PMS-IPRATROPIUM 250 MCG — DIN 02231136
IPRATROPIUM BROMIDE : 250 MCG · PHARMASCIENCE INC · SOLUTION · wholesale supply in Canada
Health Canada status: DORMANT
What is PMS-IPRATROPIUM?
PMS-IPRATROPIUM 250 MCG contains IPRATROPIUM BROMIDE : 250 MCG. It is listed in the Health Canada Drug Product Database under DIN 02231136, held by PHARMASCIENCE INC, supplied as SOLUTION for INHALATION administration. Health Canada currently lists it as dormant, status dated 01-Aug-2025. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A). This DIN is not currently being marketed in Canada, so it is sourced to order where a compliant route exists rather than held in stock.
What is PMS-IPRATROPIUM used for?
pms-IPRATROPIUM (ipratropium bromide) nebulizer solution is indicated for: the treatment of bronchospasm associated with acute exacerbations of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema; the treatment of bronchospasm associated with acute severe exacerbations of bronchial asthma when used in conjunction with a beta 2 adrenergic agonist such as salbutamol.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Ipratropium Bromide cost around the world?
Ipratropium Bromide is listed on 5 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Belgium publishes a public; Greece publishes a producer price (ex-factory). Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Sweden | AIP (pharmacy purchase price) | 8 | 12 | SEK███.██ |
| Greece | producer price (ex-factory) | 6 | 6 | EUR███.██ |
| Belgium | public | 5 | 5 | EUR███.██ |
| Australia | ex-manufacturer | 3 | 4 | AUD███.██ |
| Morocco | PPV (public price) | 1 | 4 | MAD███.██ |
31 pack listings across 23 brand entries and 5 price bases, refreshed 08 Sep 2026. Ranges span every Ipratropium Bromide pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Ipratropium Bromide in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
13 holders have a Canadian DIN containing Ipratropium Bromide, across 30 DINs, of which 8 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| PHARMASCIENCE INC | 5 | 4 | PMS-IPRATROPIUM | Sourceable in Canada |
| BOEHRINGER INGELHEIM (CANADA) LTD LTEE | 5 | 1 | ATROVENT, ATROVENT HFA, ATROVENT NASAL AEROSOL 20MCG/AEM, ATROVENT UDV 125MCG/ML, ATROVENT UDV SOL INH 250MCG/ML | Sourceable in Canada |
| TEVA CANADA LIMITED | 3 | 1 | RATIO-IPRATROPIUM UDV, TEVA-IPRATROPIUM STERINEBS | Sourceable in Canada |
| AA PHARMA INC | 1 | 1 | AA-IPRAVENT | Sourceable in Canada |
| JAMP PHARMA CORPORATION | 1 | 1 | JAMP IPRATROPIUM HFA | Sourceable in Canada |
| DOMINION PHARMACAL | 4 | 0 | DOM-IPRATROPIUM 125 MCG/ML, DOM-IPRATROPIUM 250 MCG/ML (1 ML), DOM-IPRATROPIUM 250 MCG/ML (2 ML), DOM-IPRATROPIUM 250 MCG/ML (20 ML) | No marketed DIN |
| PHARMEL INC | 4 | 0 | PHL-IPRATROPIUM, PHL-IPRATROPIUM - 1ML POLYNEB, PHL-IPRATROPIUM - 20ML, PHL-IPRATROPIUM - 2ML POLYNEB | No marketed DIN |
| APOTEX INC | 2 | 0 | APO-IPRAVENT STERULES | No marketed DIN |
| NOVOPHARM LIMITED | 1 | 0 | NOVO-IPRAMIDE - LIQ 0.25MG/ML | No marketed DIN |
| NU-PHARM INC | 1 | 0 | NU-IPRATROPIUM PLASTIC AMPULES 250 MCG/ML | No marketed DIN |
| PENTAPHARM LTD. | 1 | 0 | PENTA-IPRATROPIUM BROMIDE | No marketed DIN |
| RATIOPHARM INC DIVISION OF TEVA CANADA LIMITED | 1 | 0 | RATIO-IPRATROPIUM INHALATION SOLUTION | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 250 MCG |
|---|---|
| Dosage form | SOLUTION |
| Route | INHALATION |
| Pack configuration (monograph) | 20 mL Bottles |
| Storage | Unopened bottles should be stored at controlled room temperature (between 15°C and 30°C). Solutions diluted with preservative free sterile Sodium Chloride Inhalation Solution, USP 0.9% should be used within 24 hours from time of dilution when stored at room temperature and within 48 hours when stored in the refrigerator. Opened and closed bottles were stable for up to 28 days when stored at room temperature (15º - 30ºC). |
| Shipping class | Cold chain — validated shipper with temperature monitoring |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Cold chain. This product is stored refrigerated. Nexara ships it on a validated cold chain with temperature monitoring; a delivery address that cannot receive and store it at 2–8 °C on arrival must be flagged before the order is placed.
Substance and classification
| Active substance | Ipratropium Bromide |
|---|---|
| ATC code | R03BB01 |
| AHFS class | 12:08.08 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02231136 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2231136 |
| Brand name | PMS-IPRATROPIUM |
| Generic / active ingredient | IPRATROPIUM BROMIDE : 250 MCG |
| Market authorization holder | PHARMASCIENCE INC |
| Health Canada schedule | Prescription |
| ATC code | R03BB01 |
| ATC anatomical main group | R — Respiratory system |
| ATC therapeutic subgroup | R03BB |
| Current status | DORMANT |
| Status date | 01-Aug-2025 |
| Original market date | 1997-07-15 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
8 of 30 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| AA-IPRAVENT | 250 MCG | SOLUTION | AA PHARMA INC | MARKETED | 02126222 |
| ATROVENT HFA | 20 MCG | METERED-DOSE AEROSOL | BOEHRINGER INGELHEIM (CANADA) LTD LTEE | MARKETED | 02247686 |
| JAMP IPRATROPIUM HFA | 20 MCG | METERED-DOSE AEROSOL | JAMP PHARMA CORPORATION | MARKETED | 02542587 |
| PMS-IPRATROPIUM | 250 MCG | SOLUTION | PHARMASCIENCE INC | MARKETED | 02231244 |
| PMS-IPRATROPIUM | 21 MCG | SOLUTION | PHARMASCIENCE INC | MARKETED | 02239627 |
| PMS-IPRATROPIUM | 125 MCG | SOLUTION | PHARMASCIENCE INC | MARKETED | 02231135 |
| PMS-IPRATROPIUM | 250 MCG | SOLUTION | PHARMASCIENCE INC | MARKETED | 02231245 |
| TEVA-IPRATROPIUM STERINEBS | 250 MCG | SOLUTION | TEVA CANADA LIMITED | MARKETED | 02216221 |
| APO-IPRAVENT STERULES | 125 MCG | SOLUTION | APOTEX INC | CANCELLED POST MARKET | 02243827 |
| APO-IPRAVENT STERULES | 250 MCG | SOLUTION | APOTEX INC | CANCELLED POST MARKET | 02231494 |
2 · Same class — other molecules in ATC R03BB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Ipratropium Bromide | AA-IPRAVENT · APO-IPRAVENT STERULES · ATROVENT · ATROVENT HFA · +20 more | 30 | 8 | Yes |
| Tiotropium Bromide | APO-TIOTROPIUM · LUPIN-TIOTROPIUM · SPIRIVA · SPIRIVA RESPIMAT | 4 | 4 | Yes |
| Aclidinium Bromide | TUDORZA GENUAIR | 1 | 1 | Yes |
| Glycopyrronium Bromide | SEEBRI BREEZHALER | 1 | 1 | Yes |
| Umeclidinium Bromide | INCRUSE ELLIPTA | 1 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC R03B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| R03BA | Beclometasone · Budesonide · Ciclesonide · Flunisolide · Fluticasone · +3 more | 66 | 33 |
| R03BC | Cromoglicic Acid · Nedocromil | 11 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is PMS-IPRATROPIUM called?
The same molecule, Ipratropium Bromide, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Atrovent | Latin | Australia, Morocco, Sweden |
| Atrovent® | Latin | Sweden |
| Atrovent Adult | Latin | Australia |
| Cipla Ipratropium | Latin | Australia |
| Combivent® | Latin | Sweden |
| Ipratropium/Salbutamol Orion | Latin | Sweden |
| Ipravent | Latin | Sweden |
| Ipraxa | Latin | Sweden |
| Salipra | Latin | Sweden |
| Sapimol | Latin | Sweden |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
What is Ipratropium Bromide called in other languages?
Buyers, prescribers and procurement teams outside Canada often search for the ingredient in their own script. These are phonetic renderings of the ingredient name Ipratropium Bromide, published to help those searches reach this page.
| Language | Ipratropium Bromide |
|---|---|
| Spanish Español | Bromuro de ipratropio |
| French Français | Bromure d'ipratropium |
| Portuguese Português | Brometo de ipratrópio |
| German Deutsch | Ipratropiumbromid |
| Japanese 日本語 | イプラトロピウム臭化物 |
These are transliterations of the ingredient name, generated automatically and published only where two independent checks agreed. They are not registered local trade names and carry no marketing authorisation in any market. Always confirm a product against its local registration before ordering.
How can I get it?
This DIN is dormant — it holds a Health Canada authorization but is not currently being marketed in Canada, so it cannot simply be ordered from Canadian stock. Where a patient need exists, supply may be possible through exceptional importation or the Special Access Programme, subject to Health Canada's requirements and the prescriber's application. Nexara can advise on the route and on marketed alternatives.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.