RAPAMUNE 1 MG — DIN 02247111
SIROLIMUS : 1 MG · PFIZER CANADA ULC · TABLET · wholesale supply in Canada
Health Canada status: MARKETED
What is RAPAMUNE?
RAPAMUNE 1 MG contains SIROLIMUS : 1 MG. It is listed in the Health Canada Drug Product Database under DIN 02247111, held by PFIZER CANADA ULC, supplied as TABLET for ORAL administration. Health Canada currently lists it as marketed, status dated 28-Feb-2012. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is RAPAMUNE used for?
Rapamune (sirolimus oral solution and tablets) is indicated for the prophylaxis of organ rejection in patients receiving allogeneic renal transplants: In patients at low to moderate immunological risk, it is recommended that Rapamune be used initially in a regimen with cyclosporine and corticosteroids. In patients at high immunologic risk, it is recommended that Rapamune be used in combination with cyclosporine and corticosteroids for the first year following transplantation.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Sirolimus cost around the world?
Sirolimus is listed on 17 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Bahrain publishes a retail (max). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 4 | 34 | USD███.██ |
| South Africa | single exit price | 30 | 31 | ZAR███.██ |
| Australia | ex-manufacturer | 1 | 16 | AUD███.██ |
| Austria | KVP (Kassenverkaufspreis) | 4 | 7 | EUR███.██ |
| Iceland | max wholesale | 3 | 7 | ISK███.██ |
| Saudi Arabia | public | 4 | 5 | SAR███.██ |
| Spain | PVP con IVA (public price) | 4 | 4 | EUR███.██ |
| Hungary | producer price (ex-factory) | 4 | 4 | HUF███.██ |
| Italy | prezzo al pubblico (classe A) | 4 | 4 | EUR███.██ |
| Czechia | max producer price (ex-factory) | 1 | 3 | CZK███.██ |
| Luxembourg | reimbursement | 3 | 3 | EUR███.██ |
| United Arab Emirates | public | 1 | 1 | AED███.██ |
| Bahrain | retail (max) | 1 | 1 | BHD███.██ |
| Greece | producer price (ex-factory) | 1 | 1 | EUR███.██ |
| Norway | max AUP (pharmacy retail) | 1 | 1 | NOK███.██ |
| Romania | max producer price | 1 | 1 | RON███.██ |
| Slovakia | categorised final price | 1 | 1 | EUR███.██ |
124 pack listings across 68 brand entries and 15 price bases, refreshed 08 Sep 2026. Ranges span every Sirolimus pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Sirolimus in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
2 holders have a Canadian DIN containing Sirolimus, across 8 DINs, of which 2 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| PFIZER CANADA ULC | 4 | 2 | RAPAMUNE | Sourceable in Canada |
| GENMED A DIVISION OF PFIZER CANADA ULC | 4 | 0 | GD-SIROLIMUS | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 1 MG |
|---|---|
| Dosage form | TABLET |
| Route | ORAL |
| Pack configuration (monograph) | Oral Solution: Amber glass bottles of 60 mL. Tablet: Bottles of 100 tablets, Unit dose cartons of 100 tablets (10 blister cards of 10 tablets each). |
| Storage | null |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Sirolimus |
|---|---|
| ATC code | L04AH01 |
| AHFS class | 90:28.24.92 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02247111 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2247111 |
| Brand name | RAPAMUNE |
| Generic / active ingredient | SIROLIMUS : 1 MG |
| Market authorization holder | PFIZER CANADA ULC |
| Health Canada schedule | Prescription |
| ATC code | L04AH01 |
| ATC anatomical main group | L — Antineoplastic and immunomodulating agents |
| ATC therapeutic subgroup | L04AH |
| Current status | MARKETED |
| Status date | 28-Feb-2012 |
| Original market date | 2003-03-25 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Once daily, consistently with or without food. Take 4 hours after cyclosporine. Low/moderate risk: 6mg load, 2mg/day maintenance. High risk: 15mg load, 5mg/day maintenance.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity to sirolimus, its derivatives, or any ingredient in the formulation.
Warnings and precautions
Increased susceptibility to infection/lymphoma. Not recommended for liver/lung transplants. Risk of angioedema, hyperlipidemia, and skin cancer (limit UV exposure).
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
2 of 8 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| RAPAMUNE | 1 MG | SOLUTION | PFIZER CANADA ULC | MARKETED | 02243237 |
| GD-SIROLIMUS | 1 MG | SOLUTION | GENMED A DIVISION OF PFIZER CANADA ULC | APPROVED | 02373386 |
| GD-SIROLIMUS | 2 MG | TABLET | GENMED A DIVISION OF PFIZER CANADA ULC | CANCELLED PRE MARKET | 02373408 |
| GD-SIROLIMUS | 5 MG | TABLET | GENMED A DIVISION OF PFIZER CANADA ULC | CANCELLED PRE MARKET | 02373416 |
| GD-SIROLIMUS | 1 MG | TABLET | GENMED A DIVISION OF PFIZER CANADA ULC | APPROVED | 02373394 |
| RAPAMUNE | 5 MG | TABLET | PFIZER CANADA ULC | CANCELLED PRE MARKET | 02270684 |
| RAPAMUNE | 2 MG | TABLET | PFIZER CANADA ULC | CANCELLED PRE MARKET | 02270617 |
2 · Same class — other molecules in ATC L04AH
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Everolimus | AFINITOR · AFINITOR DISPERZ · CERTICAN · NAT-EVEROLIMUS · +4 more | 28 | 21 | Yes |
| Sirolimus | GD-SIROLIMUS · RAPAMUNE | 8 | 2 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC L04A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| L04AX | Azathioprine · Dimethyl Fumarate · Lenalidomide · Methotrexate · Other Immunosuppressants · +3 more | 191 | 124 |
| L04AC | Anakinra · Basiliximab · Bimekizumab · Brodalumab · Canakinumab · +13 more | 85 | 75 |
| L04AB | Adalimumab · Certolizumab Pegol · Etanercept · Golimumab · Infliximab | 71 | 55 |
| L04AA | Abatacept · Alefacept · Antilymphocyte Immunoglobulin (Horse) · Antithymocyte Immunoglobulin (Rabbit) · Apremilast · +4 more | 73 | 42 |
| L04AD | Ciclosporin · Tacrolimus | 49 | 30 |
| L04AK | Leflunomide · Teriflunomide | 44 | 25 |
| L04AF | Baricitinib · Deucravacitinib · Ritlecitinib · Tofacitinib · Upadacitinib | 23 | 19 |
| L04AG | Alemtuzumab · Anifrolumab · Belimumab · Efalizumab · Inebilizumab · +7 more | 20 | 15 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is RAPAMUNE called?
The same molecule, Sirolimus, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Sirolimus BOS | Latin | Saudi Arabia |
| Hyftor Gel | Latin | Iceland |
| sirolimus | Latin | Saudi Arabia |
| Siromune | Latin | Saudi Arabia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.