EPREX STERILE SOLUTION 20000 UNIT / 0.5 ML — DIN 02243239
EPOETIN ALFA : 20000 UNIT / 0.5 ML · JANSSEN INC · SOLUTION · wholesale supply in Canada
Health Canada status: MARKETED
What is EPREX STERILE SOLUTION?
EPREX STERILE SOLUTION 20000 UNIT / 0.5 ML contains EPOETIN ALFA : 20000 UNIT / 0.5 ML. It is listed in the Health Canada Drug Product Database under DIN 02243239, held by JANSSEN INC, supplied as SOLUTION for INTRAVENOUS ; SUBCUTANEOUS administration. Health Canada currently lists it as marketed, status dated 24-Aug-2005. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is EPREX STERILE SOLUTION used for?
Treatment of anemia associated with chronic renal failure, zidovudine-treated HIV, and non-myeloid malignancies receiving chemotherapy. Also used to reduce allogeneic blood transfusions in surgery.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Erythropoietin cost around the world?
Erythropoietin is listed on 2 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Greece publishes a producer price (ex-factory); South Africa publishes a single exit price. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Greece | producer price (ex-factory) | 22 | 22 | EUR███.██ |
| South Africa | single exit price | 12 | 18 | ZAR███.██ |
40 pack listings across 34 brand entries and 2 price bases, refreshed 03 Sep 2026. Ranges span every Erythropoietin pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Erythropoietin in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
Only one market authorization holder has a Canadian DIN containing Erythropoietin — 15 DINs, of which 11 are currently marketed. There is no second Canadian source today, so a supply interruption on this holder has no domestic substitute at the same molecule.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| JANSSEN INC | 15 | 11 | EPREX STERILE SOLUTION, EPREX STERILE SOLUTION 10000IU/1.0ML, EPREX STERILE SOLUTION 10000IU/ML, EPREX STERILE SOLUTION 1000IU/0.5ML, EPREX STERILE SOLUTION 20000IU/ML, +9 more | Sourceable in Canada |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 20000 UNIT / 0.5 ML |
|---|---|
| Dosage form | SOLUTION |
| Route | INTRAVENOUS ; SUBCUTANEOUS |
| Pack configuration (monograph) | Single-use pre-filled syringes with PROTECS needle guard and peelable label for tracking. |
| Storage | Not explicitly detailed in provided text snippet (standard is usually 2-8°C, do not freeze/shake). |
| Shipping class | Cold chain — validated shipper with temperature monitoring |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation, because this listing covers more than one of them.
Cold chain. This product is stored refrigerated. Nexara ships it on a validated cold chain with temperature monitoring; a delivery address that cannot receive and store it at 2–8 °C on arrival must be flagged before the order is placed.
Substance and classification
| Active substance | Erythropoietin |
|---|---|
| ATC code | B03XA01 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02243239 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2243239 |
| Brand name | EPREX STERILE SOLUTION |
| Generic / active ingredient | EPOETIN ALFA : 20000 UNIT / 0.5 ML |
| Market authorization holder | JANSSEN INC |
| Health Canada schedule | Prescription |
| ATC code | B03XA01 |
| ATC anatomical main group | B — Blood and blood-forming organs |
| ATC therapeutic subgroup | B03XA |
| Current status | MARKETED |
| Status date | 24-Aug-2005 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Individualize dose to maintain Hb 100-115 g/L (max 120 g/L). CRF: 50-100 IU/kg TIW. Cancer: 150 IU/kg TIW or 40,000 IU QW. Surgery: 600 IU/kg weekly for 3 weeks before surgery.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Pure red cell aplasia (PRCA) after any ESA; uncontrolled hypertension; hypersensitivity to mammalian cell-derived products; patients unable to receive antithrombotic treatment.
Warnings and precautions
Increased risk of death, serious cardiovascular events, and stroke. Risk of tumor progression in cancer patients. Pure red cell aplasia (PRCA) reported. Use caution with history of seizures.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
11 of 15 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| EPREX STERILE SOLUTION | 30000 UNIT / 0.75 ML | SOLUTION | JANSSEN INC | MARKETED | 02288680 |
| EPREX STERILE SOLUTION 10000IU/1.0ML | 10000 UNIT | SOLUTION | JANSSEN INC | MARKETED | 02231587 |
| EPREX STERILE SOLUTION 1000IU/0.5ML | 1000 UNIT / 0.5 ML | SOLUTION | JANSSEN INC | MARKETED | 02231583 |
| EPREX STERILE SOLUTION 2000IU/0.5ML | 2000 UNIT / 0.5 ML | SOLUTION | JANSSEN INC | MARKETED | 02231584 |
| EPREX STERILE SOLUTION 3000IU/0.3ML | 3000 UNIT / 0.3 ML | SOLUTION | JANSSEN INC | MARKETED | 02231585 |
| EPREX STERILE SOLUTION 40000IU/ML | 40000 UNIT | SOLUTION | JANSSEN INC | MARKETED | 02240722 |
| EPREX STERILE SOLUTION 4000IU/0.4ML | 4000 UNIT / 0.4 ML | SOLUTION | JANSSEN INC | MARKETED | 02231586 |
| EPREX STERILE SOLUTION 5000IU/0.5ML | 5000 UNIT / 0.5 ML | SOLUTION | JANSSEN INC | MARKETED | 02243400 |
| EPREX STERILE SOLUTION 6000 IU/0.6 ML | 6000 UNIT / 0.6 ML | SOLUTION | JANSSEN INC | MARKETED | 02243401 |
| EPREX STERILE SOLUTION 8000 IU/0.8 ML | 8000 UNIT / 0.8 ML | SOLUTION | JANSSEN INC | MARKETED | 02243403 |
2 · Same class — other molecules in ATC B03XA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Darbepoetin Alfa | ARANESP · ARANESP -(HSA-FREE) | 24 | 13 | Yes |
| Erythropoietin | EPREX STERILE SOLUTION · EPREX STERILE SOLUTION 10000IU/1.0ML · EPREX STERILE SOLUTION 10000IU/ML · EPREX STERILE SOLUTION 1000IU/0.5ML · +10 more | 15 | 11 | Yes |
| Luspatercept | REBLOZYL | 2 | 2 | Yes |
| Methoxy Polyethylene Glycol-Epoetin Beta | MIRCERA | 15 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is EPREX STERILE SOLUTION called?
The same molecule, Erythropoietin, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Recormon Pre-Filled | Latin | South Africa |
| Eprex Prefill | Latin | South Africa |
| Recormon | Latin | South Africa |
| Recormon Vials | Latin | South Africa |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.