ONE-ALPHA 2 MCG — DIN 02240329
ALFACALCIDOL : 2 MCG · CHEPLAPHARM ARZNEIMITTEL GMBH · DROPS · wholesale supply in Canada
Health Canada status: MARKETED
What is ONE-ALPHA?
ONE-ALPHA 2 MCG contains ALFACALCIDOL : 2 MCG. It is listed in the Health Canada Drug Product Database under DIN 02240329, held by CHEPLAPHARM ARZNEIMITTEL GMBH, supplied as DROPS for ORAL administration. Health Canada currently lists it as marketed, status dated 31-Jan-2022. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is ONE-ALPHA used for?
ONE - ALPHA (alfacalcidol; capsules, oral drops, injection) is indicated in adult patients with chronic renal failure for: Management of hypocalcemia, Secondary hyperparathyroidism, Osteodystrophy.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Alfacalcidol cost around the world?
Alfacalcidol is listed on 12 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Austria publishes a KVP (Kassenverkaufspreis); Bahrain publishes a retail (max); Brazil publishes a preco fabrica (ex-factory ceiling). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Greece | producer price (ex-factory) | 12 | 12 | EUR███.██ |
| Romania | max producer price | 7 | 12 | RON███.██ |
| Saudi Arabia | public | 6 | 9 | SAR███.██ |
| South Africa | single exit price | 6 | 6 | ZAR███.██ |
| Czechia | max producer price (ex-factory) | 3 | 5 | CZK███.██ |
| Luxembourg | reimbursement | 4 | 4 | EUR███.██ |
| Morocco | PPV (public price) | 2 | 4 | MAD███.██ |
| United Kingdom | hospital | 3 | 3 | GBP███.██ |
| Austria | KVP (Kassenverkaufspreis) | 1 | 2 | EUR███.██ |
| Bahrain | retail (max) | 1 | 2 | BHD███.██ |
| Brazil | preco fabrica (ex-factory ceiling) | 1 | 2 | BRL███.██ |
| Spain | PVP con IVA (public price) | 1 | 1 | EUR███.██ |
62 pack listings across 47 brand entries and 12 price bases, refreshed 05 Sep 2026. Ranges span every Alfacalcidol pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Alfacalcidol in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
4 holders have a Canadian DIN containing Alfacalcidol, across 10 DINs, of which 6 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| CHEPLAPHARM ARZNEIMITTEL GMBH | 4 | 4 | ONE-ALPHA | Sourceable in Canada |
| SANDOZ CANADA INCORPORATED | 2 | 2 | SANDOZ ALFACALCIDOL | Sourceable in Canada |
| LEO PHARMA INC | 2 | 0 | ONE-ALPHA, ONE-ALPHA SOL 0.2MCG/ML | No marketed DIN |
| STRIDES PHARMA CANADA INC | 2 | 0 | ALFACALCIDOL CAPSULES | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 2 MCG |
|---|---|
| Dosage form | DROPS |
| Route | ORAL |
| Pack configuration (monograph) | Capsules 0.25 mcg: Available in tropical blisters of 100 (10x10 blisters). Capsules 1 mcg: Available in tropical blisters of 100 (10x10 blisters). Oral Drops 2 mcg/mL: Available in amber glass bottles of 10 mL and 20 mL fitted with a polyethylene dropping device. Injection 2 mcg/mL: Available in cartons of 10 ampoules. |
| Storage | Protect solution from direct sunlight (Oral Drops). Keep ampoules in outer carton to protect from light (Injection). |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation, because this listing covers more than one of them.
Substance and classification
| Active substance | Alfacalcidol |
|---|---|
| ATC code | A11CC03 |
| AHFS class | 84:92.00 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02240329 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2240329 |
| Brand name | ONE-ALPHA |
| Generic / active ingredient | ALFACALCIDOL : 2 MCG |
| Market authorization holder | CHEPLAPHARM ARZNEIMITTEL GMBH |
| Health Canada schedule | Prescription |
| ATC code | A11CC03 |
| ATC anatomical main group | A — Alimentary tract and metabolism |
| ATC therapeutic subgroup | A11CC |
| Current status | MARKETED |
| Status date | 31-Jan-2022 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
6 of 10 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| ONE-ALPHA | 0.25 MCG | CAPSULE | CHEPLAPHARM ARZNEIMITTEL GMBH | MARKETED | 00474517 |
| ONE-ALPHA | 1 MCG | CAPSULE | CHEPLAPHARM ARZNEIMITTEL GMBH | MARKETED | 00474525 |
| ONE-ALPHA | 2 MCG | SOLUTION | CHEPLAPHARM ARZNEIMITTEL GMBH | MARKETED | 02242502 |
| SANDOZ ALFACALCIDOL | 1 MCG | CAPSULE | SANDOZ CANADA INCORPORATED | MARKETED | 02533324 |
| SANDOZ ALFACALCIDOL | 0.25 MCG | CAPSULE | SANDOZ CANADA INCORPORATED | MARKETED | 02533316 |
| ALFACALCIDOL CAPSULES | 0.25 MCG | CAPSULE | STRIDES PHARMA CANADA INC | APPROVED | 02523051 |
| ALFACALCIDOL CAPSULES | 1 MCG | CAPSULE | STRIDES PHARMA CANADA INC | APPROVED | 02523078 |
| ONE-ALPHA | 0.5 MCG | CAPSULE | LEO PHARMA INC | CANCELLED PRE MARKET | 02239431 |
| ONE-ALPHA SOL 0.2MCG/ML | .2 MCG | LIQUID | LEO PHARMA INC | CANCELLED POST MARKET | 00759546 |
2 · Same class — other molecules in ATC A11CC
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Colecalciferol | AG-VITAMINE D · AG-VITAMINE D TABLETS · D CAPS 400 UNITS · D VI SOL INFANTS DROPS 400UNIT/0.6ML · +24 more | 39 | 12 | Yes |
| Calcitriol | CALCIJEX · CALCITRIOL INJECTION · CALCITRIOL INJECTION USP · CALCITRIOL-ODAN · +4 more | 14 | 6 | Yes |
| Alfacalcidol | ALFACALCIDOL CAPSULES · ONE-ALPHA · ONE-ALPHA SOL 0.2MCG/ML · SANDOZ ALFACALCIDOL | 10 | 6 | Yes |
| Vitamin D And Analogues | RADIOSTOL SOLUTION 100000IU/ML · THERAPLEX D TAB 250UNIT · VITAMIN D · VITAMIN D TAB 1000UNIT · +2 more | 7 | 0 | Not in Canada |
| Ergocalciferol | D-FORTE · OSTO-D2 · OSTOFORTE · RADIOSTOL CAP 50000IU · +2 more | 6 | 0 | Not in Canada |
| Calcifediol | RAYALDEE | 1 | 0 | Not in Canada |
| Dihydrotachysterol | HYTAKEROL | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC A11C
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| A11CA | Beta-Carotene · Retinol (Vit A) | 108 | 0 |
| A11CB | Vitamin A And D In Combination | 75 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is ONE-ALPHA called?
The same molecule, Alfacalcidol, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Alfa Di | Latin | Saudi Arabia |
| Alfacalcidol | Latin | Saudi Arabia |
| ALFACALCIDOL CANDE | Latin | Czechia |
| OSTEO-ALFA | Latin | Bahrain |
| SIGMACALCIDOL | Latin | Brazil |
| ENZOLA | Latin | Czechia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.