FOSAVANCE 2800 UNIT — DIN 02276429
VITAMIN D3 (CHOLECALCIFEROL) : 2800 UNIT ALENDRONIC ACID (ALENDRONATE SODIUM TRIHYDRATE) : 70 MG · ORGANON CANADA INC. · TABLET · wholesale supply in Canada
Health Canada status: MARKETED
What is FOSAVANCE?
FOSAVANCE 2800 UNIT contains VITAMIN D3 (CHOLECALCIFEROL) : 2800 UNIT ALENDRONIC ACID (ALENDRONATE SODIUM TRIHYDRATE) : 70 MG. It is listed in the Health Canada Drug Product Database under DIN 02276429, held by ORGANON CANADA INC., supplied as TABLET for ORAL administration. Health Canada currently lists it as marketed, status dated 29-Jun-2022. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is FOSAVANCE used for?
Treatment of osteoporosis in postmenopausal women and in men. Increases bone mass and prevents fractures (hip and spine). Not for treating vitamin D deficiency.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Alendronic Acid And Cholecalciferol cost around the world?
Alendronic Acid And Cholecalciferol is listed on 2 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Czechia publishes a max producer price (ex-factory); Luxembourg publishes a reimbursement. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Czechia | max producer price (ex-factory) | 3 | 6 | CZK███.██ |
| Luxembourg | reimbursement | 1 | 1 | EUR███.██ |
7 pack listings across 4 brand entries and 2 price bases, refreshed 05 Sep 2026. Ranges span every Alendronic Acid And Cholecalciferol pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Alendronic Acid And Cholecalciferol in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
6 holders have a Canadian DIN containing Alendronic Acid And Cholecalciferol, across 11 DINs, of which 6 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| APOTEX INC | 2 | 2 | APO-ALENDRONATE/VITAMIN D3 | Sourceable in Canada |
| JAMP PHARMA CORPORATION | 2 | 2 | JAMP ALENDRONATE / VITAMIN D3 | Sourceable in Canada |
| ORGANON CANADA INC. | 2 | 2 | FOSAVANCE | Sourceable in Canada |
| FROSST A DIVISION OF MERCK CANADA INC | 2 | 0 | ALENDRONATE-CHOLECALCIFEROL | No marketed DIN |
| TEVA CANADA LIMITED | 2 | 0 | TEVA-ALENDRONATE/CHOLECALCIFEROL | No marketed DIN |
| SANDOZ CANADA INCORPORATED | 1 | 0 | SANDOZ ALENDRONATE/CHOLECALCIFEROL | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 2800 UNIT |
|---|---|
| Dosage form | TABLET |
| Route | ORAL |
| Pack configuration (monograph) | Blister packages of 4 tablets. |
| Storage | Not explicitly detailed in provided text snippet (Section 11 is listed in TOC but content is missing), though usually room temperature. |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Alendronic Acid And Cholecalciferol |
|---|---|
| ATC code | M05BB03 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02276429 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2276429 |
| Brand name | FOSAVANCE |
| Generic / active ingredient | VITAMIN D3 (CHOLECALCIFEROL) : 2800 UNIT ALENDRONIC ACID (ALENDRONATE SODIUM TRIHYDRATE) : 70 MG |
| Market authorization holder | ORGANON CANADA INC. |
| Health Canada schedule | Prescription |
| ATC code | M05BB03 |
| ATC anatomical main group | M — Musculo-skeletal system |
| ATC therapeutic subgroup | M05BB |
| Current status | MARKETED |
| Status date | 29-Jun-2022 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
One tablet once weekly. Take with plain water only, at least 30 minutes before first food/drink/medication. Do not lie down for 30 minutes. Do not chew/crush.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity; esophagus abnormalities (stricture, achalasia); inability to stand/sit upright for 30 min; hypocalcemia; renal insufficiency (CrCl <35 mL/min).
Warnings and precautions
Upper GI mucosal irritation (esophagitis, ulcers); osteonecrosis of the jaw; atypical femur fractures; severe musculoskeletal pain; corrected hypocalcemia before use.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
6 of 11 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| APO-ALENDRONATE/VITAMIN D3 | 2800 UNIT | TABLET | APOTEX INC | MARKETED | 02454467 |
| APO-ALENDRONATE/VITAMIN D3 | 5600 UNIT | TABLET | APOTEX INC | MARKETED | 02454475 |
| FOSAVANCE | 5600 UNIT | TABLET | ORGANON CANADA INC. | MARKETED | 02314940 |
| JAMP ALENDRONATE / VITAMIN D3 | 5600 UNIT | TABLET | JAMP PHARMA CORPORATION | MARKETED | 02519836 |
| JAMP ALENDRONATE / VITAMIN D3 | 2800 UNIT | TABLET | JAMP PHARMA CORPORATION | MARKETED | 02519828 |
| ALENDRONATE-CHOLECALCIFEROL | 2800 UNIT | TABLET | FROSST A DIVISION OF MERCK CANADA INC | CANCELLED PRE MARKET | 02405717 |
| ALENDRONATE-CHOLECALCIFEROL | 5600 UNIT | TABLET | FROSST A DIVISION OF MERCK CANADA INC | CANCELLED PRE MARKET | 02405725 |
| SANDOZ ALENDRONATE/CHOLECALCIFEROL | 5600 UNIT | TABLET | SANDOZ CANADA INCORPORATED | CANCELLED POST MARKET | 02429160 |
| TEVA-ALENDRONATE/CHOLECALCIFEROL | 70 MG | TABLET | TEVA CANADA LIMITED | DORMANT | 02403641 |
| TEVA-ALENDRONATE/CHOLECALCIFEROL | 2800 UNIT | TABLET | TEVA CANADA LIMITED | DORMANT | 02403633 |
2 · Same class — other molecules in ATC M05BB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Alendronic Acid And Cholecalciferol | ALENDRONATE-CHOLECALCIFEROL · APO-ALENDRONATE/VITAMIN D3 · FOSAVANCE · JAMP ALENDRONATE / VITAMIN D3 · +2 more | 11 | 6 | Yes |
| Etidronic Acid And Calcium, Sequential | ACT ETIDROCAL · DIDROCAL · ETIDROCAL · MYLAN-ETI-CAL CAREPAC · +2 more | 7 | 0 | Not in Canada |
| Risedronic Acid And Calcium, Sequential | ACTONEL PLUS CALCIUM · PMS-RISEDRONATE PLUS CALCIUM · TEVA-RISEDRONATE/CALCIUM | 3 | 0 | Not in Canada |
| Risedronic Acid, Calcium And Cholecalciferol, Sequential | ACTONEL SACHET KIT | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC M05B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| M05BA | Alendronic Acid · Clodronic Acid · Etidronic Acid · Ibandronic Acid · Pamidronic Acid · +2 more | 182 | 55 |
| M05BX | Burosumab · Denosumab · Romosozumab | 9 | 8 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is FOSAVANCE called?
The same molecule, Alendronic Acid And Cholecalciferol, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| VANTAVO | Latin | Czechia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.