NEXIUM - 40MG 40 MG — DIN 02244522
ESOMEPRAZOLE (ESOMEPRAZOLE MAGNESIUM TRIHYDRATE) : 40 MG · ASTRAZENECA CANADA INC · TABLET (DELAYED-RELEASE) · wholesale supply in Canada
Health Canada status: MARKETED
What is NEXIUM - 40MG?
NEXIUM - 40MG 40 MG contains ESOMEPRAZOLE (ESOMEPRAZOLE MAGNESIUM TRIHYDRATE) : 40 MG. It is listed in the Health Canada Drug Product Database under DIN 02244522, held by ASTRAZENECA CANADA INC, supplied as TABLET (DELAYED-RELEASE) for ORAL administration. Health Canada currently lists it as marketed, status dated 20-Aug-2001. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is NEXIUM - 40MG used for?
Reflux esophagitis, NERD, healing/risk-reduction of NSAID-associated gastric ulcers, Zollinger-Ellison syndrome, H. pylori eradication (with antibiotics). Pediatrics (1-17): GERD and NERD.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Esomeprazole cost around the world?
Esomeprazole is listed on 10 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Bahrain publishes a retail (max). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Australia | ex-manufacturer | 11 | 143 | AUD███.██ |
| South Africa | single exit price | 48 | 63 | ZAR███.██ |
| Austria | KVP (Kassenverkaufspreis) | 23 | 46 | EUR███.██ |
| Saudi Arabia | public | 15 | 28 | SAR███.██ |
| Morocco | PPV (public price) | 7 | 20 | MAD███.██ |
| Bahrain | retail (max) | 9 | 18 | BHD███.██ |
| Luxembourg | reimbursement | 16 | 16 | EUR███.██ |
| Greece | producer price (ex-factory) | 14 | 14 | EUR███.██ |
| Czechia | max producer price (ex-factory) | 3 | 11 | CZK███.██ |
| United Kingdom | hospital | 4 | 4 | GBP███.██ |
363 pack listings across 150 brand entries and 10 price bases, refreshed 08 Sep 2026. Ranges span every Esomeprazole pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Esomeprazole in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
16 holders have a Canadian DIN containing Esomeprazole, across 46 DINs, of which 26 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| ASTRAZENECA CANADA INC | 3 | 3 | NEXIUM, NEXIUM - 20MG, NEXIUM - 40MG | Sourceable in Canada |
| LABORATOIRE RIVA INC. | 6 | 2 | ESOMEPRAZOLE DR, RIVA-ESOMEPRAZOLE, RIVA-ESOMEPRAZOLE DR | Sourceable in Canada |
| MYLAN PHARMACEUTICALS ULC | 6 | 2 | MYL-ESOMEPRAZOLE, MYLAN-ESOMEPRAZOLE | Sourceable in Canada |
| APOTEX INC | 4 | 2 | APO-ESOMEPRAZOLE, APO-ESOMEPRAZOLE DELAYED-RELEASE | Sourceable in Canada |
| PHARMASCIENCE INC | 4 | 2 | PMS-ESOMEPRAZOLE DR, PMSC-ESOMEPRAZOLE DR | Sourceable in Canada |
| TEVA CANADA LIMITED | 4 | 2 | ESOMEPRAZOLE, TEVA-ESOMEPRAZOLE | Sourceable in Canada |
| JAMP PHARMA CORPORATION | 2 | 2 | ESOMEPRAZOLE | Sourceable in Canada |
| MANTRA PHARMA INC | 2 | 2 | M-ESOMEPRAZOLE | Sourceable in Canada |
| PRO DOC LIMITEE | 2 | 2 | ESOMEPRAZOLE | Sourceable in Canada |
| SANDOZ CANADA INCORPORATED | 2 | 2 | SANDOZ ESOMEPRAZOLE | Sourceable in Canada |
| SIVEM PHARMACEUTICALS ULC | 2 | 2 | ESOMEPRAZOLE | Sourceable in Canada |
| SUN PHARMA CANADA INC | 2 | 2 | TARO-ESOMEPRAZOLE | Sourceable in Canada |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 40 MG |
|---|---|
| Dosage form | TABLET (DELAYED-RELEASE) |
| Route | ORAL |
| Pack configuration (monograph) | 20 mg tablets: Blister packs of 28. 40 mg tablets: Blister packs of 28 or HDPE bottles of 100. 10 mg granules: Unit dose sachets in cartons of 30. |
| Storage | Store at room temperature (15-30°C). Keep container tightly closed (bottles). Use reconstituted suspension within 30 minutes. |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation, because this listing covers more than one of them.
Substance and classification
| Active substance | Esomeprazole |
|---|---|
| ATC code | A02BC05 |
| AHFS class | 56:28.36 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02244522 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2244522 |
| Brand name | NEXIUM - 40MG |
| Generic / active ingredient | ESOMEPRAZOLE (ESOMEPRAZOLE MAGNESIUM TRIHYDRATE) : 40 MG |
| Market authorization holder | ASTRAZENECA CANADA INC |
| Health Canada schedule | Prescription |
| ATC code | A02BC05 |
| ATC anatomical main group | A — Alimentary tract and metabolism |
| ATC therapeutic subgroup | A02BC |
| Current status | MARKETED |
| Status date | 20-Aug-2001 |
| Original market date | 2001-08-20 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
Adults: 20-40 mg once daily depending on indication. H. pylori: 20 mg BID with antibiotics for 7 days. Zollinger-Ellison: 40 mg BID initially. Pediatrics (1-17): Dose based on weight/age.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Hypersensitivity to esomeprazole or substituted benzimidazoles; co-administration with rilpivirine. When used for H. pylori eradication, see amoxicillin and clarithromycin monographs.
Warnings and precautions
Exclude malignancy if alarm symptoms present. Risk of Clostridium difficile-associated diarrhea, hypomagnesemia, and bone fractures with long-term use. Avoid use with clopidogrel.
Is Esomeprazole in shortage in Canada?
A Canadian shortage report is on file for a product containing this molecule: Active — reported by JAMP PHARMA CORPORATION, last seen 09 Sep 2026. A shortage on one presentation does not always affect every DIN of the molecule — the alternatives below list what else is marketed in Canada. Nexara can confirm current availability and identify substitutions or import options where permitted.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
26 of 46 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| APO-ESOMEPRAZOLE | 20 MG | TABLET (DELAYED-RELEASE) | APOTEX INC | MARKETED | 02339099 |
| APO-ESOMEPRAZOLE | 40 MG | TABLET (DELAYED-RELEASE) | APOTEX INC | MARKETED | 02339102 |
| ESOMEPRAZOLE | 20 MG | TABLET (DELAYED-RELEASE) | JAMP PHARMA CORPORATION | MARKETED | 02520699 |
| ESOMEPRAZOLE | 40 MG | TABLET (DELAYED-RELEASE) | JAMP PHARMA CORPORATION | MARKETED | 02520702 |
| ESOMEPRAZOLE | 40 MG | TABLET (DELAYED-RELEASE) | SIVEM PHARMACEUTICALS ULC | MARKETED | 02442507 |
| ESOMEPRAZOLE | 20 MG | TABLET (DELAYED-RELEASE) | PRO DOC LIMITEE | MARKETED | 02394839 |
| ESOMEPRAZOLE | 20 MG | TABLET (DELAYED-RELEASE) | SIVEM PHARMACEUTICALS ULC | MARKETED | 02442493 |
| ESOMEPRAZOLE | 40 MG | TABLET (DELAYED-RELEASE) | PRO DOC LIMITEE | MARKETED | 02394847 |
| M-ESOMEPRAZOLE | 20 MG | TABLET (DELAYED-RELEASE) | MANTRA PHARMA INC | MARKETED | 02520109 |
| M-ESOMEPRAZOLE | 40 MG | TABLET (DELAYED-RELEASE) | MANTRA PHARMA INC | MARKETED | 02520117 |
2 · Same class — other molecules in ATC A02BC
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Pantoprazole | ABBOTT-PANTOPRAZOLE · ACT PANTOPRAZOLE · AG-PANTOPRAZOLE · AG-PANTOPRAZOLE SODIUM · +37 more | 98 | 39 | Yes |
| Esomeprazole | APO-ESOMEPRAZOLE · APO-ESOMEPRAZOLE DELAYED-RELEASE · ESOMEPRAZOLE · ESOMEPRAZOLE DR · +14 more | 46 | 26 | Yes |
| Lansoprazole | APO-LANSOPRAZOLE · AVA-LANSOPRAZOLE · DOM-LANSOPRAZOLE · LANSOPRAZOLE · +15 more | 41 | 19 | Yes |
| Omeprazole | ACH-OMEPRAZOLE · AG-OMEPRAZOLE DR · AHI-OMEPRAZOLE · APO-OMEPRAZOLE · +31 more | 57 | 12 | Yes |
| Rabeprazole | ABBOTT-RABEPRAZOLE · AG-RABEPRAZOLE · APO-RABEPRAZOLE · DOM-RABEPRAZOLE EC · +15 more | 38 | 8 | Yes |
| Dexlansoprazole | APO-DEXLANSOPRAZOLE · DEXILANT · DEXLANSOPRAZOLE | 8 | 4 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC A02B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| A02BA | Cimetidine · Famotidine · Famotidine, Combinations · Nizatidine · Ranitidine · +1 more | 235 | 26 |
| A02BX | Alginic Acid · Pirenzepine · Sucralfate | 32 | 4 |
| A02BB | Misoprostol | 10 | 2 |
| A02BD | Bismuth Subcitrate,Tetracycline And Metronidazole · Lansoprazole, Amoxicillin And Clarithromycin | 3 | 2 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is NEXIUM - 40MG called?
The same molecule, Esomeprazole, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Nexium | Latin | Australia, Bahrain |
| APO-Esomeprazole | Latin | Australia |
| Esomeprazole GH | Latin | Australia |
| Esomeprazole GxP | Latin | Australia |
| Esomeprazole RBX | Latin | Australia |
| Esomeprazole Viatris | Latin | Australia |
| ESOMEPRAZOLE-WGR | Latin | Australia |
| Esopreze | Latin | Australia |
| Nexazole | Latin | Australia |
| Nexole | Latin | Australia |
| Noxicid Caps | Latin | Australia |
| ESOPOLE | Latin | Saudi Arabia |
| EMANERA | Latin | Czechia |
| GORDEX MUPS | Latin | Bahrain |
| HELIDES | Latin | Czechia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.