PYLERA 40 MG — DIN 02246962
BISMUTH OXIDE (BISMUTH SUBCITRATE POTASSIUM) : 40 MG METRONIDAZOLE : 125 MG TETRACYCLINE HYDROCHLORIDE : 125 MG · LABORATOIRES JUVISE PHARMACEUTICALS · CAPSULE · wholesale supply in Canada
Health Canada status: MARKETED
What is PYLERA?
PYLERA 40 MG contains BISMUTH OXIDE (BISMUTH SUBCITRATE POTASSIUM) : 40 MG METRONIDAZOLE : 125 MG TETRACYCLINE HYDROCHLORIDE : 125 MG. It is listed in the Health Canada Drug Product Database under DIN 02246962, held by LABORATOIRES JUVISE PHARMACEUTICALS, supplied as CAPSULE for ORAL administration. Health Canada currently lists it as marketed, status dated 11-Dec-2025. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is PYLERA used for?
Eradication of H. pylori in patients with H. pylori infection and active duodenal ulcer (or history of) in conjunction with omeprazole.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Bismuth Subcitrate,Tetracycline And Metronidazole cost around the world?
Bismuth Subcitrate,Tetracycline And Metronidazole is listed on 2 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Greece publishes a producer price (ex-factory); United States publishes a acquisition. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 1 | 2 | USD███.██ |
| Greece | producer price (ex-factory) | 1 | 1 | EUR███.██ |
3 pack listings across 2 brand entries and 2 price bases, refreshed 03 Sep 2026. Ranges span every Bismuth Subcitrate,Tetracycline And Metronidazole pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 40 MG |
|---|---|
| Dosage form | CAPSULE |
| Route | ORAL |
| Pack configuration (monograph) | Bottles of 120 capsules. |
| Storage | Not explicitly detailed in provided text (section 11 header present but content truncated), though standard pharmaceutical storage is implied. |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Bismuth Subcitrate,Tetracycline And Metronidazole |
|---|---|
| ATC code | A02BD08 |
| AHFS class | 08:30.92 ; 08:12.24 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02246962 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2246962 |
| Brand name | PYLERA |
| Generic / active ingredient | BISMUTH OXIDE (BISMUTH SUBCITRATE POTASSIUM) : 40 MG METRONIDAZOLE : 125 MG TETRACYCLINE HYDROCHLORIDE : 125 MG |
| Market authorization holder | LABORATOIRES JUVISE PHARMACEUTICALS |
| Health Canada schedule | Prescription |
| ATC code | A02BD08 |
| ATC anatomical main group | A — Alimentary tract and metabolism |
| ATC therapeutic subgroup | A02BD |
| Current status | MARKETED |
| Status date | 11-Dec-2025 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Three capsules four times daily (after meals and at bedtime) for 10 days, in combination with omeprazole 20 mg twice daily. Swallow whole with 250 mL water.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity to components; pregnancy/breast-feeding; pediatric population; renal or hepatic impairment; Cockayne syndrome; active neurological disorders; history of blood dyscrasia.
Warnings and precautions
Risk of encephalopathy, peripheral neuropathy, seizures, and severe cutaneous adverse reactions (SCARs). Avoid alcohol. Potential for permanent tooth discoloration in young children.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
2 · Same class — other molecules in ATC A02BD
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Lansoprazole, Amoxicillin And Clarithromycin | AA-LANSOPRAZOLE-AMOXICILLIN-CLARITHROMYCIN · HP-PAC | 2 | 1 | Yes |
| Bismuth Subcitrate,Tetracycline And Metronidazole | PYLERA | 1 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC A02B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| A02BC | Dexlansoprazole · Esomeprazole · Lansoprazole · Omeprazole · Pantoprazole · +1 more | 288 | 108 |
| A02BA | Cimetidine · Famotidine · Famotidine, Combinations · Nizatidine · Ranitidine · +1 more | 235 | 26 |
| A02BX | Alginic Acid · Pirenzepine · Sucralfate | 32 | 4 |
| A02BB | Misoprostol | 10 | 2 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.