ALKERAN 50 MG
MELPHALAN (MELPHALAN HYDROCHLORIDE) : 50 MG BUFFER SOLUTION : 10 ML · DIN 02087286 · ASPEN PHARMACARE CANADA INC.
Health Canada status: MARKETED
What is ALKERAN?
ALKERAN 50 MG contains MELPHALAN (MELPHALAN HYDROCHLORIDE) : 50 MG BUFFER SOLUTION : 10 ML. It is listed in the Health Canada Drug Product Database under DIN 02087286, held by ASPEN PHARMACARE CANADA INC., supplied as KIT ; POWDER FOR SOLUTION ; SOLUTION for INTRA-ARTERIAL ; INTRAVENOUS administration. Health Canada currently lists it as marketed, status dated 19-Jun-2017. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is ALKERAN used for?
Palliative treatment of multiple myeloma and nonresectable epithelial carcinoma of the ovary. Adjuvant to surgery for malignant melanoma (via isolated limb perfusion).
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
What else is ALKERAN called?
The same molecule, MELPHALAN, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Melphalan Hydrochloride TBM | Latin | Saudi Arabia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
Product details and regulatory record
| DIN | 02087286 |
|---|---|
| Brand name | ALKERAN |
| Generic / active ingredient | MELPHALAN (MELPHALAN HYDROCHLORIDE) : 50 MG BUFFER SOLUTION : 10 ML |
| Manufacturer | ASPEN PHARMACARE CANADA INC. |
| Strength | 50 MG |
| Dosage form | KIT ; POWDER FOR SOLUTION ; SOLUTION |
| Route of administration | INTRA-ARTERIAL ; INTRAVENOUS |
| Schedule | Prescription |
| ATC code | L01AA03 MELPHALAN |
| AHFS class | 10:00.00 |
| Biosimilar | No |
| Health Canada status | MARKETED |
| Status date | 19-Jun-2017 |
| Original market date | 1995-12-31 00:00:00 |
How is this product identified?
Purchase orders, customs paperwork and tender documents each ask for a different identifier, and a DIN written without its leading zeros is the single most common reason an order line fails to match. Every form Nexara accepts for this product is listed here.
| DIN (8-digit, as used in Nexara ordering) | 02087286 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2087286 |
| Brand name | ALKERAN |
| Active ingredient / INN | MELPHALAN (MELPHALAN HYDROCHLORIDE) : 50 MG BUFFER SOLUTION : 10 ML |
| ATC code | L01AA03 |
| ATC anatomical main group | L — Antineoplastic and immunomodulating agents |
| ATC therapeutic subgroup | L01 |
| AHFS class | 10:00.00 |
| Health Canada schedule | Prescription |
| Biosimilar biologic | No |
| Market authorization holder | ASPEN PHARMACARE CANADA INC. |
How is it administered?
Oral: 6 mg daily initially, adjusted based on blood counts. IV: 16 mg/m2 infused over 15-90 mins. Intra-arterial: 1.0-1.5 mg/kg via hyperthermic isolated limb perfusion.
Included because it drives pack selection and wastage. Consult the monograph.
How is it stored and handled?
Injection: Reconstituted solution stable for 2 hours at 30°C; do not refrigerate. Diluted solution (0.1-0.45 mg/mL) stable for 50 mins at 30°C or 3 hours at 20°C.
How is it supplied?
Tablets: Bottles of 50. Injection: 2-component pack (50 mg vial freeze-dried powder and 10 mL vial solvent-diluent).
Which pack is which?
| Strength on the label | 50 MG |
|---|---|
| Dosage form | KIT ; POWDER FOR SOLUTION ; SOLUTION |
| Route | INTRA-ARTERIAL ; INTRAVENOUS |
| Packaging as described in the monograph | Tablets: Bottles of 50. Injection: 2-component pack (50 mg vial freeze-dried powder and 10 mL vial solvent-diluent). |
| Storage | Injection: Reconstituted solution stable for 2 hours at 30°C; do not refrigerate. Diluted solution (0.1-0.45 mg/mL) stable for 50 mins at 30°C or 3 hours at 20°C. |
One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced. Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Cold chain. This product is stored refrigerated. Nexara ships it on a validated cold chain with temperature monitoring; a delivery address that cannot receive and store it at 2–8 °C on arrival must be flagged before the order is placed.
Contraindications
Hypersensitivity to melphalan; prior resistance; cross-sensitivity with chlorambucil; recent radiotherapy or other chemotherapy; depressed neutrophil/platelet counts; breast-feeding.
Warnings and precautions
Serious warnings: Hypersensitivity/anaphylaxis, bone marrow suppression, pulmonary toxicity, infertility, secondary malignancies, mutagenicity, and teratogenicity.
What can be used instead?
Other Canadian products sharing ATC code L01AA03 MELPHALAN. 4 of 8 DINs in this group are currently marketed — marketed products are listed first, because that is what can actually be bought. These tables describe supply, not clinical equivalence: substitution rests with the prescriber or pharmacist, and interchangeability is determined provincially.
| Product | Strength | Form | Manufacturer | Health Canada status | DIN |
|---|---|---|---|---|---|
| ALKERAN | 2 MG | TABLET | ASPEN PHARMACARE CANADA INC. | MARKETED | DIN 00004715 |
| MELPHALAN FOR INJECTION | 50 MG | SOLUTION ; POWDER FOR SOLUTION ; KIT | MARCAN PHARMACEUTICALS INC | MARKETED | DIN 02473348 |
| TARO-MELPHALAN | 10 ML | KIT ; POWDER FOR SOLUTION | TARO PHARMACEUTICALS INC | MARKETED | DIN 02480026 |
| MELPHALAN FOR INJECTION | 10 ML | SOLUTION ; POWDER FOR SOLUTION ; KIT | APOTEX INC | DORMANT | DIN 02468921 |
| MELPHALAN FOR INJECTION | 50 MG | KIT ; POWDER FOR SOLUTION | AURO PHARMA INC | APPROVED | DIN 02508214 |
| MELPHALAN FOR INJECTION | 50 MG | KIT ; POWDER FOR SOLUTION | JUNO PHARMACEUTICALS CORP. | CANCELLED PRE MARKET | DIN 02526077 |
| MELPHALAN FOR INJECTION | 50 MG | KIT ; POWDER FOR SOLUTION | EUGIA PHARMA INC. | APPROVED | DIN 02537389 |
Who else supplies MELPHALAN worldwide?
Nexara tracks national medicine registries and published price lists across multiple markets. MELPHALAN appears in 25 registered pack listings across 9 markets, published on 9 different national price bases. Where a Canadian route is closed, that is where an alternative route of supply starts — subject to the import rules in both countries.
Registered listings are not stock. Ask us to confirm what can actually be sourced for your order.
How much does MELPHALAN cost around the world?
MELPHALAN is listed on 8 national price registers Nexara tracks, across 21 pack listings published on 8 different price bases. What each country publishes is set out below.
| Market | What that country publishes | Brands listed | Pack listings | As of |
|---|---|---|---|---|
| Saudi Arabia | public | 4 | 6 | 01 Sep 2026 |
| Greece | producer price (ex-factory) | 3 | 3 | 03 Sep 2026 |
| Morocco | PPV (public price) | 2 | 3 | 05 Sep 2026 |
| Romania | max producer price | 3 | 3 | 03 Sep 2026 |
| United Kingdom | hospital | 2 | 2 | 31 Aug 2026 |
| Iceland | max wholesale | 1 | 2 | 02 Sep 2026 |
| Australia | ex-manufacturer | 1 | 1 | 08 Sep 2026 |
| South Africa | single exit price | 1 | 1 | 01 Sep 2026 |
Why there are no figures here. These bases are not comparable. A Brazilian ex-factory ceiling, a Belgian pharmacy public price and a Japanese reimbursement rate answer three different questions, and none of them is what a product lands in Canada for. Putting them side by side would mislead in both directions, so Nexara publishes where a molecule is listed and on what basis, and quotes the delivered Canadian price per order.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.