APO-DOXEPIN 50 MG — DIN 02050013
DOXEPIN (DOXEPIN HYDROCHLORIDE) : 50 MG · AA PHARMA INC · CAPSULE · wholesale supply in Canada
Health Canada status: MARKETED
What is APO-DOXEPIN?
APO-DOXEPIN 50 MG contains DOXEPIN (DOXEPIN HYDROCHLORIDE) : 50 MG. It is listed in the Health Canada Drug Product Database under DIN 02050013, held by AA PHARMA INC, supplied as CAPSULE for ORAL administration. Health Canada currently lists it as marketed, status dated 13-Nov-2025. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A) and can source this product for hospitals, pharmacies and clinics. Availability and lead time are confirmed per order.
What is APO-DOXEPIN used for?
The antidepressant and anxiolytic properties of APO-DOXEPIN (doxepin hydrochloride) have been found to be of value in the drug treatment of: Psychoneurotic patients with anxiety and/or depressive reactions (Anxiety neurosis associated with somatic disorders, Alcoholic patients with anxiety and/or depression); Psychotic depression, including manic-depressive illness (depressed type) and involutional melancholia.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
How much does Doxepin cost around the world?
Doxepin is listed on 4 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Lebanon publishes a public price (USD, Decision 119/1); Romania publishes a max producer price; United Kingdom publishes a hospital. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 10 | 118 | USD███.██ |
| United Kingdom | hospital | 2 | 2 | GBP███.██ |
| Lebanon | public price (USD, Decision 119/1) | 1 | 2 | USD███.██ |
| Romania | max producer price | 1 | 1 | RON███.██ |
123 pack listings across 14 brand entries and 4 price bases, refreshed 03 Sep 2026. Ranges span every Doxepin pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Doxepin in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
11 holders have a Canadian DIN containing Doxepin, across 51 DINs, of which 22 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| AA PHARMA INC | 6 | 6 | APO-DOXEPIN, SINEQUAN | Sourceable in Canada |
| JAMP PHARMA CORPORATION | 5 | 5 | JAMP DOXEPIN | Sourceable in Canada |
| MARCAN PHARMACEUTICALS INC | 5 | 5 | MAR-DOXEPIN | Sourceable in Canada |
| APOTEX INC | 5 | 4 | APO-DOXEPIN | Sourceable in Canada |
| KNIGHT THERAPEUTICS INC. | 2 | 2 | SILENOR | Sourceable in Canada |
| TEVA CANADA LIMITED | 9 | 0 | NOVO-DOXEPIN, NTP-DOXEPIN | No marketed DIN |
| PRO DOC LIMITEE | 6 | 0 | DOXEPINE-10 - CAP, DOXEPINE-100 - CAP, DOXEPINE-150 - CAP, DOXEPINE-25 -CAP, DOXEPINE-50 - CAP, +1 more | No marketed DIN |
| AVENTIS PHARMA INC | 5 | 0 | TRIADAPIN CAP 100MG, TRIADAPIN CAP 10MG, TRIADAPIN CAP 25MG, TRIADAPIN CAP 50MG, TRIADAPIN CAP 75MG | No marketed DIN |
| ALTIMED PHARMA INC. | 4 | 0 | ALTI-DOXEPIN - CAP 10MG, ALTI-DOXEPIN-CAP 25MG, ALTI-DOXEPIN-CAP 50MG, ALTI-DOXEPIN-CAP 75MG | No marketed DIN |
| RHODIAPHARM INC | 3 | 0 | RHO-DOXEPIN - CAP 25MG, RHO-DOXEPIN - CAP 50MG, RHO-DOXEPIN-10 MG CAP | No marketed DIN |
| PFIZER CANADA ULC | 1 | 0 | SINEQUAN CAP 150MG | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 50 MG |
|---|---|
| Dosage form | CAPSULE |
| Route | ORAL |
| Pack configuration (monograph) | Bottles of 100 |
| Storage | Store at room temperature 15°C to 30°C. |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Doxepin |
|---|---|
| ATC code | N06AA12 |
| AHFS class | 28:16.04.28 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02050013 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2050013 |
| Brand name | APO-DOXEPIN |
| Generic / active ingredient | DOXEPIN (DOXEPIN HYDROCHLORIDE) : 50 MG |
| Market authorization holder | AA PHARMA INC |
| Health Canada schedule | Prescription |
| ATC code | N06AA12 |
| ATC anatomical main group | N — Nervous system |
| ATC therapeutic subgroup | N06AA |
| Current status | MARKETED |
| Status date | 13-Nov-2025 |
| Original market date | 1993-12-31 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
22 of 51 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| APO-DOXEPIN | 10 MG | CAPSULE | APOTEX INC | MARKETED | 02049996 |
| APO-DOXEPIN | 100 MG | CAPSULE | APOTEX INC | MARKETED | 02050048 |
| APO-DOXEPIN | 25 MG | CAPSULE | APOTEX INC | MARKETED | 02050005 |
| APO-DOXEPIN | 75 MG | CAPSULE | APOTEX INC | MARKETED | 02050021 |
| JAMP DOXEPIN | 100 MG | CAPSULE | JAMP PHARMA CORPORATION | MARKETED | 02559293 |
| JAMP DOXEPIN | 75 MG | CAPSULE | JAMP PHARMA CORPORATION | MARKETED | 02559285 |
| JAMP DOXEPIN | 25 MG | CAPSULE | JAMP PHARMA CORPORATION | MARKETED | 02559269 |
| JAMP DOXEPIN | 10 MG | CAPSULE | JAMP PHARMA CORPORATION | MARKETED | 02559250 |
| JAMP DOXEPIN | 50 MG | CAPSULE | JAMP PHARMA CORPORATION | MARKETED | 02559277 |
| MAR-DOXEPIN | 25 MG | CAPSULE | MARCAN PHARMACEUTICALS INC | MARKETED | 02559099 |
2 · Same class — other molecules in ATC N06AA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Doxepin | ALTI-DOXEPIN - CAP 10MG · ALTI-DOXEPIN-CAP 25MG · ALTI-DOXEPIN-CAP 50MG · ALTI-DOXEPIN-CAP 75MG · +22 more | 51 | 22 | Yes |
| Amitriptyline | AG-AMITRIPTYLINE · AMITRIPTYLINE · AMITRIPTYLINE 10 TAB · AMITRIPTYLINE 25 TAB · +28 more | 83 | 15 | Yes |
| Imipramine | APO-IMIPRAMINE · APO-IMIPRAMINE TABLETS · IMIPRAMINE 10TAB · IMIPRAMINE 25TAB · +16 more | 32 | 8 | Yes |
| Desipramine | DESIPRAMINE · DESIPRAMINE-10 - TAB 10MG · DESIPRAMINE-25 - TAB 25MG · DESIPRAMINE-50 - TAB 50MG · +29 more | 49 | 5 | Yes |
| Clomipramine | ACT CLOMIPRAMINE · ALTIUS-CLOMIPRAMINE · ANAFRANIL · APO-CLOMIPRAMINE · +19 more | 35 | 5 | Yes |
| Trimipramine | APO-TRIMIPRAMINE · NOVO-TRIPRAMINE TAB 100MG BP · NOVO-TRIPRAMINE TAB 25MG BP · NOVO-TRIPRAMINE TAB 50MG BP · +15 more | 32 | 5 | Yes |
| Nortriptyline | APO-NORTRIPTYLINE · AVA-NORTRIPTYLINE · AVENTYL · DOM-NORTRIPTYLINE 10MG CAPSULES · +10 more | 24 | 2 | Yes |
| Maprotiline | LUDIOMIL TAB 10MG · LUDIOMIL TAB 25MG · LUDIOMIL TAB 50MG · LUDIOMIL TAB 75MG · +3 more | 12 | 0 | Not in Canada |
| Amoxapine | ASENDIN - TAB 100MG · ASENDIN - TAB 25MG · ASENDIN - TAB 50MG · ASENDIN TAB 100MG · +2 more | 6 | 0 | Not in Canada |
| Protriptyline | TRIPTIL TAB 10MG | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC N06A
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| N06AB | Citalopram · Escitalopram · Fluoxetine · Fluvoxamine · Paroxetine · +1 more | 589 | 248 |
| N06AX | Bupropion · Desvenlafaxine · Duloxetine · Esketamine · Levomilnacipran · +7 more | 386 | 181 |
| N06AG | Moclobemide | 21 | 4 |
| N06AF | Tranylcypromine | 2 | 2 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is APO-DOXEPIN called?
The same molecule, Doxepin, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| DOXEPIN HCl | Latin | Lebanon |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
Nexara Health supplies this product to licensed Canadian buyers — pharmacies, hospitals, clinics, licensed distributors, and clinical trial sponsors or their CROs. We confirm stock, pack size, expiry and pricing at the time of quotation. If the product is on backorder or in shortage, we identify equivalent alternatives and import options where permitted.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.