C.E.S. TABLETS 1.25 MG — DIN 00265489
CONJUGATED ESTROGENS : 1.25 MG · VALEANT CANADA LP / VALEANT CANADA S.E.C. · TABLET · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is C.E.S. TABLETS?
C.E.S. TABLETS 1.25 MG contains CONJUGATED ESTROGENS : 1.25 MG. It is listed in the Health Canada Drug Product Database under DIN 00265489, held by VALEANT CANADA LP / VALEANT CANADA S.E.C., supplied as TABLET for ORAL administration. Health Canada currently lists it as cancelled post market, status dated 30-Jul-2014. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
What is C.E.S. TABLETS used for?
C.E.S.® (conjugated estrogens tablets, CSD) is indicated for: Relief of menopausal and postmenopausal symptoms occurring in naturally or surgically induced estrogen deficiency states including vaginal and vulvar atrophy (with or without pruritus). Prevention and treatment of osteoporosis in naturally occurring or surgically induced estrogen-deficiency states. Hypoestrogenism due to hypogonadism, castration, or primary ovarian failure. Atrophic vaginitis. In male patients: Inoperable progressing prostatic cancer (for palliation only when castration is not feasible, or when castration failed or delayed escape following a response to castration occurred).
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Conjugated Estrogens cost around the world?
Conjugated Estrogens is listed on 3 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Iceland publishes a max wholesale; South Africa publishes a single exit price; United States publishes a acquisition. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 4 | 8 | USD███.██ |
| Iceland | max wholesale | 1 | 1 | ISK███.██ |
| South Africa | single exit price | 1 | 1 | ZAR███.██ |
10 pack listings across 6 brand entries and 3 price bases, refreshed 03 Sep 2026. Ranges span every Conjugated Estrogens pack in that market, so a high figure is usually a larger pack rather than the same product.
This table is a regulatory record of where the molecule is listed. The DIN on this page is no longer authorized for sale in Canada, so Nexara does not quote it — see the alternatives above.
Is there a generic Conjugated Estrogens in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
9 holders have a Canadian DIN containing Conjugated Estrogens, across 33 DINs, of which 4 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| PFIZER CANADA ULC | 7 | 4 | PREMARIN, PREMARIN INTRAVENOUS, PREMARIN VAGINAL CREAM | Sourceable in Canada |
| AYERST LABORATORIES | 6 | 0 | PREMARIN CRM 0.625MG/GM, PREMARIN INJ 25MG/5ML, PREMARIN TABLETS 0.3MG, PREMARIN TABLETS 0.625MG, PREMARIN TABLETS 1.25MG, +1 more | No marketed DIN |
| APOTEX INC | 5 | 0 | APO-CONEST TAB 0.3MG, APO-CONEST TAB 0.625MG, APO-CONEST TAB 0.9MG, APO-CONEST TAB 1.25MG, APO-CONEST TAB 2.5MG | No marketed DIN |
| LABORATOIRE RIVA INC. | 5 | 0 | CONGEST | No marketed DIN |
| PHARMASCIENCE INC | 4 | 0 | PMS-CONJUGATED ESTROGENS C.S.D. | No marketed DIN |
| VALEANT CANADA LP / VALEANT CANADA S.E.C. | 3 | 0 | C.E.S. TABLETS | No marketed DIN |
| BAUSCH HEALTH, CANADA INC. | 1 | 0 | C.E.S. | No marketed DIN |
| WYETH CANADA | 1 | 0 | PREMARIN TABLETS 0.9MG | No marketed DIN |
| WYETH-AYERST CANADA INC. | 1 | 0 | PREMARIN TABLETS 2.5MG | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 1.25 MG |
|---|---|
| Dosage form | TABLET |
| Route | ORAL |
| Pack configuration (monograph) | null |
| Storage | STORAGE AND STABILITY. SPECIAL HANDLING INSTRUCTIONS |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Conjugated Estrogens |
|---|---|
| ATC code | G03CA57 |
| AHFS class | 68:16.04 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 00265489 |
|---|---|
| DIN (unpadded, as printed on some documents) | 265489 |
| Brand name | C.E.S. TABLETS |
| Generic / active ingredient | CONJUGATED ESTROGENS : 1.25 MG |
| Market authorization holder | VALEANT CANADA LP / VALEANT CANADA S.E.C. |
| Health Canada schedule | Prescription |
| ATC code | G03CA57 |
| ATC anatomical main group | G — Genito-urinary system and sex hormones |
| ATC therapeutic subgroup | G03CA |
| Current status | CANCELLED POST MARKET |
| Status date | 30-Jul-2014 |
| Original market date | 1963-12-31 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
4 of 33 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| PREMARIN | 0.3 MG | TABLET (EXTENDED-RELEASE) | PFIZER CANADA ULC | MARKETED | 02414678 |
| PREMARIN | 1.25 MG | TABLET (EXTENDED-RELEASE) | PFIZER CANADA ULC | MARKETED | 02414694 |
| PREMARIN INTRAVENOUS | 25 MG | POWDER FOR SOLUTION | PFIZER CANADA ULC | MARKETED | 02043386 |
| PREMARIN VAGINAL CREAM | 0.625 MG | Cream | PFIZER CANADA ULC | MARKETED | 02043440 |
| APO-CONEST TAB 0.3MG | 0.3 MG | TABLET | APOTEX INC | CANCELLED POST MARKET | 00798231 |
| APO-CONEST TAB 0.625MG | 0.625 MG | TABLET | APOTEX INC | CANCELLED POST MARKET | 00798223 |
| APO-CONEST TAB 0.9MG | 0.9 MG | TABLET | APOTEX INC | CANCELLED POST MARKET | 00798215 |
| APO-CONEST TAB 1.25MG | 1.25 MG | TABLET | APOTEX INC | CANCELLED POST MARKET | 00798207 |
| APO-CONEST TAB 2.5MG | 2.5 MG | TABLET | APOTEX INC | CANCELLED POST MARKET | 00798193 |
| C.E.S. | 0.625 MG | TABLET | BAUSCH HEALTH, CANADA INC. | DORMANT | 00265470 |
2 · Same class — other molecules in ATC G03CA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Estradiol | CLIMARA 100 · CLIMARA 25 · CLIMARA 50 · CLIMARA 75 · +31 more | 51 | 22 | Yes |
| Conjugated Estrogens | APO-CONEST TAB 0.3MG · APO-CONEST TAB 0.625MG · APO-CONEST TAB 0.9MG · APO-CONEST TAB 1.25MG · +15 more | 33 | 4 | Yes |
| Estrone | ESTRAGYN VAGINAL CREAM · OESTRILIN CONES VAGINAUX · OESTRILIN CREME VAGINALE 1MG · OGEN .625 · +2 more | 6 | 1 | Yes |
| Ethinylestradiol | ESTINYL TAB 0.05MG · ESTINYL TAB 0.5MG · ESTINYL TABLETS 0.02 MG. | 3 | 0 | Not in Canada |
| Natural And Semisynthetic Estrogens, Plain | ESTRAGYN · NEO ESTRONE TAB 1.25MG | 3 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC G03C
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| G03CC | Conjugated Estrogens And Bazedoxifene | 1 | 1 |
| G03CX | Tibolone | 1 | 1 |
| G03CB | Dienestrol · Diethylstilbestrol | 4 | 0 |
4 · Fixed-dose combinations with Canadian supply
| Product | Active ingredients | Holder | Status | DIN |
|---|---|---|---|---|
| DUAVIVE | CONJUGATED ESTROGENS 0.45 MG; BAZEDOXIFENE (BAZEDOXIFENE ACETATE) 20 MG | PFIZER CANADA ULC | MARKETED | 02432854 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is C.E.S. TABLETS called?
The same molecule, Conjugated Estrogens, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Conjugated Oestrogen | Latin | Iceland |
| Estracombi TTS | Latin | South Africa |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.