NOXIVENT 100 PPM — DIN 02451417
NITRIC OXIDE : 100 PPM · PRAXAIR CANADA INC · GAS · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is NOXIVENT?
NOXIVENT 100 PPM contains NITRIC OXIDE : 100 PPM. It is listed in the Health Canada Drug Product Database under DIN 02451417, held by PRAXAIR CANADA INC, supplied as GAS for INHALATION administration. Health Canada currently lists it as cancelled post market, status dated 28-Jun-2024. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
What is NOXIVENT used for?
Treatment of term and late pre-term (>34 weeks) neonates with hypoxic respiratory failure associated with pulmonary hypertension, to improve oxygenation and reduce the need for ECMO.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
Is there a generic Nitric Oxide in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
3 holders have a Canadian DIN containing Nitric Oxide, across 6 DINs, of which 2 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| AIRGAS THERAPEUTICS LLC | 2 | 1 | KINOX | Sourceable in Canada |
| INO THERAPEUTICS | 2 | 1 | INOMAX | Sourceable in Canada |
| PRAXAIR CANADA INC | 2 | 0 | NOXIVENT | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 100 PPM |
|---|---|
| Dosage form | GAS |
| Route | INHALATION |
| Pack configuration (monograph) | Aluminum cylinders (implied by medical gas status and 100 ppm/800 ppm concentrations). |
| Storage | Store as a compressed medical gas. (Specific temperature range not provided in text, but standard gas handling applies). |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Nitric Oxide |
|---|---|
| ATC code | R07AX01 |
| AHFS class | 24:12.08 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02451417 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2451417 |
| Brand name | NOXIVENT |
| Generic / active ingredient | NITRIC OXIDE : 100 PPM |
| Market authorization holder | PRAXAIR CANADA INC |
| Health Canada schedule | Prescription |
| ATC code | R07AX01 |
| ATC anatomical main group | R — Respiratory system |
| ATC therapeutic subgroup | R07AX |
| Current status | CANCELLED POST MARKET |
| Status date | 28-Jun-2024 |
| Original market date | 2016-03-10 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Administered via inhalation using a calibrated delivery system. Recommended dose is 20 ppm. Weaning should be gradual to avoid rebound pulmonary hypertension.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Neonates dependent on right-to-left shunting. Potential to decrease right-to-left blood flow, which is potentially fatal.
Warnings and precautions
Risk of rebound pulmonary hypertension upon abrupt discontinuation. Monitor methemoglobinemia and NO2 levels. May aggravate cardiac insufficiency in left-to-right shunting.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
2 of 6 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| INOMAX | 800 PPM | GAS | INO THERAPEUTICS | MARKETED | 02270846 |
| KINOX | 800 PPM | GAS | AIRGAS THERAPEUTICS LLC | MARKETED | 02451328 |
| INOMAX | 100 PPM | GAS | INO THERAPEUTICS | CANCELLED POST MARKET | 02270838 |
| KINOX | 100 PPM | GAS | AIRGAS THERAPEUTICS LLC | DORMANT | 02451301 |
| NOXIVENT | 800 PPM | GAS | PRAXAIR CANADA INC | CANCELLED POST MARKET | 02451425 |
2 · Same class — other molecules in ATC R07AX
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Ivacaftor | KALYDECO | 5 | 5 | Yes |
| Ivacaftor And Lumacaftor | ORKAMBI | 5 | 5 | Yes |
| Ivacaftor, Tezacaftor And Elexacaftor | TRIKAFTA | 4 | 4 | Yes |
| Nitric Oxide | INOMAX · KINOX · NOXIVENT | 6 | 2 | Yes |
| Other Respiratory System Products | ALYFTREK · STERILE WATER FOR INHALATION USP | 3 | 2 | Yes |
| Ivacaftor And Tezacaftor | SYMDEKO | 1 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC R07A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| R07AA | Colfosceril Palmitate · Natural Phospholipids | 6 | 3 |
| R07AB | Doxapram | 2 | 0 |
4 · Fixed-dose combinations with Canadian supply
| Product | Active ingredients | Holder | Status | DIN |
|---|---|---|---|---|
| BLES | PHOSPHOLIPID : 27 MG SURFACTANT-ASSOCIATED PROTEINS SP-B AND SP-C : 500 MCG | BLES BIOCHEMICALS INC | MARKETED | 02245464 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.