METHYL-PLEX 400 MCG — DIN 02238287
VITAMIN B12 (CYANOCOBALAMIN) : 400 MCG VITAMIN B6 (PYRIDOXAL-5-PHOSPHATE) : 10 MG FOLIC ACID : 0.4 MG · THORNE RESEARCH INC. · CAPSULE · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is METHYL-PLEX?
METHYL-PLEX 400 MCG contains VITAMIN B12 (CYANOCOBALAMIN) : 400 MCG VITAMIN B6 (PYRIDOXAL-5-PHOSPHATE) : 10 MG FOLIC ACID : 0.4 MG. It is listed in the Health Canada Drug Product Database under DIN 02238287, held by THORNE RESEARCH INC., supplied as CAPSULE for ORAL administration. Health Canada currently lists it as cancelled post market, status dated 26-Aug-2005. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
How much does Folic Acid, Combinations cost around the world?
Folic Acid, Combinations is listed on 9 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Bahrain publishes a retail (max); Greece publishes a producer price (ex-factory). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 1 | 24 | USD███.██ |
| Saudi Arabia | public | 14 | 20 | SAR███.██ |
| Bahrain | retail (max) | 5 | 11 | BHD███.██ |
| United Arab Emirates | public | 5 | 10 | AED███.██ |
| Greece | producer price (ex-factory) | 7 | 7 | EUR███.██ |
| Australia | ex-manufacturer | 3 | 6 | AUD███.██ |
| South Africa | single exit price | 2 | 6 | ZAR███.██ |
| United Kingdom | hospital | 2 | 2 | GBP███.██ |
| Iceland | max wholesale | 1 | 1 | ISK███.██ |
87 pack listings across 40 brand entries and 8 price bases, refreshed 08 Sep 2026. Ranges span every Folic Acid, Combinations pack in that market, so a high figure is usually a larger pack rather than the same product.
This table is a regulatory record of where the molecule is listed. The DIN on this page is no longer authorized for sale in Canada, so Nexara does not quote it — see the alternatives above.
Is there a generic Folic Acid, Combinations in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
6 holders have a Canadian DIN containing Folic Acid, Combinations, across 6 DINs, of which 0 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| GAHLER ENTERPRISES LTD. | 1 | 0 | FOLIC ACID 1MG WITH C 20MG | No marketed DIN |
| HOLISTA HEALTH (CANADA) INC. 2000 Brigantine Dirve Coquitlam British Columbia Canada V3K 7B5 | 1 | 0 | FOLIC ACID & VITAMIN C | No marketed DIN |
| NU-LIFE NUTRITION LTD. | 1 | 0 | FOLIC ACID TAB 5MG NU LIFE | No marketed DIN |
| THORNE RESEARCH INC. | 1 | 0 | METHYL-PLEX | No marketed DIN |
| WAMPOLE BRANDS | 1 | 0 | B6, B12 & FOLIC ACID MULTI-VITAMIN TABLETS | No marketed DIN |
| WN PHARMACEUTICALS LTD. | 1 | 0 | FOLIC ACID 1MG WITH VITAMIN C | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 400 MCG |
|---|---|
| Dosage form | CAPSULE |
| Route | ORAL |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Folic Acid, Combinations |
|---|---|
| ATC code | B03BB51 |
| AHFS class | 88:08.00 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02238287 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2238287 |
| Brand name | METHYL-PLEX |
| Generic / active ingredient | VITAMIN B12 (CYANOCOBALAMIN) : 400 MCG VITAMIN B6 (PYRIDOXAL-5-PHOSPHATE) : 10 MG FOLIC ACID : 0.4 MG |
| Market authorization holder | THORNE RESEARCH INC. |
| Health Canada schedule | NON-PRESCRIPTION DRUGS |
| ATC code | B03BB51 |
| ATC anatomical main group | B — Blood and blood-forming organs |
| ATC therapeutic subgroup | B03BB |
| Current status | CANCELLED POST MARKET |
| Status date | 26-Aug-2005 |
| Original market date | 1998-09-01 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
0 of 6 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| B6, B12 & FOLIC ACID MULTI-VITAMIN TABLETS | 1 MG | TABLET | WAMPOLE BRANDS | CANCELLED POST MARKET | 02240366 |
| FOLIC ACID & VITAMIN C | Strength | Tablet | HOLISTA HEALTH (CANADA) INC. 2000 Brigantine Dirve Coquitlam British Columbia Canada V3K 7B5 | CANCELLED POST MARKET | 02246273 |
| FOLIC ACID 1MG WITH C 20MG | 1 MG | TABLET | GAHLER ENTERPRISES LTD. | CANCELLED POST MARKET | 00700517 |
| FOLIC ACID 1MG WITH VITAMIN C | 20 MG | TABLET | WN PHARMACEUTICALS LTD. | CANCELLED POST MARKET | 02231739 |
| FOLIC ACID TAB 5MG NU LIFE | 450 MG | TABLET | NU-LIFE NUTRITION LTD. | CANCELLED POST MARKET | 00064475 |
2 · Same class — other molecules in ATC B03BB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Folic Acid | ACIDE FOLIQUE 5 TAB · FOLIC ACID · FOLIC ACID (1MG TABLET) · FOLIC ACID 0.4 MG TABLET · +27 more | 37 | 3 | Yes |
| Folic Acid, Combinations | B6, B12 & FOLIC ACID MULTI-VITAMIN TABLETS · FOLIC ACID & VITAMIN C · FOLIC ACID 1MG WITH C 20MG · FOLIC ACID 1MG WITH VITAMIN C · +2 more | 6 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC B03B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| B03BA | Cobamamide · Cobamamide, Combinations · Cyanocobalamin · Cyanocobalamin, Combinations · Hydroxocobalamin · +2 more | 85 | 4 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is METHYL-PLEX called?
The same molecule, Folic Acid, Combinations, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Folic Acid | Latin | Bahrain, Saudi Arabia |
| FOLITAB | Latin | Bahrain |
| FOLICUM | Latin | Bahrain, Saudi Arabia |
| AKFOLIC | Latin | Bahrain |
| FEROSE ® - F | Latin | United Arab Emirates |
| FOLIVITA TAB | Latin | Saudi Arabia |
| JORIVER FOLIC ACID | Latin | Bahrain |
| Metafolin | Latin | Iceland |
| TRI-B | Latin | Saudi Arabia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.