APO-CYCLOSPORINE ORAL SOLUTION 100 MG
CYCLOSPORINE : 100 MG · DIN 02244324 · APOTEX INC
Health Canada status: CANCELLED POST MARKET
What is APO-CYCLOSPORINE ORAL SOLUTION?
APO-CYCLOSPORINE ORAL SOLUTION 100 MG contains CYCLOSPORINE : 100 MG. It is listed in the Health Canada Drug Product Database under DIN 02244324, held by APOTEX INC, supplied as SOLUTION for ORAL administration. Health Canada currently lists it as cancelled post market, status dated 11-Jan-2018. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is APO-CYCLOSPORINE ORAL SOLUTION used for?
APO-CYCLOSPORINE ORAL SOLUTION is indicated in the prevention of graft rejection following solid organ transplantation and in the treatment of transplant rejection in patients previously receiving other immunosuppressive agents. It is also indicated in the prevention of graft rejection following bone marrow transplantation and the prevention or treatment of graft-versus-host disease (GVHD). Additionally, it is indicated for the treatment of severe psoriasis, severe active rheumatoid arthritis, and steroid dependent and steroid resistant nephrotic syndrome due to glomerular diseases.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
What else is APO-CYCLOSPORINE ORAL SOLUTION called?
The same molecule, CICLOSPORIN, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| APO-Ciclosporin | Latin | Australia |
| CICLOSPORIN-WGR | Latin | Australia |
| Sandimmun | Latin | Australia, South Africa |
| Atopica vet. | Latin | Iceland |
| Ikervis | Latin | Australia, Czechia, Iceland |
| Neoral | Latin | Australia |
| SANDIMMUN NEORAL | Latin | Bahrain |
| VERKAZIA | Latin | Bahrain, Saudi Arabia |
| Sporimune vet. | Latin | Iceland |
| Cequa | Latin | Australia |
| Ciclohexal Oral Solution | Latin | South Africa |
| CLASGEN | Latin | Saudi Arabia |
| Optimmune vet. | Latin | Iceland |
| Restasis | Latin | Iceland |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
Product details and regulatory record
| DIN | 02244324 |
|---|---|
| Brand name | APO-CYCLOSPORINE ORAL SOLUTION |
| Generic / active ingredient | CYCLOSPORINE : 100 MG |
| Manufacturer | APOTEX INC |
| Strength | 100 MG |
| Dosage form | SOLUTION |
| Route of administration | ORAL |
| Schedule | Prescription |
| ATC code | L04AD01 CICLOSPORIN |
| AHFS class | 90:28.28.92 |
| Biosimilar | No |
| Health Canada status | CANCELLED POST MARKET |
| Status date | 11-Jan-2018 |
| Original market date | 2002-07-30 00:00:00 |
How is this product identified?
Purchase orders, customs paperwork and tender documents each ask for a different identifier, and a DIN written without its leading zeros is the single most common reason an order line fails to match. Every form Nexara accepts for this product is listed here.
| DIN (8-digit, as used in Nexara ordering) | 02244324 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2244324 |
| Brand name | APO-CYCLOSPORINE ORAL SOLUTION |
| Active ingredient / INN | CYCLOSPORINE : 100 MG |
| ATC code | L04AD01 |
| ATC anatomical main group | L — Antineoplastic and immunomodulating agents |
| ATC therapeutic subgroup | L04 |
| AHFS class | 90:28.28.92 |
| Health Canada schedule | Prescription |
| Biosimilar biologic | No |
| Market authorization holder | APOTEX INC |
How is it stored and handled?
Samples which are not to be analyzed immediately should be stored in a refrigerator (4°C) and assayed within 7 days; if the samples are to be kept longer they should be deep frozen (-20°C) for up to 6 months.
How is it supplied?
null
Which pack is which?
| Strength on the label | 100 MG |
|---|---|
| Dosage form | SOLUTION |
| Route | ORAL |
| Packaging as described in the monograph | null |
| Storage | Samples which are not to be analyzed immediately should be stored in a refrigerator (4°C) and assayed within 7 days; if the samples are to be kept longer they should be deep frozen (-20°C) for up to 6 months. |
One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced. Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Cold chain. This product is stored refrigerated. Nexara ships it on a validated cold chain with temperature monitoring; a delivery address that cannot receive and store it at 2–8 °C on arrival must be flagged before the order is placed.
What can be used instead?
Other Canadian products sharing ATC code L04AD01 CICLOSPORIN. 9 of 18 DINs in this group are currently marketed — marketed products are listed first, because that is what can actually be bought. These tables describe supply, not clinical equivalence: substitution rests with the prescriber or pharmacist, and interchangeability is determined provincially.
| Product | Strength | Form | Manufacturer | Health Canada status | DIN |
|---|---|---|---|---|---|
| NEORAL | 10 MG | CAPSULE | NOVARTIS PHARMACEUTICALS CANADA INC | MARKETED | DIN 02237671 |
| NEORAL | 100 MG | SOLUTION | NOVARTIS PHARMACEUTICALS CANADA INC | MARKETED | DIN 02150697 |
| NEORAL | 100 MG | CAPSULE | NOVARTIS PHARMACEUTICALS CANADA INC | MARKETED | DIN 02150670 |
| NEORAL | 25 MG | CAPSULE | NOVARTIS PHARMACEUTICALS CANADA INC | MARKETED | DIN 02150689 |
| NEORAL | 50 MG | CAPSULE | NOVARTIS PHARMACEUTICALS CANADA INC | MARKETED | DIN 02150662 |
| SANDIMMUNE I.V. | 50 MG | SOLUTION | NOVARTIS PHARMACEUTICALS CANADA INC | MARKETED | DIN 00593257 |
| SANDOZ CYCLOSPORINE | 100 MG | CAPSULE | SANDOZ CANADA INCORPORATED | MARKETED | DIN 02242821 |
| SANDOZ CYCLOSPORINE | 25 MG | CAPSULE | SANDOZ CANADA INCORPORATED | MARKETED | DIN 02247073 |
| SANDOZ CYCLOSPORINE | 50 MG | CAPSULE | SANDOZ CANADA INCORPORATED | MARKETED | DIN 02247074 |
| CYCLOSPORINE | 100 MG | CAPSULE | EDENBRIDGE PHARMACEUTICALS, LLC | DORMANT | DIN 02495813 |
Who else supplies CICLOSPORIN worldwide?
Nexara tracks national medicine registries and published price lists across multiple markets. CICLOSPORIN appears in 219 registered pack listings across 11 markets, published on 9 different national price bases. Where a Canadian route is closed, that is where an alternative route of supply starts — subject to the import rules in both countries.
Registered listings are not stock. Ask us to confirm what can actually be sourced for your order.
How much does CICLOSPORIN cost around the world?
CICLOSPORIN is listed on 11 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Bahrain publishes a retail (max). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Australia | ex-manufacturer | 10 | 48 | AUD███.██ |
| Saudi Arabia | public | 11 | 13 | SAR███.██ |
| Greece | producer price (ex-factory) | 10 | 10 | EUR███.██ |
| Iceland | max wholesale | 5 | 10 | ISK███.██ |
| United Arab Emirates | public | 6 | 7 | AED███.██ |
| South Africa | single exit price | 4 | 7 | ZAR███.██ |
| Bahrain | retail (max) | 2 | 6 | BHD███.██ |
| Romania | max producer price | 3 | 5 | RON███.██ |
| Austria | KVP (Kassenverkaufspreis) | 2 | 2 | EUR███.██ |
| Czechia | max producer price (ex-factory) | 1 | 1 | CZK███.██ |
| Hungary | producer price (ex-factory) | 1 | 1 | HUF███.██ |
110 pack listings across 55 brand entries and 9 price bases, refreshed 08 Sep 2026. Ranges span every CICLOSPORIN pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.