LEDERLE LEUCOVORIN 350MG/VIAL 350 MG — DIN 01927442
LEUCOVORIN (LEUCOVORIN CALCIUM) : 350 MG · LEDERLE CYANAMID CANADA INC. · POWDER FOR SOLUTION · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is LEDERLE LEUCOVORIN 350MG/VIAL?
LEDERLE LEUCOVORIN 350MG/VIAL 350 MG contains LEUCOVORIN (LEUCOVORIN CALCIUM) : 350 MG. It is listed in the Health Canada Drug Product Database under DIN 01927442, held by LEDERLE CYANAMID CANADA INC., supplied as POWDER FOR SOLUTION for INTRAMUSCULAR ; INTRAVENOUS administration. Health Canada currently lists it as cancelled post market, status dated 12-Apr-1999. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
How much does Calcium Folinate cost around the world?
Calcium Folinate is listed on 5 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Austria publishes a KVP (Kassenverkaufspreis); Czechia publishes a max producer price (ex-factory); Saudi Arabia publishes a public. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Czechia | max producer price (ex-factory) | 5 | 16 | CZK███.██ |
| Saudi Arabia | public | 3 | 8 | SAR███.██ |
| United Kingdom | hospital | 6 | 6 | GBP███.██ |
| South Africa | single exit price | 2 | 4 | ZAR███.██ |
| Austria | KVP (Kassenverkaufspreis) | 1 | 1 | EUR███.██ |
35 pack listings across 17 brand entries and 5 price bases, refreshed 03 Sep 2026. Ranges span every Calcium Folinate pack in that market, so a high figure is usually a larger pack rather than the same product.
This table is a regulatory record of where the molecule is listed. The DIN on this page is no longer authorized for sale in Canada, so Nexara does not quote it — see the alternatives above.
Is there a generic Calcium Folinate in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
10 holders have a Canadian DIN containing Calcium Folinate, across 21 DINs, of which 9 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| PFIZER CANADA ULC | 3 | 3 | LEDERLE LEUCOVORIN, LEUCOVORIN CALCIUM INJECTION USP | Sourceable in Canada |
| GENERIC MEDICAL PARTNERS INC | 3 | 2 | LEUCOVORIN CALCIUM INJECTION | Sourceable in Canada |
| JAMP PHARMA CORPORATION | 2 | 1 | JAMP LEUCOVORIN, LEUCOVORIN CALCIUM INJECTION USP | Sourceable in Canada |
| LABORATOIRE RIVA INC. | 1 | 1 | RIVA LEUCOVORIN | Sourceable in Canada |
| MINT PHARMACEUTICALS INC | 1 | 1 | MINT-LEUCOVORIN | Sourceable in Canada |
| TEVA CANADA LIMITED | 1 | 1 | LEUCOVORIN CALCIUM INJECTION | Sourceable in Canada |
| LEDERLE CYANAMID CANADA INC. | 4 | 0 | LEDERLE LEUCOVORIN 350MG/VIAL, LEDERLE LEUCOVORIN 50MG/VIAL, LEDERLE LEUCOVORIN LIQ 10MG/ML, LEUCOVORIN CALCIUM TAB 5MG | No marketed DIN |
| WYETH-AYERST CANADA INC. | 3 | 0 | LEDERLE LEUCOVORIN - LIQ IM IV 10MG/ML, LEDERLE LEUCOVORIN-PWS IM IV 350MG/VIAL, LEDERLE LEUCOVORIN-PWS IM IV 50MG/VIAL | No marketed DIN |
| DAVID BULL LABORATORIES (PTY) LTD. | 2 | 0 | LEUCOVORIN CA INJ (PHARM. BULK VIAL) 10MG/ML, LEUCOVORIN CALCIUM INJ 10MG/ML | No marketed DIN |
| SANDOZ CANADA INCORPORATED | 1 | 0 | LEUCOVORIN CALCIUM INJECTION | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 350 MG |
|---|---|
| Dosage form | POWDER FOR SOLUTION |
| Route | INTRAMUSCULAR ; INTRAVENOUS |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Calcium Folinate |
|---|---|
| ATC code | V03AF03 |
| AHFS class | 91:04.12 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 01927442 |
|---|---|
| DIN (unpadded, as printed on some documents) | 1927442 |
| Brand name | LEDERLE LEUCOVORIN 350MG/VIAL |
| Generic / active ingredient | LEUCOVORIN (LEUCOVORIN CALCIUM) : 350 MG |
| Market authorization holder | LEDERLE CYANAMID CANADA INC. |
| Health Canada schedule | Prescription |
| ATC code | V03AF03 |
| ATC anatomical main group | V — Various |
| ATC therapeutic subgroup | V03AF |
| Current status | CANCELLED POST MARKET |
| Status date | 12-Apr-1999 |
| Original market date | 1991-12-31 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
9 of 21 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| JAMP LEUCOVORIN | 5 MG | TABLET | JAMP PHARMA CORPORATION | MARKETED | 02548208 |
| LEDERLE LEUCOVORIN | 5 MG | TABLET | PFIZER CANADA ULC | MARKETED | 02170493 |
| LEUCOVORIN CALCIUM INJECTION | 1000 MG / 100 ML | SOLUTION | GENERIC MEDICAL PARTNERS INC | MARKETED | 02496925 |
| LEUCOVORIN CALCIUM INJECTION | 10 MG | SOLUTION | TEVA CANADA LIMITED | MARKETED | 02087316 |
| LEUCOVORIN CALCIUM INJECTION | 10 MG | SOLUTION | GENERIC MEDICAL PARTNERS INC | MARKETED | 02480042 |
| LEUCOVORIN CALCIUM INJECTION USP | 10 MG | Solution | PFIZER CANADA ULC | MARKETED | 02183005 |
| LEUCOVORIN CALCIUM INJECTION USP | 10 MG | SOLUTION | PFIZER CANADA ULC | MARKETED | 02182998 |
| MINT-LEUCOVORIN | 5 MG | TABLET | MINT PHARMACEUTICALS INC | MARKETED | 02496828 |
| RIVA LEUCOVORIN | 5 MG | TABLET | LABORATOIRE RIVA INC. | MARKETED | 02493357 |
| LEDERLE LEUCOVORIN - LIQ IM IV 10MG/ML | 10 MG | LIQUID | WYETH-AYERST CANADA INC. | CANCELLED POST MARKET | 02170485 |
2 · Same class — other molecules in ATC V03AF
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Calcium Folinate | JAMP LEUCOVORIN · LEDERLE LEUCOVORIN · LEDERLE LEUCOVORIN - LIQ IM IV 10MG/ML · LEDERLE LEUCOVORIN 350MG/VIAL · +11 more | 21 | 9 | Yes |
| Dexrazoxane | DEXRAZOXANE FOR INJECTION · ZINECARD | 5 | 3 | Yes |
| Mesna | MESNA FOR INJECTION · UROMITEXAN · UROMITEXAN INJ 100MG/ML | 4 | 3 | Yes |
| Rasburicase | FASTURTEC | 2 | 1 | Yes |
| Amifostine | ETHYOL - PWS IV 500MG/VIAL | 1 | 0 | Not in Canada |
| Palifermin | KEPIVANCE | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC V03A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| V03AC | Deferasirox · Deferiprone · Deferoxamine | 57 | 44 |
| V03AN | Carbon Dioxide · Combination · Helium · Medical Air · Medical Gases · +2 more | 112 | 43 |
| V03AB | Amyl Nitrite · Andexanet Alfa · Antidotes · Digitalis Antitoxin · Dimercaprol · +16 more | 87 | 31 |
| V03AE | Calcium Acetate · Drugs For Treatment Of Hyperkalemia And Hyperphosphatemia · Lanthanum Carbonate · Patiromer Calcium · Polystyrene Sulphonate · +3 more | 40 | 19 |
| V03AH | Diazoxide | 2 | 1 |
| V03AX | Cobicistat · Difelikefalin · Other Therapeutic Products | 8 | 1 |
| V03AZ | Ethanol | 1 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is LEDERLE LEUCOVORIN 350MG/VIAL called?
The same molecule, Calcium Folinate, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| CALCIUM FOLINATE KALCEKS | Latin | Czechia |
| Calcium Folinate Hainan | Latin | Saudi Arabia |
| Calcium folinate Kabi | Latin | Czechia, Saudi Arabia |
| CALCIUM FOLINATE SANDOZ | Latin | Czechia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.