PROSTIN VR STERILE SOLUTION 500 MCG — DIN 00559253
ALPROSTADIL : 500 MCG · PFIZER CANADA ULC · SOLUTION · wholesale supply in Canada
Health Canada status: MARKETED
What is PROSTIN VR STERILE SOLUTION?
PROSTIN VR STERILE SOLUTION 500 MCG contains ALPROSTADIL : 500 MCG. It is listed in the Health Canada Drug Product Database under DIN 00559253, held by PFIZER CANADA ULC, supplied as SOLUTION for INTRA-ARTERIAL ; INTRAVENOUS administration. Health Canada currently lists it as marketed, status dated 23-May-2006. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is PROSTIN VR STERILE SOLUTION used for?
Temporarily maintain patency of the ductus arteriosus in neonates with congenital heart defects who depend upon a patent ductus arteriosus for survival until surgery.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Alprostadil cost around the world?
Alprostadil is listed on 15 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Bahrain publishes a retail (max); Brazil publishes a preco fabrica (ex-factory ceiling). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Norway | max AUP (pharmacy retail) | 3 | 7 | NOK███.██ |
| Spain | PVP con IVA (public price) | 6 | 6 | EUR███.██ |
| Greece | producer price (ex-factory) | 3 | 3 | EUR███.██ |
| Italy | ex-factory (classe H) | 3 | 3 | EUR███.██ |
| Romania | max producer price | 3 | 3 | RON███.██ |
| Saudi Arabia | public | 3 | 3 | SAR███.██ |
| Slovakia | categorised final price | 3 | 3 | EUR███.██ |
| Australia | ex-manufacturer | 1 | 2 | AUD███.██ |
| Brazil | preco fabrica (ex-factory ceiling) | 1 | 2 | BRL███.██ |
| Hungary | producer price (ex-factory) | 2 | 2 | HUF███.██ |
| Morocco | PPV (public price) | 1 | 2 | MAD███.██ |
| South Africa | single exit price | 2 | 2 | ZAR███.██ |
| United Arab Emirates | public | 1 | 1 | AED███.██ |
| Bahrain | retail (max) | 1 | 1 | BHD███.██ |
| Iceland | max wholesale | 1 | 1 | ISK███.██ |
| Italy | prezzo al pubblico (classe A) | 1 | 1 | EUR███.██ |
42 pack listings across 35 brand entries and 14 price bases, refreshed 08 Sep 2026. Ranges span every Alprostadil pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Alprostadil in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
3 holders have a Canadian DIN containing Alprostadil, across 3 DINs, of which 1 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| PFIZER CANADA ULC | 1 | 1 | PROSTIN VR STERILE SOLUTION | Sourceable in Canada |
| ADVANCED DOSAGE FORMS INC. | 1 | 0 | ALPROSTADIL INJECTION USP | No marketed DIN |
| NOVOPHARM LIMITED | 1 | 0 | ALPROSTADIL INJECTION, USP | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 500 MCG |
|---|---|
| Dosage form | SOLUTION |
| Route | INTRA-ARTERIAL ; INTRAVENOUS |
| Pack configuration (monograph) | 1 mL colourless glass ampoules, packaged in cartons containing 5 ampoules. |
| Storage | Store in a refrigerator at 2°C to 8°C. Prepare fresh dilutions every 24 hours. |
| Shipping class | Cold chain — validated shipper with temperature monitoring |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Cold chain. This product is stored refrigerated. Nexara ships it on a validated cold chain with temperature monitoring; a delivery address that cannot receive and store it at 2–8 °C on arrival must be flagged before the order is placed.
Substance and classification
| Active substance | Alprostadil |
|---|---|
| ATC code | C01EA01 |
| AHFS class | 24:12.92 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 00559253 |
|---|---|
| DIN (unpadded, as printed on some documents) | 559253 |
| Brand name | PROSTIN VR STERILE SOLUTION |
| Generic / active ingredient | ALPROSTADIL : 500 MCG |
| Market authorization holder | PFIZER CANADA ULC |
| Health Canada schedule | Prescription |
| ATC code | C01EA01 |
| ATC anatomical main group | C — Cardiovascular system |
| ATC therapeutic subgroup | C01EA |
| Current status | MARKETED |
| Status date | 23-May-2006 |
| Original market date | 1982-12-31 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Initial: 0.1 mcg/kg/min via continuous IV (preferred) or umbilical artery catheter. Maintenance: Reduce to lowest effective dose (0.05 to 0.01 mcg/kg/min). Dilute before use.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Cyanotic neonates with persistent fetal circulation; neonates with total anomalous pulmonary venous return below the diaphragm, polysplenia, or asplenia with obstructed pulmonary venous return.
Warnings and precautions
Apnea occurs in 10-12% of neonates (especially <2kg); use only in facilities with intensive care. Monitor for gastric outlet obstruction, cortical proliferation of long bones, and hypotension.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
1 of 3 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| ALPROSTADIL INJECTION USP | 500 MCG | SOLUTION | ADVANCED DOSAGE FORMS INC. | DORMANT | 02285282 |
| ALPROSTADIL INJECTION, USP | 500 MCG | LIQUID | NOVOPHARM LIMITED | CANCELLED POST MARKET | 02241680 |
2 · Same class — other molecules in ATC C01EA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Alprostadil | ALPROSTADIL INJECTION USP · ALPROSTADIL INJECTION, USP · PROSTIN VR STERILE SOLUTION | 3 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC C01E
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| C01EB | Adenosine · Indometacin · Ivabradine · Mavacamten · Ranolazine · +1 more | 102 | 11 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is PROSTIN VR STERILE SOLUTION called?
The same molecule, Alprostadil, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Bondil | Latin | Norway |
| CAVERJECT | Latin | Brazil, Morocco |
| Caverject Impulse | Latin | Australia |
| Prostin VR | Latin | Bahrain, South Africa |
| Prostivas | Latin | Iceland, Norway |
| Vitaros | Latin | Norway |
| Alprostan | Latin | Slovakia |
| Prostavasin | Latin | Slovakia |
| PROSTIN VR AMP | Latin | Saudi Arabia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.