ZAROXOLYN TAB 10MG 10 MG — DIN 00888427
METOLAZONE : 10 MG · RHONE-POULENC RORER CANADA INC. · TABLET · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is ZAROXOLYN TAB 10MG?
ZAROXOLYN TAB 10MG 10 MG contains METOLAZONE : 10 MG. It is listed in the Health Canada Drug Product Database under DIN 00888427, held by RHONE-POULENC RORER CANADA INC., supplied as TABLET for ORAL administration. Health Canada currently lists it as cancelled post market, status dated 12-Aug-1998. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
How much does Metolazone cost around the world?
Metolazone is listed on 2 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Italy publishes a prezzo al pubblico (classe A); United States publishes a acquisition. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 3 | 41 | USD███.██ |
| Italy | prezzo al pubblico (classe A) | 2 | 2 | EUR███.██ |
43 pack listings across 5 brand entries and 2 price bases, refreshed 03 Sep 2026. Ranges span every Metolazone pack in that market, so a high figure is usually a larger pack rather than the same product.
This table is a regulatory record of where the molecule is listed. The DIN on this page is no longer authorized for sale in Canada, so Nexara does not quote it — see the alternatives above.
Is there a generic Metolazone in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
3 holders have a Canadian DIN containing Metolazone, across 3 DINs, of which 1 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| SANOFI-AVENTIS CANADA INC | 1 | 1 | ZAROXOLYN | Sourceable in Canada |
| AVENTIS PHARMA INC | 1 | 0 | ZAROXOLYN | No marketed DIN |
| RHONE-POULENC RORER CANADA INC. | 1 | 0 | ZAROXOLYN TAB 10MG | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 10 MG |
|---|---|
| Dosage form | TABLET |
| Route | ORAL |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Metolazone |
|---|---|
| ATC code | C03BA08 |
| AHFS class | 40:28.24 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 00888427 |
|---|---|
| DIN (unpadded, as printed on some documents) | 888427 |
| Brand name | ZAROXOLYN TAB 10MG |
| Generic / active ingredient | METOLAZONE : 10 MG |
| Market authorization holder | RHONE-POULENC RORER CANADA INC. |
| Health Canada schedule | Prescription |
| ATC code | C03BA08 |
| ATC anatomical main group | C — Cardiovascular system |
| ATC therapeutic subgroup | C03BA |
| Current status | CANCELLED POST MARKET |
| Status date | 12-Aug-1998 |
| Original market date | 1974-12-31 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
1 of 3 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| ZAROXOLYN | 2.5 MG | TABLET | SANOFI-AVENTIS CANADA INC | MARKETED | 00888400 |
| ZAROXOLYN | 5 MG | TABLET | AVENTIS PHARMA INC | CANCELLED POST MARKET | 00888419 |
2 · Same class — other molecules in ATC C03BA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Chlortalidone | APO CHLORTHALIDONE TAB 100MG · APO-CHLORTHALIDONE · CHLORTHALIDONE 100MG TABLETS · CHLORTHALIDONE 50MG TABLETS · +9 more | 19 | 7 | Yes |
| Indapamide | APO-INDAPAMIDE 1.25 MG TABLETS · APO-INDAPAMIDE 2.5MG TABLETS · DOM-INDAPAMIDE TABLETS 1.25MG · DOM-INDAPAMIDE TABLETS 2.5MG · +16 more | 28 | 4 | Yes |
| Metolazone | ZAROXOLYN · ZAROXOLYN TAB 10MG | 3 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC C03B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| C03BD | Xanthine Derivatives | 3 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.