APO-TIZANIDINE 4 MG
TIZANIDINE (TIZANIDINE HYDROCHLORIDE) : 4 MG · DIN 02259893 · APOTEX INC
Health Canada status: MARKETED
What is APO-TIZANIDINE?
APO-TIZANIDINE 4 MG contains TIZANIDINE (TIZANIDINE HYDROCHLORIDE) : 4 MG. It is listed in the Health Canada Drug Product Database under DIN 02259893, held by APOTEX INC, supplied as TABLET for ORAL administration. Health Canada currently lists it as marketed, status dated 06-May-2024. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is APO-TIZANIDINE used for?
Short-acting drug indicated for the management of spasticity in adults.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
Product details and regulatory record
| DIN | 02259893 |
|---|---|
| Brand name | APO-TIZANIDINE |
| Generic / active ingredient | TIZANIDINE (TIZANIDINE HYDROCHLORIDE) : 4 MG |
| Manufacturer | APOTEX INC |
| Strength | 4 MG |
| Dosage form | TABLET |
| Route of administration | ORAL |
| Schedule | Prescription |
| ATC code | M03BX02 TIZANIDINE |
| AHFS class | 12:20.04 |
| Biosimilar | No |
| Health Canada status | MARKETED |
| Status date | 06-May-2024 |
| Original market date | 2004-11-17 00:00:00 |
How is it administered?
Start with 2 mg single dose. Increase by 2-4 mg steps to effect. Repeat every 6-8 hours as needed (max 3 doses/24 hours). Max daily dose 36 mg. Taper slowly to discontinue.
Included because it drives pack selection and wastage. Consult the monograph.
How is it stored and handled?
Not explicitly stated in provided text (standard practice is 15-30°C, but text ends at section 8).
How is it supplied?
Bottles of 100 tablets.
Contraindications
Hypersensitivity to tizanidine; co-administration with moderate/potent CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin); where spasticity is needed to maintain function/balance.
Warnings and precautions
Risk of dose-related hypotension, bradycardia, and sedation. Potential for drug-induced liver injury (monitor ALT/AST). Hallucinations/psychotic symptoms may occur. Risk of withdrawal rebound.
What can be used instead?
Other Canadian products sharing ATC code M03BX02 TIZANIDINE. 2 of 5 DINs in this group are currently marketed — marketed products are listed first, because that is what can actually be bought. These tables describe supply, not clinical equivalence: substitution rests with the prescriber or pharmacist, and interchangeability is determined provincially.
| Product | Strength | Form | Manufacturer | Health Canada status | DIN |
|---|---|---|---|---|---|
| MINT-TIZANIDINE | 4 MG | TABLET | MINT PHARMACEUTICALS INC | MARKETED | DIN 02536765 |
| APO-TIZANIDINE | 2 MG | TABLET | APOTEX INC | APPROVED | DIN 02259885 |
| MYLAN-TIZANIDINE | 4 MG | TABLET | MYLAN PHARMACEUTICALS ULC | CANCELLED POST MARKET | DIN 02272059 |
| PAL-TIZANIDINE | 4 MG | TABLET | PALADIN PHARMA INC. | CANCELLED POST MARKET | DIN 02239170 |
Who else supplies TIZANIDINE worldwide?
Nexara tracks national medicine registries and published price lists across multiple markets. TIZANIDINE appears in 3 registered pack listings across 2 markets, published on 1 different national price bases. Where a Canadian route is closed, that is where an alternative route of supply starts — subject to the import rules in both countries.
Registered listings are not stock. Ask us to confirm what can actually be sourced for your order.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.