PEGETRON 100 MCG / 0.5 ML — DIN 02246028
PEGINTERFERON ALFA-2B : 100 MCG / 0.5 ML RIBAVIRIN : 200 MG · MERCK CANADA INC · CAPSULE ; POWDER FOR SOLUTION · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is PEGETRON?
PEGETRON 100 MCG / 0.5 ML contains PEGINTERFERON ALFA-2B : 100 MCG / 0.5 ML RIBAVIRIN : 200 MG. It is listed in the Health Canada Drug Product Database under DIN 02246028, held by MERCK CANADA INC, supplied as CAPSULE ; POWDER FOR SOLUTION for ORAL ; SUBCUTANEOUS administration. Health Canada currently lists it as cancelled post market, status dated 23-Jan-2013. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
What is PEGETRON used for?
Treatment of chronic hepatitis C in adults (>= 18 years) with compensated liver disease and positive HCV-RNA, including treatment-naive and prior treatment failures.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
Is there a generic Peginterferon Alfa-2b, Combinations in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
2 holders have a Canadian DIN containing Peginterferon Alfa-2b, Combinations, across 15 DINs, of which 0 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| MERCK CANADA INC | 13 | 0 | PEGETRON, VICTRELIS TRIPLE | No marketed DIN |
| SCHERING-PLOUGH CANADA INC | 2 | 0 | REBETRON READY TO USE SOLUTION (ALBUMIN(HUMAN)FREE) (6000000 IU/ML AND 200MG CAPSULES), REBETRON SOLUTION (ALBUMIN (HUMAN) FREE) (18 MIU MULTI-DOSE PEN / 200MG CAPSULES) | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 100 MCG / 0.5 ML |
|---|---|
| Dosage form | CAPSULE ; POWDER FOR SOLUTION |
| Route | ORAL ; SUBCUTANEOUS |
| Pack configuration (monograph) | Ribavirin 200 mg capsules; Peginterferon alfa-2b powder in vials or REDIPEN Single Dose Delivery System (50, 80, 100, 120, 150 mcg/0.5 mL). |
| Storage | Not explicitly detailed in provided text summary (refer to full Storage and Stability section 38). |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Peginterferon Alfa-2b, Combinations |
|---|---|
| ATC code | L03AB60 |
| AHFS class | 08:18.20 ; 08:18.32 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02246028 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2246028 |
| Brand name | PEGETRON |
| Generic / active ingredient | PEGINTERFERON ALFA-2B : 100 MCG / 0.5 ML RIBAVIRIN : 200 MG |
| Market authorization holder | MERCK CANADA INC |
| Health Canada schedule | Schedule D |
| ATC code | L03AB60 |
| ATC anatomical main group | L — Antineoplastic and immunomodulating agents |
| ATC therapeutic subgroup | L03AB |
| Current status | CANCELLED POST MARKET |
| Status date | 23-Jan-2013 |
| Original market date | 2002-08-13 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Combination therapy: ribavirin capsules (oral) plus peginterferon alfa-2b (subcutaneous). Dose modifications required for toxicity or cardiac patients. Discontinue if CrCl < 50 mL/min.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity to interferons/ribavirin; Pregnancy (patients and male partners); Autoimmune hepatitis; Severe psychiatric disorders; Thyroid abnormalities; Renal dysfunction (CrCl < 50 mL/min).
Warnings and precautions
Serious neuropsychiatric, autoimmune, ischemic, and infectious disorders. Life-threatening psychiatric effects (suicide). Bone marrow toxicity, cardiovascular events, and pulmonary infiltrates.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
0 of 15 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| PEGETRON | 200 MG | CAPSULE ; POWDER FOR SOLUTION | MERCK CANADA INC | CANCELLED POST MARKET | 02254638 |
| PEGETRON | 200 MG | CAPSULE ; POWDER FOR SOLUTION | MERCK CANADA INC | CANCELLED POST MARKET | 02254646 |
| PEGETRON | 50 MCG / 0.5 ML | POWDER FOR SOLUTION ; CAPSULE | MERCK CANADA INC | CANCELLED POST MARKET | 02246026 |
| PEGETRON | 200 MG | POWDER FOR SOLUTION ; CAPSULE | MERCK CANADA INC | CANCELLED POST MARKET | 02246027 |
| PEGETRON | 200 MG | CAPSULE ; POWDER FOR SOLUTION | MERCK CANADA INC | CANCELLED POST MARKET | 02246029 |
| PEGETRON | 150 MCG / 0.5 ML | CAPSULE ; POWDER FOR SOLUTION | MERCK CANADA INC | CANCELLED POST MARKET | 02246030 |
| PEGETRON | 80 MCG / 0.5 ML | POWDER FOR SOLUTION ; CAPSULE | MERCK CANADA INC | CANCELLED POST MARKET | 02254581 |
| PEGETRON | 200 MG | CAPSULE ; POWDER FOR SOLUTION | MERCK CANADA INC | CANCELLED POST MARKET | 02254603 |
| REBETRON READY TO USE SOLUTION (ALBUMIN(HUMAN)FREE) (6000000 IU/ML AND 200MG CAPSULES) | 200 MG | KIT ; CAPSULE ; LIQUID | SCHERING-PLOUGH CANADA INC | CANCELLED POST MARKET | 02239730 |
| REBETRON SOLUTION (ALBUMIN (HUMAN) FREE) (18 MIU MULTI-DOSE PEN / 200MG CAPSULES) | 200 MG | KIT ; LIQUID ; CAPSULE | SCHERING-PLOUGH CANADA INC | CANCELLED POST MARKET | 02241159 |
2 · Same class — other molecules in ATC L03AB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Interferon Beta-1a | AVONEX · REBIF | 11 | 5 | Yes |
| Peginterferon Beta-1a | PLEGRIDY | 4 | 2 | Yes |
| Interferon Beta-1b | BETASERON · EXTAVIA | 2 | 1 | Yes |
| Peginterferon Alfa-2a | PEGASYS | 2 | 1 | Yes |
| Peginterferon Alfa-2b, Combinations | PEGETRON · REBETRON READY TO USE SOLUTION (ALBUMIN(HUMAN)FREE) (6000000 IU/ML AND 200MG CAPSULES) · REBETRON SOLUTION (ALBUMIN (HUMAN) FREE) (18 MIU MULTI-DOSE PEN / 200MG CAPSULES) · VICTRELIS TRIPLE | 15 | 0 | Not in Canada |
| Interferon Alfa-2b | INTRON A · INTRON A - KIT (PWS+DILUENT) 3000000IU/VIAL · INTRON A - KIT (PWS+DILUENT) 5000000IU/VIAL · INTRON A - LIQ 5000000IU/ML · +3 more | 13 | 0 | Not in Canada |
| Interferon Alfa-2a | ROFERON A SOLN INJ 6 MILLION · ROFERON A STERILE PWS 18M UNIT/VIAL · ROFERON A STERILE PWS 3M UNIT/VIAL · ROFERON A STERILE PWS 9M UNIT/VIAL · +8 more | 12 | 0 | Not in Canada |
| Peginterferon Alfa-2b | UNITRON PEG | 4 | 0 | Not in Canada |
| Peginterferon Alfa-2a, Combinations | PEGASYS RBV | 2 | 0 | Not in Canada |
| Interferon Alfa-N1 | WELLFERON INJ 10 000 000UNIT/ML · WELLFERON INJ 3000000UNIT/ML | 2 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC L03A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| L03AA | Ancestim · Filgrastim · Pegfilgrastim | 24 | 21 |
| L03AX | Bcg Vaccine · Glatiramer Acetate · Melanoma Vaccine · Plerixafor | 18 | 8 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.