REMODULIN 1 MG — DIN 02246552
TREPROSTINIL (TREPROSTINIL SODIUM) : 1 MG · UNITED THERAPEUTICS CORPORATION · SOLUTION · wholesale supply in Canada
Health Canada status: MARKETED
What is REMODULIN?
REMODULIN 1 MG contains TREPROSTINIL (TREPROSTINIL SODIUM) : 1 MG. It is listed in the Health Canada Drug Product Database under DIN 02246552, held by UNITED THERAPEUTICS CORPORATION, supplied as SOLUTION for INTRAVENOUS ; SUBCUTANEOUS administration. Health Canada currently lists it as marketed, status dated 07-Oct-2005. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is REMODULIN used for?
Long-term, subcutaneous or intravenous treatment of pulmonary arterial hypertension (PAH) in NYHA Class III and IV patients who did not respond adequately to conventional therapy.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Treprostinil cost around the world?
Treprostinil is listed on 13 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Austria publishes a KVP (Kassenverkaufspreis); Bahrain publishes a retail (max); Czechia publishes a max producer price (ex-factory). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Italy | ex-factory (classe H) | 16 | 17 | EUR███.██ |
| Greece | producer price (ex-factory) | 16 | 16 | EUR███.██ |
| Sweden | AIP (pharmacy purchase price) | 3 | 11 | SEK███.██ |
| Czechia | max producer price (ex-factory) | 3 | 10 | CZK███.██ |
| Austria | KVP (Kassenverkaufspreis) | 8 | 8 | EUR███.██ |
| Romania | max producer price | 8 | 8 | RON███.██ |
| United Arab Emirates | public | 6 | 7 | AED███.██ |
| Saudi Arabia | public | 4 | 7 | SAR███.██ |
| Hungary | producer price (ex-factory) | 6 | 6 | HUF███.██ |
| Luxembourg | reimbursement | 4 | 4 | EUR███.██ |
| Bahrain | retail (max) | 1 | 3 | BHD███.██ |
| Slovakia | categorised final price | 3 | 3 | EUR███.██ |
| United Kingdom | hospital | 2 | 2 | GBP███.██ |
102 pack listings across 80 brand entries and 11 price bases, refreshed 05 Sep 2026. Ranges span every Treprostinil pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Treprostinil in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
2 holders have a Canadian DIN containing Treprostinil, across 8 DINs, of which 4 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| UNITED THERAPEUTICS CORPORATION | 4 | 4 | REMODULIN | Sourceable in Canada |
| DR REDDY'S LABORATORIES LTD | 4 | 0 | TREPROSTINIL INJECTION | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 1 MG |
|---|---|
| Dosage form | SOLUTION |
| Route | INTRAVENOUS ; SUBCUTANEOUS |
| Pack configuration (monograph) | Not explicitly detailed in provided text beyond vial strengths; typically multi-dose vials. |
| Storage | During use, a single reservoir of undiluted Remodulin can be administered up to 72 hours at 37°C. (General storage not in provided snippet). |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Treprostinil |
|---|---|
| ATC code | B01AC21 |
| AHFS class | 48:48.00 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02246552 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2246552 |
| Brand name | REMODULIN |
| Generic / active ingredient | TREPROSTINIL (TREPROSTINIL SODIUM) : 1 MG |
| Market authorization holder | UNITED THERAPEUTICS CORPORATION |
| Health Canada schedule | Prescription |
| ATC code | B01AC21 |
| ATC anatomical main group | B — Blood and blood-forming organs |
| ATC therapeutic subgroup | B01AC |
| Current status | MARKETED |
| Status date | 07-Oct-2005 |
| Original market date | 2004-04-30 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Initial: 1.25 ng/kg/min. Increase by 1.25 ng/kg/min per week for 4 weeks, then 2.5 ng/kg/min per week. Administered via continuous SC or IV infusion. Avoid abrupt withdrawal.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Known hypersensitivity to the drug, any of its excipients, or to structurally related compounds.
Warnings and precautions
Potent vasodilator. Abrupt withdrawal may cause worsening of PAH. IV route associated with risk of fatal blood stream infections/sepsis; SC is preferred. Use caution in hepatic/renal impairment.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
4 of 8 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| REMODULIN | 2.5 MG | SOLUTION | UNITED THERAPEUTICS CORPORATION | MARKETED | 02246553 |
| REMODULIN | 5 MG | SOLUTION | UNITED THERAPEUTICS CORPORATION | MARKETED | 02246554 |
| REMODULIN | 10 MG | SOLUTION | UNITED THERAPEUTICS CORPORATION | MARKETED | 02246555 |
| TREPROSTINIL INJECTION | 1 MG | SOLUTION | DR REDDY'S LABORATORIES LTD | APPROVED | 02523841 |
| TREPROSTINIL INJECTION | 2.5 MG | SOLUTION | DR REDDY'S LABORATORIES LTD | APPROVED | 02523868 |
| TREPROSTINIL INJECTION | 5 MG | SOLUTION | DR REDDY'S LABORATORIES LTD | APPROVED | 02523876 |
| TREPROSTINIL INJECTION | 10 MG | SOLUTION | DR REDDY'S LABORATORIES LTD | APPROVED | 02523884 |
2 · Same class — other molecules in ATC B01AC
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Clopidogrel | ABBOTT-CLOPIDOGREL · ACCEL-CLOPIDOGREL · ACT CLOPIDOGREL · AG-CLOPIDOGREL · +22 more | 39 | 19 | Yes |
| Acetylsalicylic Acid | APO-ASA LD · ASA · ASA 81 MG · ASA DAILY LOW DOSE · +17 more | 23 | 12 | Yes |
| Ticagrelor | AG-TICAGRELOR · APO-TICAGRELOR · BRILINTA · JAMP TICAGRELOR · +3 more | 14 | 12 | Yes |
| Selexipag | UPTRAVI | 8 | 8 | Yes |
| Treprostinil | REMODULIN · TREPROSTINIL INJECTION | 8 | 4 | Yes |
| Epoprostenol | CARIPUL · EPOPROSTENOL FOR INJECTION · FLOLAN | 6 | 4 | Yes |
| Dipyridamole | APO-DIPYRIDAMOLE · APO-DIPYRIDAMOLE-SC TAB 25MG · APO-DIPYRIDAMOLE-SC TAB 50MG · APO-DIPYRIDAMOLE-SC TAB 75MG · +17 more | 24 | 2 | Yes |
| Eptifibatide | EPTIFIBATIDE INJECTION · INTEGRILIN | 14 | 2 | Yes |
| Tirofiban | AGGRASTAT | 2 | 1 | Yes |
| Prasugrel | EFFIENT · JAMP PRASUGREL | 2 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC B01A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| B01AF | Apixaban · Edoxaban · Rivaroxaban | 159 | 121 |
| B01AB | Antithrombin · Dalteparin · Danaparoid · Enoxaparin · Heparin · +3 more | 128 | 82 |
| B01AA | Acenocoumarol · Warfarin | 62 | 16 |
| B01AE | Argatroban · Bivalirudin · Dabigatran Etexilate · Lepirudin | 18 | 11 |
| B01AX | Caplacizumab · Defibrotide · Fondaparinux | 10 | 5 |
| B01AD | Alteplase · Ancrod · Anistreplase · Drotrecogin Alfa · Reteplase · +3 more | 22 | 4 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is REMODULIN called?
Also recorded in Canada as: Orenitram (US), Tyvaso (US), Treprostinil Sodium (US), Treprostinil Sodium (JP), Treprostinil Sodium (UK), Remoxy (IN), Treprostinil Injection (GLOBAL).
The same molecule, Treprostinil, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Treprostinil Tillomed | Latin | Bahrain, Saudi Arabia, Sweden |
| Tresuvi | Latin | Czechia, Sweden |
| TREPULMIX | Latin | Czechia |
| Trisuva | Latin | Saudi Arabia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.