ENBREL 1 ML — DIN 02242903
WATER : 1 ML ETANERCEPT : 25 MG · IMMUNEX CORPORATION · LIQUID ; POWDER FOR SOLUTION ; KIT · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is ENBREL?
ENBREL 1 ML contains WATER : 1 ML ETANERCEPT : 25 MG. It is listed in the Health Canada Drug Product Database under DIN 02242903, held by IMMUNEX CORPORATION, supplied as LIQUID ; POWDER FOR SOLUTION ; KIT for SUBCUTANEOUS administration. Health Canada currently lists it as cancelled post market, status dated 31-Jan-2023. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
What is ENBREL used for?
ENBREL is indicated for the treatment of moderately to severely active rheumatoid arthritis (RA) in adults, reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in patients aged 4 to 17 years, reducing signs and symptoms and inhibiting the progression of structural damage of active arthritis and improving physical function in adult patients with psoriatic arthritis (PsA), reducing signs and symptoms of active ankylosing spondylitis (AS), treatment of adult patients with chronic moderate to severe plaque psoriasis (PsO) who are candidates for systemic therapy or phototherapy, and treatment of pediatric patients ages 4 to 17 years with chronic severe PsO who are candidates for systemic therapy or phototherapy.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Etanercept cost around the world?
Etanercept is listed on 15 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Bahrain publishes a retail (max). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Australia | ex-manufacturer | 4 | 177 | AUD███.██ |
| Norway | max AUP (pharmacy retail) | 3 | 16 | NOK███.██ |
| Luxembourg | reimbursement | 15 | 15 | EUR███.██ |
| Czechia | max producer price (ex-factory) | 5 | 13 | CZK███.██ |
| Greece | producer price (ex-factory) | 12 | 12 | EUR███.██ |
| Italy | ex-factory (classe H) | 12 | 12 | EUR███.██ |
| Hungary | producer price (ex-factory) | 11 | 11 | HUF███.██ |
| Iceland | max wholesale | 3 | 11 | ISK███.██ |
| Slovakia | categorised final price | 11 | 11 | EUR███.██ |
| Austria | KVP (Kassenverkaufspreis) | 10 | 10 | EUR███.██ |
| Saudi Arabia | public | 5 | 10 | SAR███.██ |
| United Arab Emirates | public | 4 | 9 | AED███.██ |
| Bahrain | retail (max) | 3 | 9 | BHD███.██ |
| Romania | max producer price | 5 | 8 | RON███.██ |
| South Africa | single exit price | 5 | 7 | ZAR███.██ |
331 pack listings across 108 brand entries and 13 price bases, refreshed 08 Sep 2026. Ranges span every Etanercept pack in that market, so a high figure is usually a larger pack rather than the same product.
This table is a regulatory record of where the molecule is listed. The DIN on this page is no longer authorized for sale in Canada, so Nexara does not quote it — see the alternatives above.
Is there a generic Etanercept in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
4 holders have a Canadian DIN containing Etanercept, across 10 DINs, of which 8 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| SANDOZ CANADA INCORPORATED | 3 | 3 | ERELZI | Sourceable in Canada |
| LUPIN PHARMA CANADA LIMITED | 3 | 2 | RYMTI | Sourceable in Canada |
| SAMSUNG BIOEPIS CO., LTD | 2 | 2 | BRENZYS | Sourceable in Canada |
| IMMUNEX CORPORATION | 2 | 1 | ENBREL | Sourceable in Canada |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 1 ML |
|---|---|
| Dosage form | LIQUID ; POWDER FOR SOLUTION ; KIT |
| Route | SUBCUTANEOUS |
| Pack configuration (monograph) | ENBREL single-use prefilled syringes are available in 25 mg* (0.51 mL of a 50 mg/mL solution of etanercept, minimum deliverable volume of 0.47 mL) and 50 mg (0.98 mL of a 50 mg/mL solution of etanercept, minimum deliverable volume of 0.94 mL) dosage strength. ENBREL SureClick® autoinjectors are available in 50 mg (0.98 mL of a 50 mg/mL solution of etanercept, minimum deliverable volume of 0.94 mL) dosage strength. ENBREL 25 mg* and 50 mg single-use prefilled syringes and ENBREL 50 mg single-use prefilled SureClick® autoinjectors are supplied in cartons containing four syringes or autoinjectors with 27-gauge, ½ inch needles. A single syringe or autoinjector replacement carton is available if needed. ENBREL multiple-use vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½ inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. A single dose replacement tray is available, if needed. |
| Storage | null |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Etanercept |
|---|---|
| ATC code | L04AB01 |
| AHFS class | 90:24.16.92 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02242903 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2242903 |
| Brand name | ENBREL |
| Generic / active ingredient | WATER : 1 ML ETANERCEPT : 25 MG |
| Market authorization holder | IMMUNEX CORPORATION |
| Health Canada schedule | Prescription |
| ATC code | L04AB01 |
| ATC anatomical main group | L — Antineoplastic and immunomodulating agents |
| ATC therapeutic subgroup | L04AB |
| Current status | CANCELLED POST MARKET |
| Status date | 31-Jan-2023 |
| Original market date | 2001-03-14 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
8 of 10 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| BRENZYS | 50 MG | SOLUTION | SAMSUNG BIOEPIS CO., LTD | MARKETED | 02455323 |
| BRENZYS | 50 MG | SOLUTION | SAMSUNG BIOEPIS CO., LTD | MARKETED | 02455331 |
| ENBREL | 50 MG | SOLUTION | IMMUNEX CORPORATION | MARKETED | 02274728 |
| ERELZI | 50 MG | SOLUTION | SANDOZ CANADA INCORPORATED | MARKETED | 02462869 |
| ERELZI | 50 MG | SOLUTION | SANDOZ CANADA INCORPORATED | MARKETED | 02462850 |
| ERELZI | 25 MG / 0.5 ML | SOLUTION | SANDOZ CANADA INCORPORATED | MARKETED | 02462877 |
| RYMTI | 50 MG / 1 ML | SOLUTION | LUPIN PHARMA CANADA LIMITED | MARKETED | 02530295 |
| RYMTI | 50 MG / 1 ML | SOLUTION | LUPIN PHARMA CANADA LIMITED | MARKETED | 02530309 |
| RYMTI | 25 MG / 0.5 ML | SOLUTION | LUPIN PHARMA CANADA LIMITED | APPROVED | 02530287 |
2 · Same class — other molecules in ATC L04AB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Adalimumab | ABRILADA · AMGEVITA · HADLIMA · HADLIMA PUSHTOUCH · +6 more | 41 | 34 | Yes |
| Etanercept | BRENZYS · ENBREL · ERELZI · RYMTI | 10 | 8 | Yes |
| Infliximab | AVSOLA · IXIFI · OMVYENCE · REMDANTRY · +4 more | 9 | 6 | Yes |
| Golimumab | LIVMOTY · SIMPONI · SIMPONI I.V. | 9 | 5 | Yes |
| Certolizumab Pegol | CIMZIA | 2 | 2 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC L04A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| L04AX | Azathioprine · Dimethyl Fumarate · Lenalidomide · Methotrexate · Other Immunosuppressants · +3 more | 191 | 124 |
| L04AC | Anakinra · Basiliximab · Bimekizumab · Brodalumab · Canakinumab · +13 more | 85 | 75 |
| L04AA | Abatacept · Alefacept · Antilymphocyte Immunoglobulin (Horse) · Antithymocyte Immunoglobulin (Rabbit) · Apremilast · +4 more | 73 | 42 |
| L04AD | Ciclosporin · Tacrolimus | 49 | 30 |
| L04AK | Leflunomide · Teriflunomide | 44 | 25 |
| L04AH | Everolimus · Sirolimus | 36 | 23 |
| L04AF | Baricitinib · Deucravacitinib · Ritlecitinib · Tofacitinib · Upadacitinib | 23 | 19 |
| L04AG | Alemtuzumab · Anifrolumab · Belimumab · Efalizumab · Inebilizumab · +7 more | 20 | 15 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is ENBREL called?
The same molecule, Etanercept, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Erelzi | Latin | Australia, Bahrain, Czechia, Iceland, Norway, Saudi Arabia |
| Nepexto | Latin | Australia, Bahrain, Czechia, Saudi Arabia |
| Brenzys | Latin | Australia, Saudi Arabia |
| Benepali | Latin | Czechia, Iceland, Norway |
| ENBREL PRO PEDIATRICK� POU�IT� | Latin | Czechia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.