-Sep-2008. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is BREVIBLOC PREMIXED INJECTION used for?
Perioperative management of tachycardia and hypertension; rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in acute situations. Short-term use (up to 24h).
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Esmolol cost around the world?
Esmolol is listed on 3 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Greece publishes a producer price (ex-factory); Saudi Arabia publishes a public; United Kingdom publishes a hospital. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United Kingdom | hospital | 5 | 5 | GBP███.██ |
| Greece | producer price (ex-factory) | 5 | 5 | EUR███.██ |
| Saudi Arabia | public | 3 | 3 | SAR███.██ |
13 pack listings across 13 brand entries and 3 price bases, refreshed 03 Sep 2026. Ranges span every Esmolol pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Esmolol in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
2 holders have a Canadian DIN containing Esmolol, across 5 DINs, of which 2 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| BAXTER CORPORATION | 3 | 2 | BREVIBLOC INJECTION 10MG/ML, BREVIBLOC INJECTION 250MG/ML, BREVIBLOC PREMIXED INJECTION | Sourceable in Canada |
| OHMEDA PHARMACEUTICAL PRODUCTS, DIVISION OF BOC CANADA LIMITED | 2 | 0 | BREVIBLOC LIQ IV 10MG/ML, BREVIBLOC LIQ IV 250MG/ML | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 10 MG |
|---|---|
| Dosage form | SOLUTION |
| Route | INTRAVENOUS |
| Pack configuration (monograph) | 100 mg/10 mL Vials; 2500 mg/250 mL Bags (Premixed in sodium chloride). |
| Storage | Not explicitly detailed in provided text summary (refer to full STORAGE AND STABILITY section), typically room temperature. |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Esmolol |
|---|---|
| ATC code | C07AB09 |
| AHFS class | 24:24.00 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02309238 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2309238 |
| Brand name | BREVIBLOC PREMIXED INJECTION |
| Generic / active ingredient | ESMOLOL HYDROCHLORIDE : 10 MG |
| Market authorization holder | BAXTER CORPORATION |
| Health Canada schedule | Prescription |
| ATC code | C07AB09 |
| ATC anatomical main group | C — Cardiovascular system |
| ATC therapeutic subgroup | C07AB |
| Current status | MARKETED |
| Status date | 12-Sep-2008 |
| Original market date | 2008-09-12 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Administered by intravenous injection. For perioperative tachycardia/hypertension or ventricular rate control in atrial fibrillation/flutter. Short-term use only (up to 24 hours).
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Patients requiring inotropes/vasopressors; IV calcium-channel antagonists within 24h; hypotension; sinus bradycardia; heart block (2nd/3rd degree); heart failure; cardiogenic shock.
Warnings and precautions
Monitor heart rate and blood pressure. Risk of excessive hypotension, cardiac failure, and bronchospasm. Avoid infusion into small veins to prevent serious infusion site reactions.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
2 of 5 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| BREVIBLOC INJECTION 10MG/ML | 10 MG | SOLUTION | BAXTER CORPORATION | MARKETED | 02188880 |
| BREVIBLOC INJECTION 250MG/ML | 250 MG | LIQUID | BAXTER CORPORATION | CANCELLED POST MARKET | 02188864 |
| BREVIBLOC LIQ IV 10MG/ML | 10 MG | LIQUID | OHMEDA PHARMACEUTICAL PRODUCTS, DIVISION OF BOC CANADA LIMITED | CANCELLED POST MARKET | 02053179 |
| BREVIBLOC LIQ IV 250MG/ML | 250 MG | LIQUID | OHMEDA PHARMACEUTICAL PRODUCTS, DIVISION OF BOC CANADA LIMITED | CANCELLED POST MARKET | 02053101 |
2 · Same class — other molecules in ATC C07AB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Metoprolol | AA-METOPROLOL SR · AG-METOPROLOL-L · APO-METOPROLOL · APO-METOPROLOL (TYPE L) · +44 more | 103 | 30 | Yes |
| Atenolol | ACT ATENOLOL · AG-ATENOLOL · APO-ATENOL TAB 100MG · APO-ATENOL TAB 50MG · +35 more | 87 | 28 | Yes |
| Bisoprolol | AG-BISOPROLOL · APO-BISOPROLOL · AVA-BISOPROLOL · BISOPROLOL · +19 more | 52 | 24 | Yes |
| Nebivolol | APO-NEBIVOLOL · BYSTOLIC · JAMP NEBIVOLOL · PRZ-NEBIVOLOL | 13 | 9 | Yes |
| Acebutolol | ACEBUTOLOL · ACEBUTOLOL - 400 · ACEBUTOLOL-100 · ACEBUTOLOL-200 · +20 more | 44 | 6 | Yes |
| Esmolol | BREVIBLOC INJECTION 10MG/ML · BREVIBLOC INJECTION 250MG/ML · BREVIBLOC LIQ IV 10MG/ML · BREVIBLOC LIQ IV 250MG/ML · +1 more | 5 | 2 | Yes |
| Landiolol | SIBBORAN | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC C07A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| C07AG | Carvedilol · Labetalol | 99 | 38 |
| C07AA | Nadolol · Oxprenolol · Pindolol · Propranolol · Sotalol · +1 more | 177 | 27 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is BREVIBLOC PREMIXED INJECTION called?
The same molecule, Esmolol, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Takidet | Latin | Saudi Arabia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.