ARESTIN MICROSPHERES 1 MG / 4 MG — DIN 02278219
MINOCYCLINE (MINOCYCLINE HYDROCHLORIDE) : 1 MG / 4 MG · ORA PHARMA INC. · POWDER (EXTENDED RELEASE) · wholesale supply in Canada
Health Canada status: MARKETED
What is ARESTIN MICROSPHERES?
ARESTIN MICROSPHERES 1 MG / 4 MG contains MINOCYCLINE (MINOCYCLINE HYDROCHLORIDE) : 1 MG / 4 MG. It is listed in the Health Canada Drug Product Database under DIN 02278219, held by ORA PHARMA INC., supplied as POWDER (EXTENDED RELEASE) for SUBGINGIVAL administration. Health Canada currently lists it as marketed, status dated 20-Jan-2011. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is ARESTIN MICROSPHERES used for?
ARESTIN MICROSPHERES (minocycline hydrochloride) is indicated as an adjunct to scaling and root planning (SRP) procedures to decrease pocket depth (PD) in adult patients with chronic periodontitis. ARESTIN MICROSPHERES is administered with SRP to help further reduce PD in the treatment of adult patients with moderate to advanced chronic periodontal disease. ARESTIN MICROSPHERES may be used as part of a periodontal maintenance program which includes good oral hygiene and SRP.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Minocycline cost around the world?
Minocycline is listed on 7 of the national price registers Nexara ingests. Each country publishes on a different basis, so figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Greece publishes a producer price (ex-factory); Iceland publishes a max wholesale. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed |
|---|---|---|---|
| United States | acquisition | 6 | 29 |
| Saudi Arabia | public | 6 | 6 |
| South Africa | single exit price | 3 | 6 |
| Australia | ex-manufacturer | 2 | 4 |
| Greece | producer price (ex-factory) | 2 | 2 |
| Iceland | max wholesale | 2 | 2 |
| Morocco | PPV (public price) | 2 | 2 |
51 pack listings across 23 brand entries and 7 price bases, refreshed 08 Sep 2026. Ranges span every Minocycline pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 1 MG / 4 MG |
|---|---|
| Dosage form | POWDER (EXTENDED RELEASE) |
| Route | SUBGINGIVAL |
| Pack configuration (monograph) | 12 cartridges are packaged in one tray with desiccant in a heat-sealed foil laminate resealable pouch. Each cartridge contains 4 mg of powder made up of minocycline hydrochloride and poly (glycolide - co - DL-lactide), PGLA. There is one pouch (total of 12 units) or two pouches (total of 24 units) in each box. |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation, because this listing covers more than one of them.
Substance and classification
| Active substance | Minocycline |
|---|---|
| ATC code | A01AB23 |
| AHFS class | 52:04.04 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02278219 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2278219 |
| Brand name | ARESTIN MICROSPHERES |
| Generic / active ingredient | MINOCYCLINE (MINOCYCLINE HYDROCHLORIDE) : 1 MG / 4 MG |
| Market authorization holder | ORA PHARMA INC. |
| Health Canada schedule | Prescription |
| ATC code | A01AB23 |
| ATC anatomical main group | A — Alimentary tract and metabolism |
| ATC therapeutic subgroup | A01AB |
| Current status | MARKETED |
| Status date | 20-Jan-2011 |
| Original market date | 2008-07-27 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
2 · Same class — other molecules in ATC A01AB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Chlorhexidine | CHLORHEXIDINE · CHLORHEXIDINE ALCOHOL FREE · CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE, USP · DENTICARE CHLORHEXIDINE GLUCONATE ORAL RINSE 0.12% · +13 more | 19 | 8 | Yes |
| Doxycycline | ATRIDOX · JAMP DOXYCYCLINE · PMS-DOXYCYCLINE | 4 | 2 | Yes |
| Minocycline | ARESTIN MICROSPHERES | 1 | 1 | Yes |
| Domiphen | ANTISEPTIQUE PASTILLE 1.5MG CERISE · ANTISEPTIQUE PASTILLE 1.5MG CITRON · ANTISEPTIQUE PASTILLE 1.5MG MENTHE · ANTISEPTIQUE PASTILLE 1.5MG MIEL EUCALYPTUS · +8 more | 12 | 0 | Not in Canada |
| Various | BABY'S OWN TEETHING GEL - 2.5% · CAMPHORATED PARA CHLOROPHENOL LIQ · ENDOPEROX 100% · ROOT CANAL THERAPY | 4 | 0 | Not in Canada |
| Hydrogen Peroxide | ORAJEL PERIOSEPTIC RINSE - 1.5% · PERIOSELECT HYDROGEN PEROXIDE SOLUTION 1.7% | 2 | 0 | Not in Canada |
| Hexetidine | STERI/SOL LIQUID | 1 | 0 | Not in Canada |
| Antiinfectives For Local Oral Treatment | BISCO CAVITY CLEANSER LIQ 0.2% | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC A01A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| A01AD | Amlexanox · Benzydamine · Epinephrine · Epinephrine, Combinations · Other Agents For Local Oral Treatment · +1 more | 146 | 5 |
| A01AC | Corticosteroids For Local Oral Treatment · Dexamethasone, Combinations * · Prednisolone, Combinations · Triamcinolone | 7 | 1 |
| A01AA | Caries Prophylactic Agents · Combination (Caries Prophylactic Agents) · Sodium Fluoride · Sodium Fluoride, Combinations · Sodium Monofluorophosphate · +2 more | 226 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is ARESTIN MICROSPHERES called?
The same molecule, Minocycline, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Sandoz Minocycline | Latin | South Africa |
| Cyclimycin | Latin | South Africa |
| Minostad | Latin | Iceland |
| MINOTREX | Latin | Morocco |
| MYNOCINE | Latin | Morocco |
| Skid | Latin | Iceland |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.