CLASTEON 400 MG
CLODRONATE DISODIUM : 400 MG · DIN 02245828 · SUMITOMO PHARMA CANADA, INC.
Health Canada status: MARKETED
What is CLASTEON?
CLASTEON 400 MG contains CLODRONATE DISODIUM : 400 MG. It is listed in the Health Canada Drug Product Database under DIN 02245828, held by SUMITOMO PHARMA CANADA, INC., supplied as CAPSULE for ORAL administration. Health Canada currently lists it as marketed, status dated 07-Nov-2025. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is CLASTEON used for?
CLASTEON (clodronate disodium) is indicated as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors and for the management of hypercalcemia of malignancy. It inhibits osteoclastic activity and bone resorption by decreasing the flux of calcium from the bones, thereby reducing blood calcium levels.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
Product details and regulatory record
| DIN | 02245828 |
|---|---|
| Brand name | CLASTEON |
| Generic / active ingredient | CLODRONATE DISODIUM : 400 MG |
| Manufacturer | SUMITOMO PHARMA CANADA, INC. |
| Strength | 400 MG |
| Dosage form | CAPSULE |
| Route of administration | ORAL |
| Schedule | Prescription |
| ATC code | M05BA02 CLODRONIC ACID |
| AHFS class | 92:24.00 |
| Biosimilar | No |
| Health Canada status | MARKETED |
| Status date | 07-Nov-2025 |
| Original market date | 2004-05-13 00:00:00 |
How is it administered?
1600 mg to 2400 mg daily in single or two divided doses. Max 3200 mg/day. Take whole with fluids (not milk), 1 hour before/after food. Do not lie down for 30 mins.
Included because it drives pack selection and wastage. Consult the monograph.
How is it stored and handled?
store at room temperature (15-30 °C). Protect from high humidity.
How is it supplied?
blister packs of 120 capsules per box. Boxes of 120 capsules contain 12 blister strips (10 capsules/blister strip).
Contraindications
Renal impairment (creatinine > 440 μmol/L), hypersensitivity to bisphosphonates, severe GI inflammation, pregnancy and lactation.
Warnings and precautions
Risk of osteonecrosis of the jaw (ONJ), atypical femur fractures, esophageal reactions, renal aggravation, and ocular disturbances (uveitis, scleritis). Caution in ASA-sensitive asthma.
What can be used instead?
Other Canadian products sharing ATC code M05BA02 CLODRONIC ACID. 1 of 4 DINs in this group are currently marketed — marketed products are listed first, because that is what can actually be bought. These tables describe supply, not clinical equivalence: substitution rests with the prescriber or pharmacist, and interchangeability is determined provincially.
| Product | Strength | Form | Manufacturer | Health Canada status | DIN |
|---|---|---|---|---|---|
| BONEFOS | 400 MG | CAPSULE | BAYER INC | CANCELLED POST MARKET | DIN 01984845 |
| BONEFOS | 60 MG | SOLUTION | BAYER INC | CANCELLED POST MARKET | DIN 01984837 |
| OSTAC CAP 400MG | 400 MG | CAPSULE | HOFFMANN-LA ROCHE LIMITED | CANCELLED POST MARKET | DIN 01927078 |
Who else supplies CLODRONIC ACID worldwide?
Nexara tracks national medicine registries and published price lists across multiple markets. CLODRONIC ACID appears in 3 registered pack listings across 2 markets, published on 2 different national price bases. Where a Canadian route is closed, that is where an alternative route of supply starts — subject to the import rules in both countries.
Registered listings are not stock. Ask us to confirm what can actually be sourced for your order.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.