METHOPRAZINE 50 MG — DIN 02238406
METHOTRIMEPRAZINE (METHOTRIMEPRAZINE MALEATE) : 50 MG · AA PHARMA INC · TABLET · wholesale supply in Canada
Health Canada status: MARKETED
What is METHOPRAZINE?
METHOPRAZINE 50 MG contains METHOTRIMEPRAZINE (METHOTRIMEPRAZINE MALEATE) : 50 MG. It is listed in the Health Canada Drug Product Database under DIN 02238406, held by AA PHARMA INC, supplied as TABLET for ORAL administration. Health Canada currently lists it as marketed, status dated 23-Apr-2014. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is METHOPRAZINE used for?
METHOPRAZINE (Methotrimeprazine Maleate Tablets) is indicated for: Psychotic disturbances: acute and chronic schizophrenias, senile psychoses, manic-depressive syndromes. Analgesic: In pain due to cancer, zona, trigeminal neuralgia, neurocostal neuralgia, in phantom limb pains, muscular discomforts and as post-operative analgesic adjunct. Anti-emetic: For the treatment of nausea and vomiting of central origin. Sedative: For the management of insomnia.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Levomepromazine cost around the world?
Levomepromazine is listed on 3 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Greece publishes a producer price (ex-factory); Morocco publishes a PPV (public price); United Kingdom publishes a hospital. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United Kingdom | hospital | 5 | 5 | GBP███.██ |
| Morocco | PPV (public price) | 1 | 4 | MAD███.██ |
| Greece | producer price (ex-factory) | 1 | 1 | EUR███.██ |
10 pack listings across 7 brand entries and 3 price bases, refreshed 05 Sep 2026. Ranges span every Levomepromazine pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Levomepromazine in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
8 holders have a Canadian DIN containing Levomepromazine, across 24 DINs, of which 5 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| AA PHARMA INC | 4 | 4 | METHOPRAZINE | Sourceable in Canada |
| NEURAXPHARM ARZNEIMITTEL GMBH | 1 | 1 | NOZINAN | Sourceable in Canada |
| PRO DOC LIMITEE | 4 | 0 | METHOTRIMEPRAZINE-2, METHOTRIMEPRAZINE-25, METHOTRIMEPRAZINE-5, METHOTRIMEPRAZINE-50 | No marketed DIN |
| SANOFI-AVENTIS CANADA INC | 4 | 0 | NOZINAN | No marketed DIN |
| LABORATOIRE RIVA INC. | 3 | 0 | RIVA-MEPRAZINE 25MG TABLETS, RIVA-MEPRAZINE 50MG TABLETS, RIVA-MEPRAZINE 5MG TABLETS | No marketed DIN |
| NOVOPHARM LIMITED | 3 | 0 | NOV MEPRAZINE TAB 50MG, NOVO MEPRAZINE TAB 25MG, NOVO MEPRAZINE TAB 5MG | No marketed DIN |
| PHARMASCIENCE INC | 3 | 0 | PMS-METHOTRIMEPRAZINE | No marketed DIN |
| AVENTIS PHARMA INC | 2 | 0 | NOZINAN | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 50 MG |
|---|---|
| Dosage form | TABLET |
| Route | ORAL |
| Pack configuration (monograph) | Bottles of 100 and 500 tablets (for 2 mg, 5 mg, 25 mg, and 50 mg strengths) |
| Storage | null |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Levomepromazine |
|---|---|
| ATC code | N05AA02 |
| AHFS class | 28:16.08.24 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02238406 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2238406 |
| Brand name | METHOPRAZINE |
| Generic / active ingredient | METHOTRIMEPRAZINE (METHOTRIMEPRAZINE MALEATE) : 50 MG |
| Market authorization holder | AA PHARMA INC |
| Health Canada schedule | Prescription |
| ATC code | N05AA02 |
| ATC anatomical main group | N — Nervous system |
| ATC therapeutic subgroup | N05AA |
| Current status | MARKETED |
| Status date | 23-Apr-2014 |
| Original market date | 1998-07-20 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Adults: 6-25 mg/day (minor) or 50-75 mg/day (severe) in divided doses. Pediatrics (1-18y): 0.25 mg/kg daily. Adjust based on individual needs. Gradual withdrawal is advised.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Children <1 year; hypersensitivity to phenothiazines; coma/CNS depression; concomitant dopaminergics; blood dyscrasia; bone marrow depression; hepatic impairment; brain damage; pheochromocytoma.
Warnings and precautions
Increased mortality in elderly with dementia; Neuroleptic Malignant Syndrome (NMS); QT interval prolongation; orthostatic hypotension; venous thromboembolism; seizure threshold lowering.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
5 of 24 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| METHOPRAZINE | 2 MG | TABLET | AA PHARMA INC | MARKETED | 02238403 |
| METHOPRAZINE | 25 MG | TABLET | AA PHARMA INC | MARKETED | 02238405 |
| METHOPRAZINE | 5 MG | TABLET | AA PHARMA INC | MARKETED | 02238404 |
| NOZINAN | 25 MG | SOLUTION | NEURAXPHARM ARZNEIMITTEL GMBH | MARKETED | 01927698 |
| METHOTRIMEPRAZINE-2 | 2 MG | TABLET | PRO DOC LIMITEE | CANCELLED POST MARKET | 02239632 |
| METHOTRIMEPRAZINE-25 | 25 MG | TABLET | PRO DOC LIMITEE | CANCELLED POST MARKET | 02239634 |
| METHOTRIMEPRAZINE-5 | 5 MG | TABLET | PRO DOC LIMITEE | CANCELLED POST MARKET | 02239633 |
| METHOTRIMEPRAZINE-50 | 50 MG | TABLET | PRO DOC LIMITEE | CANCELLED POST MARKET | 02239635 |
| NOV MEPRAZINE TAB 50MG | 50 MG | TABLET | NOVOPHARM LIMITED | CANCELLED POST MARKET | 01964933 |
| NOVO MEPRAZINE TAB 25MG | 25 MG | TABLET | NOVOPHARM LIMITED | CANCELLED POST MARKET | 01964925 |
2 · Same class — other molecules in ATC N05AA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Levomepromazine | METHOPRAZINE · METHOTRIMEPRAZINE-2 · METHOTRIMEPRAZINE-25 · METHOTRIMEPRAZINE-5 · +9 more | 24 | 5 | Yes |
| Chlorpromazine | APO CHLORPROMAZINE · CHLORPROM TAB 100MG · CHLORPROM TAB 25MG · CHLORPROM TAB 50MG · +18 more | 26 | 3 | Yes |
| Promazine | PROMAZINE HCL INJ 50MG/ML | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC N05A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| N05AH | Asenapine · Clozapine · Loxapine · Olanzapine · Quetiapine | 589 | 220 |
| N05AX | Aripiprazole · Brexpiprazole · Cariprazine · Paliperidone · Risperidone | 352 | 175 |
| N05AE | Lurasidone · Ziprasidone | 60 | 41 |
| N05AB | Fluphenazine · Perphenazine · Prochlorperazine · Thioproperazine · Trifluoperazine | 104 | 10 |
| N05AD | Droperidol · Haloperidol | 53 | 9 |
| N05AF | Flupentixol · Tiotixene · Zuclopenthixol | 25 | 8 |
| N05AN | Lithium | 26 | 7 |
| N05AC | Mesoridazine · Periciazine · Pipotiazine · Thioridazine | 32 | 3 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is METHOPRAZINE called?
The same molecule, Levomepromazine, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| NOZINAN | Latin | Morocco |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.