BUPIVACAINE HCL 0.5% AND EPINEPHRINE 1:200,000 INJECTION 5 MG — DIN 02381850
BUPIVACAINE HYDROCHLORIDE : 5 MG EPINEPHRINE BITARTRATE : 0.0091 MG · NOVOCOL PHARMACEUTICAL OF CANADA INC · SOLUTION · wholesale supply in Canada
Health Canada status: DORMANT
What is BUPIVACAINE HCL 0.5% AND EPINEPHRINE 1:200,000 INJECTION?
BUPIVACAINE HCL 0.5% AND EPINEPHRINE 1:200,000 INJECTION 5 MG contains BUPIVACAINE HYDROCHLORIDE : 5 MG EPINEPHRINE BITARTRATE : 0.0091 MG. It is listed in the Health Canada Drug Product Database under DIN 02381850, held by NOVOCOL PHARMACEUTICAL OF CANADA INC, supplied as SOLUTION for BLOCK/INFILTRATION administration. Health Canada currently lists it as dormant, status dated 16-Jul-2026. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A). This DIN is not currently being marketed in Canada, so it is sourced to order where a compliant route exists rather than held in stock.
Is there a generic Bupivacaine, Combinations in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
8 holders have a Canadian DIN containing Bupivacaine, Combinations, across 12 DINs, of which 5 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| ASPEN PHARMACARE CANADA INC. | 2 | 2 | SENSORCAINE WITH EPINEPHRINE | Sourceable in Canada |
| PFIZER CANADA ULC | 2 | 2 | MARCAINE E | Sourceable in Canada |
| SEPTODONT INC | 2 | 1 | MARCAINE, VIVACAINE | Sourceable in Canada |
| SANOFI CANADA, INC. | 2 | 0 | MARCAINE E 0.25% LIQ PRT, MARCAINE E LIQ PRT 0.50% | No marketed DIN |
| CARESTREAM HEALTH CANADA COMPANY | 1 | 0 | MARCAINE | No marketed DIN |
| DENTSPLY CANADA LIMITED | 1 | 0 | SENSORCAINE FORTE | No marketed DIN |
| KODAK CANADA INC. | 1 | 0 | MARCAINE 0.5% AND EPINEPHRINE 1:200,000 LIQ | No marketed DIN |
| NOVOCOL PHARMACEUTICAL OF CANADA INC | 1 | 0 | BUPIVACAINE HCL 0.5% AND EPINEPHRINE 1:200,000 INJECTION | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 5 MG |
|---|---|
| Dosage form | SOLUTION |
| Route | BLOCK/INFILTRATION |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Bupivacaine, Combinations |
|---|---|
| ATC code | N01BB51 |
| AHFS class | 72:00.00 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02381850 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2381850 |
| Brand name | BUPIVACAINE HCL 0.5% AND EPINEPHRINE 1:200,000 INJECTION |
| Generic / active ingredient | BUPIVACAINE HYDROCHLORIDE : 5 MG EPINEPHRINE BITARTRATE : 0.0091 MG |
| Market authorization holder | NOVOCOL PHARMACEUTICAL OF CANADA INC |
| Health Canada schedule | Ethical |
| ATC code | N01BB51 |
| ATC anatomical main group | N — Nervous system |
| ATC therapeutic subgroup | N01BB |
| Current status | DORMANT |
| Status date | 16-Jul-2026 |
| Original market date | 2012-05-07 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
5 of 12 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| MARCAINE | 5 MG | SOLUTION | SEPTODONT INC | MARKETED | 02474247 |
| MARCAINE E | 0.182 MG / 20 ML | SOLUTION | PFIZER CANADA ULC | MARKETED | 02241916 |
| MARCAINE E | 50 MG / 20 ML | SOLUTION | PFIZER CANADA ULC | MARKETED | 02241915 |
| SENSORCAINE WITH EPINEPHRINE | 2.5 MG | SOLUTION | ASPEN PHARMACARE CANADA INC. | MARKETED | 01976184 |
| SENSORCAINE WITH EPINEPHRINE | 5 MG | SOLUTION | ASPEN PHARMACARE CANADA INC. | MARKETED | 01976206 |
| MARCAINE | 0.0091 MG | SOLUTION | CARESTREAM HEALTH CANADA COMPANY | CANCELLED POST MARKET | 02311887 |
| MARCAINE 0.5% AND EPINEPHRINE 1:200,000 LIQ | 9.1 MCG | LIQUID | KODAK CANADA INC. | CANCELLED POST MARKET | 01990616 |
| MARCAINE E 0.25% LIQ PRT | 2.5 MG | LIQUID | SANOFI CANADA, INC. | CANCELLED POST MARKET | 02018322 |
| MARCAINE E LIQ PRT 0.50% | 9.1 MCG | LIQUID | SANOFI CANADA, INC. | CANCELLED POST MARKET | 02018330 |
| SENSORCAINE FORTE | 5 MG | SOLUTION | DENTSPLY CANADA LIMITED | CANCELLED POST MARKET | 01976214 |
2 · Same class — other molecules in ATC N01BB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Lidocaine | AMNIOCENTESIS TRAY 1% · ANTECUBITAL CENT VENOUS CATHETERIZATION KIT · ARTHROGRAM TRAY 1% · ATELOCOLLAGEN IMPLANT · BASIC BIOPSY TRAY 1% · CATHEJELL · JELIDO · LARYNG O JET KIT · LIDOCAINE HCL INJ 1% · LIDOCAINE HCL INJ 10MG/ML USP · LIDOCAINE HCL INJECTION USP 1% (50 MG/5ML) · LIDOCAINE HCL INJECTION USP 1% (50MG/5ML) · LIDOCAINE HYDROCHLORIDE INJECTION · LIDOCAINE HYDROCHLORIDE INJECTION USP · LIDOCAINE HYDROCHLORIDE INJECTION USP 0.5% · LIDOCAINE HYDROCHLORIDE INJECTION USP 2% · LIDOCAINE HYDROCHLORIDE INJECTION, USP 1% · LIDOCAINE INJECTION BP · LIDODAN ENDOTRACHEAL NON-AEROSOL SPRAY · LIDODAN VISCOUS 2% · LUMBAR PUNCTURE TRAY 1% · LUMBAR PUNCTURE TRAY 1% PEDIATRIC/INFANT · MYELOGRAM TRAY 1% · PERCUTANEOUS SHEATH INTRODUCER KIT HL-09883 · PMS-LIDOCAINE VISCOUS 2% · PREATTACHED LTA KIT · SPINAL ANESTHESIA TRAY 1% · STALLION · THORACENTESIS TRAY 1% · XYLOCAINE 0.5% · XYLOCAINE 1.5% · XYLOCAINE 1% · XYLOCAINE 2% · XYLOCAINE 2% EPIDURAL · XYLOCAINE 5% SPINAL · XYLOCAINE CO2 INJ · XYLOCAINE JELLY 2% · XYLOCAINE MPF · XYLOCAINE MPF 1% · XYLOCAINE SPRAY · XYLOCAINE TOPICAL 4% · XYLOCAINE VISCOUS 2% · XYLOCAINE-MPF, 2% | 72 | 26 | Yes |
| Lidocaine, Combinations | 2% LIDOCAINE AND EPINEPHRINE 1:100,000 INJECTION USP · 5% XYLOCAINE MPF WITH GLUCOSE 7.5% INJECTION · ARROW CENTRAL VENOUS CATHETERIZATION KIT · ARROW MULTI-LUMEN CENTRAL VENOUS CATHETER KIT · ARROW PNEUMOTHORAX KIT · ARROW TWO-LUMEN CENTRAL VENOUS CATHETAR KIT · ARROW TWO-LUMEN JUGULAR CATHETERIZATION KIT · CENTRAL VEIN CATHETERIZATION KIT · CENTRAL VENOUS CATETHERIZATION KIT · CENTRAL VENOUS CATHETER EXPANDED KIT · CONTINUOUS EPIDURAL ANESTHESIA TRAY · DENTSPLY 2% LIDOCAINE WITH EPINEPHRINE 1:100,000 · DENTSPLY 2% LIDOCAINE WITH EPINEPHRINE 1:50,000 · EPIDURAL ANESTHESIA TRAY · EXPANDED MULTI-MED KIT · GENETIC AMNIOCENTESIS TRAY KIT · HYDROCATH CENTRAL VENOUS CATHETER KIT · INSTILLAGEL · JAMSHIDI BONE MARROW BIOPSY TRAY · JAMSHIDI MENGHINI SOFT TISSUE BIOPSY TRAY · LIDOCAINE 2% AND EPINEPHRINE 1:100 000 · LIDOCAINE 2% AND EPINEPHRINE 1:100,000 · LIDOCAINE 2% AND EPINEPHRINE 1:50 000 · LIDOCAINE 2% AND EPINEPHRINE 1:50,000 · LIDOCAINE AND EPINEPHRINE INJ.USP 2% 1:100000 · LIDOCAINE HYDROCHLORIDE 0.5% AND EPINEPHRINE 1:200000 INJECTION USP · LIDOCAINE HYDROCHLORIDE 1.5% AND EPINEPHRINE 1:200000 INJECTION USP · LIDOCAINE HYDROCHLORIDE 1.5% AND EPINEPHRINE 1:200000 INJECTION USP TEST DOSE · LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE INJECTION USP · LIGNOSPAN FORTE · LIGNOSPAN SPECIALE INJ · LIGNOSPAN STANDARD · MULTI-LUMEN CENTRAL VENOUS CATHET KIT · OCTOCAINE 100 NEEDLEJECT INJ · OCTOCAINE HCL 2% EPINEPHRINE 1:100000 · OCTOCAINE HCL 2% EPINEPHRINE 1:50000 · PARACENTESIS TRAY W BOASBERG CATHETER SET · PERCUTANEOUS SHEATH INTRO KIT AK-09810-S · PERCUTANEOUS SHEATH INTRODUCER TRAY · PERITONEAL LAVAGE KIT INJ · PLEURA-SEAL THORACENTESIS KIT · PLIAGLIS · SINGLE-SHOT EPIDURAL ANESTHESIA TRAY · SPINAL ANAESTHESIA TRAY · SPINAL ANESTHESIA TRAY · XYLOCAINE - MPF 5% WITH GLUCOSE 7.5% · XYLOCAINE 0.5% W EPINEPHRINE 1:100000 · XYLOCAINE 0.5% W EPINEPHRINE 1:200000 · XYLOCAINE 1.5% W EPINEPHRINE 1:200000 · XYLOCAINE 1.5% W EPINEPHRINE 1:200000 TEST DOSE · XYLOCAINE 1% W EPINEPHRINE 1:100000 · XYLOCAINE 1% W EPINEPHRINE 1:200000 · XYLOCAINE 2% W EPINEPHRINE 1:100000 · XYLOCAINE 2% W EPINEPHRINE 1:200000 · XYLOCAINE 2% WITH EPINEPHRINE 1:200000 · XYLOCAINE DENTAL LIDOCAINE HCL 2% AND EPINEPHRINE 1:100,000 · XYLOCAINE DENTAL LIDOCAINE HYDROCHLORIDE 2% AND EPINEPHRINE 1:50,000 · XYLOCAINE MPF 1.5% WITH EPINEPHRINE · XYLONOR | 72 | 16 | Yes |
| Articaine, Combinations | 4% ASTRACAINE DENTAL WITH EPINEPHRINE 1:200,000 (0.005MG/ML) · 4% ASTRACAINE DENTAL WITH EPINEPHRINE FORTE 1:100,000 (0.01MG/ML) · ARTICAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE INJECTION · ORABLOC 1:100,000 · ORABLOC 1:200,000 · POSICAINE N · POSICAINE SP · SEPTANEST N · SEPTANEST SP · ULTRACAINE D-S FORTE INJECTION · ULTRACAINE D-S INJECTION · ULTRACAINE DS FORTE INJ · ULTRACAINE DS INJ · ZORCAINE | 18 | 12 | Yes |
| Bupivacaine | BUPIVACAINE HEAVY INJECTION BP · BUPIVACAINE HYDROCHLORIDE IN DEXTROSE INJECTION USP · BUPIVACAINE HYDROCHLORIDE INJECTION USP · BUPIVACAINE HYDROCHLORIDE INJECTION USP .25% · BUPIVACAINE HYDROCHLORIDE INJECTION USP .50% · BUPIVACAINE HYDROCHLORIDE INJECTION USP .75% · BUPIVACAINE HYDROCHLORIDE INJECTION, USP · BUPIVACAINE INJECTION BP · JAMP-BUPIVACAINE · MARCAINE · MARCAINE 0.25% LIQ PRT 2.5MG/ML · MARCAINE 0.50% LIQ BIN 5MG/ML · MARCAINE 0.75% LIQ PRT 7.5MG/ML · MARCAINE 0.75% LIQ SPINAL 7.5MG/ML · MARCAINE SPINAL · SENSORCAINE | 42 | 10 | Yes |
| Mepivacaine | 3% POLOCAINE DENTAL · CARBOCAINE 1% · CARBOCAINE 2% · CARBOCAINE 3% · CARBOCAINE INJ LIQ 10MG/ML · CARBOCAINE INJ LIQ 20MG/ML · CARBOCAINE LIQ 1% · CARBOCAINE LIQ 2% · ISOCAINE HCL INJ 3% · MEPIVICAINE HYDROCHLORIDE INJECTION, USP 3% · SCANDONEST 3% PLAIN INJ | 15 | 7 | Yes |
| Ropivacaine | NAROPIN · NAROPIN INJ 7.5MG/ML · ROPIVACAINE HYDROCHLORIDE INJECTION · ROPIVACAINE HYDROCHLORIDE INJECTION USP · ROPIVACAINE HYDROCHLORIDE INJECTION, USP · XFUSOR | 13 | 6 | Yes |
| Bupivacaine, Combinations | BUPIVACAINE HCL 0.5% AND EPINEPHRINE 1:200,000 INJECTION · MARCAINE · MARCAINE 0.5% AND EPINEPHRINE 1:200,000 LIQ · MARCAINE E · MARCAINE E 0.25% LIQ PRT · MARCAINE E LIQ PRT 0.50% · SENSORCAINE FORTE · SENSORCAINE WITH EPINEPHRINE · VIVACAINE | 12 | 5 | Yes |
| Prilocaine, Combinations | 4% CITANEST FORTE DENTAL WITH EPINEPHRINE 1:200,000 · DENTSPLY 4% PRILOCAINE AND EPINEPHRINE INJECTION 1:200,000 · EMLA CREAM · EMLA PATCH · PRILOCAINE HCL 4% EPINEPH 1:200000INJ | 5 | 4 | Yes |
| Combinations | CETACAINE LIQUID · ORAQIX | 2 | 2 | Yes |
| Prilocaine | 4% CITANEST PLAIN DENTAL · DENTSPLY 4% PRILOCAINE HYDROCHLORIDE DENTAL INJECTION | 2 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC N01B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| N01BA | Benzocaine · Chloroprocaine · Combinations,Of Anesthetics · Procaine · Tetracaine | 13 | 1 |
| N01BX | Phenol | 1 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
How can I get it?
This DIN is dormant — it holds a Health Canada authorization but is not currently being marketed in Canada, so it cannot simply be ordered from Canadian stock. Where a patient need exists, supply may be possible through exceptional importation or the Special Access Programme, subject to Health Canada's requirements and the prescriber's application. Nexara can advise on the route and on marketed alternatives.
Ask about sourcing BUPIVACAINE HCL 0.5% AND EPINEPHRINE 1:200,000 INJECTION
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.