FIRAZYR 10 MG — DIN 02425696
ICATIBANT (ICATIBANT ACETATE) : 10 MG · TAKEDA CANADA INC · SOLUTION · wholesale supply in Canada
Health Canada status: MARKETED
What is FIRAZYR?
FIRAZYR 10 MG contains ICATIBANT (ICATIBANT ACETATE) : 10 MG. It is listed in the Health Canada Drug Product Database under DIN 02425696, held by TAKEDA CANADA INC, supplied as SOLUTION for SUBCUTANEOUS administration. Health Canada currently lists it as marketed, status dated 21-Jul-2021. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is FIRAZYR used for?
Treatment of acute attacks of hereditary angioedema (HAE) in adults, adolescents and children aged 2 years and older with C1-esterase inhibitor deficiency. (Max 200 chars)
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Icatibant cost around the world?
Icatibant is listed on 14 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Bahrain publishes a retail (max). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Italy | ex-factory (classe H) | 6 | 8 | EUR███.██ |
| Romania | max producer price | 4 | 6 | RON███.██ |
| Czechia | max producer price (ex-factory) | 4 | 4 | CZK███.██ |
| Austria | KVP (Kassenverkaufspreis) | 3 | 3 | EUR███.██ |
| Australia | ex-manufacturer | 3 | 3 | AUD███.██ |
| Hungary | producer price (ex-factory) | 3 | 3 | HUF███.██ |
| Greece | producer price (ex-factory) | 2 | 2 | EUR███.██ |
| Iceland | max wholesale | 2 | 2 | ISK███.██ |
| United Arab Emirates | public | 1 | 1 | AED███.██ |
| Bahrain | retail (max) | 1 | 1 | BHD███.██ |
| United Kingdom | hospital | 1 | 1 | GBP███.██ |
| Luxembourg | reimbursement | 1 | 1 | EUR███.██ |
| Saudi Arabia | public | 1 | 1 | SAR███.██ |
| South Africa | single exit price | 1 | 1 | ZAR███.██ |
37 pack listings across 33 brand entries and 12 price bases, refreshed 08 Sep 2026. Ranges span every Icatibant pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Icatibant in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
6 holders have a Canadian DIN containing Icatibant, across 6 DINs, of which 2 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| JAMP PHARMA CORPORATION | 1 | 1 | ICATIBANT INJECTION | Sourceable in Canada |
| TAKEDA CANADA INC | 1 | 1 | FIRAZYR | Sourceable in Canada |
| ACCORD HEALTHCARE INC | 1 | 0 | ICATIBANT INJECTION | No marketed DIN |
| JUNO PHARMACEUTICALS CORP. | 1 | 0 | ICATIBANT INJECTION | No marketed DIN |
| MINT PHARMACEUTICALS INC | 1 | 0 | MINT-ICATIBANT | No marketed DIN |
| TEVA CANADA LIMITED | 1 | 0 | TEVA-ICATIBANT | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 10 MG |
|---|---|
| Dosage form | SOLUTION |
| Route | SUBCUTANEOUS |
| Pack configuration (monograph) | Carton includes one 3 mL glass prefilled syringe with a 25 G needle. Patient self-administration kits available through OnePath program. |
| Storage | Not explicitly detailed in provided text (section 11 header present but content truncated), though typically room temperature for this product. |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Icatibant |
|---|---|
| ATC code | B06AC02 |
| AHFS class | 92:32.00 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02425696 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2425696 |
| Brand name | FIRAZYR |
| Generic / active ingredient | ICATIBANT (ICATIBANT ACETATE) : 10 MG |
| Market authorization holder | TAKEDA CANADA INC |
| Health Canada schedule | Prescription |
| ATC code | B06AC02 |
| ATC anatomical main group | B — Blood and blood-forming organs |
| ATC therapeutic subgroup | B06AC |
| Current status | MARKETED |
| Status date | 21-Jul-2021 |
| Original market date | 2014-07-14 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Adults: 30 mg SC; max 3 doses/24h. Pediatrics (2-17y): Weight-based dosing (10-30 mg). Administer by slow SC injection in the abdominal area over at least 30 seconds.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity to icatibant or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container.
Warnings and precautions
Laryngeal attacks require immediate medical attention. May aggravate cardiac ischemia. Caution against driving/operating machinery if fatigue or dizziness occurs.
Is Icatibant in shortage in Canada?
A Canadian shortage report is on file for a product containing this molecule: Resolved — reported by JAMP PHARMA CORPORATION, last seen 04 Sep 2026. A shortage on one presentation does not always affect every DIN of the molecule — the alternatives below list what else is marketed in Canada. Nexara can confirm current availability and identify substitutions or import options where permitted.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
2 of 6 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| ICATIBANT INJECTION | 10 MG | SOLUTION | JAMP PHARMA CORPORATION | MARKETED | 02547562 |
| ICATIBANT INJECTION | 30 MG / 3 ML | SOLUTION | ACCORD HEALTHCARE INC | CANCELLED PRE MARKET | 02516608 |
| ICATIBANT INJECTION | 10 MG | SOLUTION | JUNO PHARMACEUTICALS CORP. | CANCELLED PRE MARKET | 02523337 |
| MINT-ICATIBANT | 10 MG | SOLUTION | MINT PHARMACEUTICALS INC | APPROVED | 02524619 |
| TEVA-ICATIBANT | 10 MG | SOLUTION | TEVA CANADA LIMITED | CANCELLED PRE MARKET | 02513773 |
2 · Same class — other molecules in ATC B06AC
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| C1-Inhibitor, Plasma Derived | BERINERT 1500 · BERINERT 500 · CINRYZE · HAEGARDA | 5 | 4 | Yes |
| Icatibant | FIRAZYR · ICATIBANT INJECTION · MINT-ICATIBANT · TEVA-ICATIBANT | 6 | 2 | Yes |
| Lanadelumab | TAKHZYRO | 2 | 2 | Yes |
| Garadacimab | ANDEMBRY | 2 | 1 | Yes |
| Berotralstat | ORLADEYO | 1 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC B06A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| B06AB | Hematin | 1 | 1 |
| B06AA | Bromelains · Hyaluronidase | 13 | 0 |
| B06AX | Exagamglogene Autotemcel | 1 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is FIRAZYR called?
The same molecule, Icatibant, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Cipla Icatibant | Latin | Australia |
| Fyzant | Latin | Australia |
| ICATIBANT ACCORD | Latin | Czechia |
| ICATIBANT FRESENIUS | Latin | Czechia |
| Icatibant Lupin | Latin | Australia |
| Icatibant STADA | Latin | Iceland |
| ICATIBANT ZENTIVA | Latin | Czechia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.