APO-SALVENT-IPRAVENT STERULES 2.5 MG / 2.5 ML — DIN 02266393
SALBUTAMOL (SALBUTAMOL SULFATE) : 2.5 MG / 2.5 ML IPRATROPIUM BROMIDE (IPRATROPIUM BROMIDE MONOHYDRATE) : 0.5 MG / 2.5 ML · APOTEX INC · SOLUTION · wholesale supply in Canada
Health Canada status: DORMANT
What is APO-SALVENT-IPRAVENT STERULES?
APO-SALVENT-IPRAVENT STERULES 2.5 MG / 2.5 ML contains SALBUTAMOL (SALBUTAMOL SULFATE) : 2.5 MG / 2.5 ML IPRATROPIUM BROMIDE (IPRATROPIUM BROMIDE MONOHYDRATE) : 0.5 MG / 2.5 ML. It is listed in the Health Canada Drug Product Database under DIN 02266393, held by APOTEX INC, supplied as SOLUTION for INHALATION administration. Health Canada currently lists it as dormant, status dated 04-Aug-2017. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A). This DIN is not currently being marketed in Canada, so it is sourced to order where a compliant route exists rather than held in stock.
What is APO-SALVENT-IPRAVENT STERULES used for?
Treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD).
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Salbutamol And Ipratropium Bromide cost around the world?
Salbutamol And Ipratropium Bromide is listed on 16 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Bahrain publishes a retail (max). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Saudi Arabia | public | 39 | 42 | SAR███.██ |
| Morocco | PPV (public price) | 13 | 34 | MAD███.██ |
| South Africa | single exit price | 25 | 31 | ZAR███.██ |
| Australia | ex-manufacturer | 8 | 17 | AUD███.██ |
| Czechia | max producer price (ex-factory) | 4 | 9 | CZK███.██ |
| Romania | max producer price | 6 | 6 | RON███.██ |
| Austria | KVP (Kassenverkaufspreis) | 5 | 5 | EUR███.██ |
| Greece | producer price (ex-factory) | 5 | 5 | EUR███.██ |
| United Kingdom | hospital | 4 | 4 | GBP███.██ |
| Luxembourg | reimbursement | 3 | 3 | EUR███.██ |
| Bahrain | retail (max) | 2 | 2 | BHD███.██ |
| Spain | PVP con IVA (public price) | 2 | 2 | EUR███.██ |
| Sweden | AIP (pharmacy purchase price) | 2 | 2 | SEK███.██ |
| Iceland | max wholesale | 1 | 1 | ISK███.██ |
| Lebanon | public price (USD, Decision 119/1) | 1 | 1 | USD███.██ |
| Slovakia | categorised final price | 1 | 1 | EUR███.██ |
165 pack listings across 121 brand entries and 16 price bases, refreshed 08 Sep 2026. Ranges span every Salbutamol And Ipratropium Bromide pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Salbutamol And Ipratropium Bromide in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
5 holders have a Canadian DIN containing Salbutamol And Ipratropium Bromide, across 7 DINs, of which 3 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| BOEHRINGER INGELHEIM (CANADA) LTD LTEE | 2 | 1 | COMBIVENT RESPIMAT, COMBIVENT UDV | Sourceable in Canada |
| TEVA CANADA LIMITED | 2 | 1 | RATIO-IPRA SAL UDV, TEVA-COMBO STERINEBS | Sourceable in Canada |
| JUNO PHARMACEUTICALS CORP. | 1 | 1 | IPRATROPIUM BROMIDE AND SALBUTAMOL SULPHATE INHALATION SOLUTION | Sourceable in Canada |
| APOTEX INC | 1 | 0 | APO-SALVENT-IPRAVENT STERULES | No marketed DIN |
| IVAX PHARMACEUTICALS INCORPORATED | 1 | 0 | IPRAMOL | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 2.5 MG / 2.5 ML |
|---|---|
| Dosage form | SOLUTION |
| Route | INHALATION |
| Pack configuration (monograph) | 2.5 mL sterules (further details not provided in text snippet). |
| Storage | Store at 15-30°C (implied by standard monograph sections, though specific text was truncated; summary product info mentions stability). |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation, because this listing covers more than one of them.
Substance and classification
| Active substance | Salbutamol And Ipratropium Bromide |
|---|---|
| ATC code | R03AL02 |
| AHFS class | 48:12.04.12 ; 12:08.08 ; 12:12.08.12 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02266393 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2266393 |
| Brand name | APO-SALVENT-IPRAVENT STERULES |
| Generic / active ingredient | SALBUTAMOL (SALBUTAMOL SULFATE) : 2.5 MG / 2.5 ML IPRATROPIUM BROMIDE (IPRATROPIUM BROMIDE MONOHYDRATE) : 0.5 MG / 2.5 ML |
| Market authorization holder | APOTEX INC |
| Health Canada schedule | Prescription |
| ATC code | R03AL02 |
| ATC anatomical main group | R — Respiratory system |
| ATC therapeutic subgroup | R03AL |
| Current status | DORMANT |
| Status date | 04-Aug-2017 |
| Original market date | 2006-08-25 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Administered via nebulizer. Treatment should be initiated under medical supervision. Administration should stop when sufficient symptom relief is achieved. Not for oral or parenteral use.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity to components or atropine/derivatives; cardiac tachyarrhythmias; hypertrophic obstructive cardiomyopathy.
Warnings and precautions
Risk of paradoxical bronchospasm, cardiovascular effects (myocardial ischaemia), worsening of narrow-angle glaucoma, urinary retention, and hypokalemia. Avoid contact with eyes.
Is Salbutamol And Ipratropium Bromide in shortage in Canada?
A Canadian shortage report is on file for a product containing this molecule: Resolved — reported by SANIS HEALTH INC, last seen 09 Sep 2026. A shortage on one presentation does not always affect every DIN of the molecule — the alternatives below list what else is marketed in Canada. Nexara can confirm current availability and identify substitutions or import options where permitted.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
3 of 7 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| COMBIVENT RESPIMAT | 20 MCG | SOLUTION | BOEHRINGER INGELHEIM (CANADA) LTD LTEE | MARKETED | 02419106 |
| IPRATROPIUM BROMIDE AND SALBUTAMOL SULPHATE INHALATION SOLUTION | 2.5 MG / 2.5 ML | SOLUTION | JUNO PHARMACEUTICALS CORP. | MARKETED | 02483394 |
| TEVA-COMBO STERINEBS | 2.5 MG / 2.5 ML | SOLUTION | TEVA CANADA LIMITED | MARKETED | 02272695 |
| COMBIVENT UDV | 2.5 MG / 2.5 ML | SOLUTION | BOEHRINGER INGELHEIM (CANADA) LTD LTEE | CANCELLED POST MARKET | 02231675 |
| IPRAMOL | 2.5 MG / 2.5 ML | SOLUTION | IVAX PHARMACEUTICALS INCORPORATED | CANCELLED PRE MARKET | 02264609 |
| RATIO-IPRA SAL UDV | 0.5 MG / 2.5 ML | SOLUTION | TEVA CANADA LIMITED | CANCELLED POST MARKET | 02243789 |
2 · Same class — other molecules in ATC R03AL
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Salbutamol And Ipratropium Bromide | APO-SALVENT-IPRAVENT STERULES · COMBIVENT RESPIMAT · COMBIVENT UDV · IPRAMOL · +3 more | 7 | 3 | Yes |
| Vilanterol, Umeclidinium Bromide And Fluticasone Furoate | TRELEGY ELLIPTA | 2 | 2 | Yes |
| Formoterol, Glycopyrronium Bromide And Budesonide | BREZTRI AEROSPHERE | 1 | 1 | Yes |
| Indacaterol And Glycopyrronium Bromide | ULTIBRO BREEZHALER | 1 | 1 | Yes |
| Formoterol And Aclidinium Bromide | DUAKLIR GENUAIR | 1 | 1 | Yes |
| Indacaterol, Glycopyrronium Bromide And Mometasone | ENERZAIR BREEZHALER | 1 | 1 | Yes |
| Olodaterol And Tiotropium Bromide | INSPIOLTO RESPIMAT | 1 | 1 | Yes |
| Vilanterol And Umeclidinium Bromide | ANORO ELLIPTA | 1 | 1 | Yes |
| Fenoterol And Ipratropium Bromide | DUOVENT UDV | 1 | 0 | Not in Canada |
| Formoterol, Glycopyrronium Bromide And Beclometasone | TRIMBOW | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC R03A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| R03AK | Formoterol And Budesonide · Formoterol And Mometasone · Indacaterol And Mometasone · Salbutamol And Sodium Cromoglicate · Salmeterol And Fluticasone · +1 more | 26 | 20 |
| R03AC | Fenoterol · Formoterol · Indacaterol · Olodaterol · Pirbuterol · +4 more | 81 | 15 |
| R03AA | Epinephrine | 4 | 0 |
| R03AB | Isoprenaline · Orciprenaline | 6 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is APO-SALVENT-IPRAVENT STERULES called?
The same molecule, Salbutamol And Ipratropium Bromide, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| DILATOR | Latin | Morocco |
| Ventolin | Latin | Australia, Czechia, Saudi Arabia, Slovakia |
| VENTOLINE | Latin | Morocco |
| BUTAMYL | Latin | Morocco |
| BUVENTOL EASYHALER | Latin | Czechia |
| Ventolin Nebules | Latin | Australia |
| BULMOL | Latin | Morocco |
| INALER | Latin | Morocco |
| Salbutamol Cipla | Latin | Australia |
| Airomir Autohaler | Latin | Australia, South Africa |
| Asthavent Ecohaler | Latin | South Africa |
| Asthavent Syrup | Latin | South Africa |
| BUTOVENT | Latin | Morocco |
| DILATOR ECOSPRAY | Latin | Morocco |
| MAGISTRAL | Latin | Morocco |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
This DIN is dormant — it holds a Health Canada authorization but is not currently being marketed in Canada, so it cannot simply be ordered from Canadian stock. Where a patient need exists, supply may be possible through exceptional importation or the Special Access Programme, subject to Health Canada's requirements and the prescriber's application. Nexara can advise on the route and on marketed alternatives.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.