INDOCYANINE GREEN FOR INJECTION, USP 25 MG — DIN 02485796
INDOCYANINE GREEN : 25 MG · DIAGNOSTIC GREEN LIMITED · POWDER FOR SOLUTION · wholesale supply in Canada
Health Canada status: MARKETED
What is INDOCYANINE GREEN FOR INJECTION, USP?
INDOCYANINE GREEN FOR INJECTION, USP 25 MG contains INDOCYANINE GREEN : 25 MG. It is listed in the Health Canada Drug Product Database under DIN 02485796, held by DIAGNOSTIC GREEN LIMITED, supplied as POWDER FOR SOLUTION for INTRAVENOUS administration. Health Canada currently lists it as marketed, status dated 11-Jun-2019. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is INDOCYANINE GREEN FOR INJECTION, USP used for?
Indocyanine Green for Injection, USP is indicated for: determining cardiac output, hepatic function and liver blood flow, and ophthalmic angiography.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Indocyanine Green cost around the world?
Indocyanine Green is listed on 2 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Iceland publishes a max wholesale; Saudi Arabia publishes a public. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Iceland | max wholesale | 1 | 2 | ISK███.██ |
| Saudi Arabia | public | 1 | 1 | SAR███.██ |
3 pack listings across 2 brand entries and 2 price bases, refreshed 02 Sep 2026. Ranges span every Indocyanine Green pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Indocyanine Green in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
2 holders have a Canadian DIN containing Indocyanine Green, across 9 DINs, of which 7 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| NOVADAQ TECHNOLOGIES ULC | 6 | 6 | SPY AGENT GREEN, SPY AGENT GREEN KIT FOR ADVANCED IMAGING MODALITY (AIM) AND PINPOINT, SPY AGENT GREEN KIT FOR SPY ELITE, SPY AGENT GREEN KIT FOR SPY-PHI, SPY AGENT GREEN LYMPHATICS KIT FOR ADVANCED IMAGING MODALITY (AIM) AND PINPOINT | Sourceable in Canada |
| DIAGNOSTIC GREEN LIMITED | 3 | 1 | INDOCYANINE GREEN FOR INJECTION KIT, INDOCYANINE GREEN FOR INJECTION, USP | Sourceable in Canada |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 25 MG |
|---|---|
| Dosage form | POWDER FOR SOLUTION |
| Route | INTRAVENOUS |
| Pack configuration (monograph) | Indocyanine Green for Injection, USP is supplied as: a kit containing six 25 mg Indocyanine Green for Injection, USP vials (25 mg fill in 25 mL vial) and six 10 mL Sterile Water for Injection, USP vials (10 mL fill in 10 mL vial); a carton containing six 25 mg Indocyanine Green for Injection, USP vials only (25 mg fill in 25 mL vial) to be used with Sterile Water for Injection. |
| Storage | Store at 15° to 25°C. Keep out of reach and sight of children. Indocyanine Green for Injection, USP is unstable in aqueous solution and must be used within 6 hours after it is prepared. |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Indocyanine Green |
|---|---|
| ATC code | V04CX01 |
| AHFS class | 36:44.00 ; 36:18.00 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02485796 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2485796 |
| Brand name | INDOCYANINE GREEN FOR INJECTION, USP |
| Generic / active ingredient | INDOCYANINE GREEN : 25 MG |
| Market authorization holder | DIAGNOSTIC GREEN LIMITED |
| Health Canada schedule | Ethical |
| ATC code | V04CX01 |
| ATC anatomical main group | V — Various |
| ATC therapeutic subgroup | V04CX |
| Current status | MARKETED |
| Status date | 11-Jun-2019 |
| Original market date | 2019-06-11 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
The powder should be dissolved with Sterile Water for Injection, USP, and the solution used within 6 hours after it is prepared. Do not use product if mixture shows haziness, particulate matter, discolouration, or leakage. For indicator-dilution studies, the usual doses are: Adults - 5.0 mg, Children - 2.5 mg, Infants - 1.25 mg. These doses are usually injected in 1 mL volume. The total dose of dye injected should be kept below 2 mg/kg. For hepatic function studies, the dosage is calculated on the basis of 0.5 mg/kg of body weight. Exactly 5 mL of Sterile Water for Injection, USP should be added to the 25 mg vial giving 5 mg of dye per mL of solution. Inject the calculated amount of dye (0.5 mg/kg of body weight) into the lumen of an arm vein as rapidly as possible. For ophthalmic angiography studies, dosages up to 40 mg Indocyanine Green for Injection, USP dye in 2 mL of Sterile Water for Injection, USP should be used, depending on the imaging equipment and technique used. The antecubital vein can be injected with an Indocyanine Green for Injection, USP dye bolus and should immediately be followed by a 5 mL bolus of normal saline.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Indocyanine Green for Injection, USP is contraindicated in patients who are hypersensitive to this drug or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container. It contains sodium iodide and should be used with caution in patients who have a history of allergy to iodides because of the risk of anaphylaxis.
Warnings and precautions
Deaths from anaphylaxis have been reported following Indocyanine Green for Injection, USP administration during cardiac catheterization. Indocyanine Green for Injection, USP is unstable in aqueous solution and must be used within 6 hours. If a precipitate is present, discard the solution. Radioactive iodine uptake studies should not be performed for at least a week following the use of Indocyanine Green for Injection, USP. Animal reproduction studies have not been conducted. It is not known whether Indocyanine Green for Injection, USP can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Indocyanine Green for Injection, USP should be given to a pregnant woman only if clearly indicated. It is not known whether this drug is excreted in human milk. Caution should be exercised when Indocyanine Green for Injection, USP is administered to a nursing woman.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
7 of 9 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| SPY AGENT GREEN | 25 MG | POWDER FOR SOLUTION | NOVADAQ TECHNOLOGIES ULC | MARKETED | 02483653 |
| SPY AGENT GREEN KIT FOR ADVANCED IMAGING MODALITY (AIM) AND PINPOINT | 25 MG | POWDER FOR SOLUTION ; KIT | NOVADAQ TECHNOLOGIES ULC | MARKETED | 02483688 |
| SPY AGENT GREEN KIT FOR ADVANCED IMAGING MODALITY (AIM) AND PINPOINT | 25 MG | POWDER FOR SOLUTION ; KIT | NOVADAQ TECHNOLOGIES ULC | MARKETED | 02527839 |
| SPY AGENT GREEN KIT FOR SPY ELITE | 25 MG | KIT ; POWDER FOR SOLUTION | NOVADAQ TECHNOLOGIES ULC | MARKETED | 02483661 |
| SPY AGENT GREEN KIT FOR SPY-PHI | 25 MG | KIT ; POWDER FOR SOLUTION | NOVADAQ TECHNOLOGIES ULC | MARKETED | 02498677 |
| SPY AGENT GREEN LYMPHATICS KIT FOR ADVANCED IMAGING MODALITY (AIM) AND PINPOINT | 25 MG | POWDER FOR SOLUTION ; KIT | NOVADAQ TECHNOLOGIES ULC | MARKETED | 02483696 |
| INDOCYANINE GREEN FOR INJECTION KIT | 25 MG | POWDER FOR SOLUTION ; KIT | DIAGNOSTIC GREEN LIMITED | CANCELLED PRE MARKET | 02485818 |
| INDOCYANINE GREEN FOR INJECTION KIT | 25 MG | KIT ; POWDER FOR SOLUTION | DIAGNOSTIC GREEN LIMITED | CANCELLED POST MARKET | 02485826 |
2 · Same class — other molecules in ATC V04CX
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Other Diagnostic Agents | ARIDOL · CYSVIEW · DENTI-CARE DISCLOSING SOLUTION · ENLON 10MG/ML · +29 more | 50 | 9 | Yes |
| Indocyanine Green | INDOCYANINE GREEN FOR INJECTION KIT · INDOCYANINE GREEN FOR INJECTION, USP · SPY AGENT GREEN · SPY AGENT GREEN KIT FOR ADVANCED IMAGING MODALITY (AIM) AND PINPOINT · +3 more | 9 | 7 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC V04C
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| V04CL | Tests For Allergic Diseases | 10 | 8 |
| V04CC | Sincalide | 3 | 2 |
| V04CD | Tests For Pituitary Function | 1 | 1 |
| V04CF | Tuberculin | 5 | 1 |
| V04CG | Histamine · Methylthionine · Pentagastrin | 5 | 1 |
| V04C | Other Diagnostic Agents | 1 | 0 |
| V04CM | Gonadorelin | 5 | 0 |
| V04CA | Glucose | 6 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is INDOCYANINE GREEN FOR INJECTION, USP called?
Also recorded in Canada as: INDOCYANINE GREEN (US), INDOCYANINE GREEN AND WATER (US), IC-Green (US), SpyAgent (US), Verdye (EU), Pulsion (EU), Diagnogreen (JP), Indocyanine Green (GLOBAL), Indocyanine Green (UK), Indocyanine Green LNP (IN), Dongkook Indocyanine Green (KR), Infracyanine (EU).
The same molecule, Indocyanine Green, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Infracyanine | Latin | Iceland |
| Verdye | Latin | Saudi Arabia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.