APO-TIMOP 0.25 % — DIN 00755826
TIMOLOL (TIMOLOL MALEATE) : 0.25 % · APOTEX INC · SOLUTION · wholesale supply in Canada
Health Canada status: DORMANT
What is APO-TIMOP?
APO-TIMOP 0.25 % contains TIMOLOL (TIMOLOL MALEATE) : 0.25 %. It is listed in the Health Canada Drug Product Database under DIN 00755826, held by APOTEX INC, supplied as SOLUTION for OPHTHALMIC administration. Health Canada currently lists it as dormant, status dated 04-Aug-2017. Nexara Health is a licensed Canadian wholesale distributor (DEL 3-002896-A). This DIN is not currently being marketed in Canada, so it is sourced to order where a compliant route exists rather than held in stock.
How much does Timolol cost around the world?
Timolol is listed on 14 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Australia publishes a ex-manufacturer; Austria publishes a KVP (Kassenverkaufspreis); Belgium publishes a public. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| United States | acquisition | 8 | 62 | USD███.██ |
| Czechia | max producer price (ex-factory) | 28 | 45 | CZK███.██ |
| Slovakia | categorised final price | 14 | 23 | EUR███.██ |
| Austria | KVP (Kassenverkaufspreis) | 22 | 22 | EUR███.██ |
| Belgium | public | 18 | 18 | EUR███.██ |
| Luxembourg | reimbursement | 17 | 17 | EUR███.██ |
| Morocco | PPV (public price) | 8 | 17 | MAD███.██ |
| Australia | ex-manufacturer | 3 | 9 | AUD███.██ |
| South Africa | single exit price | 8 | 8 | ZAR███.██ |
| Greece | producer price (ex-factory) | 7 | 7 | EUR███.██ |
| United Kingdom | hospital | 5 | 5 | GBP███.██ |
| Spain | PVP con IVA (public price) | 4 | 4 | EUR███.██ |
| Romania | max producer price | 4 | 4 | RON███.██ |
| Hungary | producer price (ex-factory) | 2 | 2 | HUF███.██ |
243 pack listings across 148 brand entries and 13 price bases, refreshed 08 Sep 2026. Ranges span every Timolol pack in that market, so a high figure is usually a larger pack rather than the same product.
Canada publishes no comparable public list price. For a delivered Canadian price on a licensed account, verify your licence — it takes about a minute.
Is there a generic Timolol in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
16 holders have a Canadian DIN containing Timolol, across 35 DINs, of which 7 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| SANDOZ CANADA INCORPORATED | 6 | 4 | SANDOZ TIMOLOL, T-LO, TIMOLOL MALEATE-EX | Sourceable in Canada |
| ELVIUM LIFE SCIENCES | 2 | 2 | TIMOPTIC, TIMOPTIC-XE | Sourceable in Canada |
| JAMP PHARMA CORPORATION | 1 | 1 | JAMP-TIMOLOL | Sourceable in Canada |
| APOTEX INC | 4 | 0 | APO-TIMOP, APO-TIMOP GEL | No marketed DIN |
| BDH INC. | 2 | 0 | TIMOLOL SOLUTION - 0.25%, TIMOLOL SOLUTION - 0.5% | No marketed DIN |
| CIBA VISION CANADA INC | 2 | 0 | BETA-TIM - 0.25% LIQ, BETA-TIM - 0.5% LIQ | No marketed DIN |
| DOMINION PHARMACAL | 2 | 0 | DOM-TIMOLOL | No marketed DIN |
| MEDICAN PHARMA INCORPORATED | 2 | 0 | MED TIMOLOL LIQ OPH 0.25%, MED TIMOLOL LIQ OPH 0.5% | No marketed DIN |
| MYLAN PHARMACEUTICALS ULC | 2 | 0 | MYLAN-TIMOLOL | No marketed DIN |
| NOVOPHARM LIMITED | 2 | 0 | NOVO-TIMOL LIQ 0.25%, NOVO-TIMOL LIQ 0.5% | No marketed DIN |
| ODAN LABORATORIES LTD | 2 | 0 | ODAN-TIMOLOL | No marketed DIN |
| RHOXALPHARMA INC | 2 | 0 | RHOXAL-TIMOLOL 0.25%, RHOXAL-TIMOLOL 0.5% | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 0.25 % |
|---|---|
| Dosage form | SOLUTION |
| Route | OPHTHALMIC |
Before an order line is unambiguous Nexara needs the strength, the pack size and the presentation.
Substance and classification
| Active substance | Timolol |
|---|---|
| ATC code | S01ED01 |
| AHFS class | 52:40.08 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 00755826 |
|---|---|
| DIN (unpadded, as printed on some documents) | 755826 |
| Brand name | APO-TIMOP |
| Generic / active ingredient | TIMOLOL (TIMOLOL MALEATE) : 0.25 % |
| Market authorization holder | APOTEX INC |
| Health Canada schedule | Prescription |
| ATC code | S01ED01 |
| ATC anatomical main group | S — Sensory organs |
| ATC therapeutic subgroup | S01ED |
| Current status | DORMANT |
| Status date | 04-Aug-2017 |
| Original market date | 1988-12-31 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
Is Timolol in shortage in Canada?
A Canadian shortage report is on file for a product containing this molecule: Active — reported by SANDOZ CANADA INCORPORATED, last seen 09 Sep 2026. A shortage on one presentation does not always affect every DIN of the molecule — the alternatives below list what else is marketed in Canada. Nexara can confirm current availability and identify substitutions or import options where permitted.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
7 of 35 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| JAMP-TIMOLOL | 0.5 % | SOLUTION | JAMP PHARMA CORPORATION | MARKETED | 02447800 |
| SANDOZ TIMOLOL | 0.5 % | SOLUTION | SANDOZ CANADA INCORPORATED | MARKETED | 02166720 |
| SANDOZ TIMOLOL | 0.25 % | SOLUTION | SANDOZ CANADA INCORPORATED | MARKETED | 02166712 |
| TIMOLOL MALEATE-EX | 0.5 % | SOLUTION (EXTENDED RELEASE) | SANDOZ CANADA INCORPORATED | MARKETED | 02242276 |
| TIMOLOL MALEATE-EX | 0.25 % | SOLUTION (EXTENDED RELEASE) | SANDOZ CANADA INCORPORATED | MARKETED | 02242275 |
| TIMOPTIC | 0.5 % | SOLUTION | ELVIUM LIFE SCIENCES | MARKETED | 00451207 |
| TIMOPTIC-XE | 0.5 % | SOLUTION (EXTENDED RELEASE) | ELVIUM LIFE SCIENCES | MARKETED | 02171899 |
| APO-TIMOP | 0.5 % | SOLUTION | APOTEX INC | DORMANT | 00755834 |
| APO-TIMOP GEL | 0.25 % | SOLUTION (EXTENDED RELEASE) | APOTEX INC | APPROVED | 02315858 |
| APO-TIMOP GEL | 0.5 % | SOLUTION (EXTENDED RELEASE) | APOTEX INC | DORMANT | 02290812 |
2 · Same class — other molecules in ATC S01ED
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Timolol, Combinations | ACT DORZOTIMOLOL · AG-DORZOLAMIDE TIMOLOL · APO-BRIMONIDINE-TIMOP · APO-DORZO-TIMOP · +43 more | 50 | 21 | Yes |
| Timolol | APO-TIMOP · APO-TIMOP GEL · BETA-TIM - 0.25% LIQ · BETA-TIM - 0.5% LIQ · +20 more | 35 | 7 | Yes |
| Levobunolol | APO-LEVOBUNOLOL OPHTHALMIC SOLUTION USP 0.25% · APO-LEVOBUNOLOL OPHTHALMIC SOLUTION USP 0.5% · BETAGAN 0.5% OPHTHALMIC SOL · BETAGAN OPH SOLN 0.25% · +6 more | 16 | 0 | Not in Canada |
| Betaxolol | BETOPTIC LIQ · BETOPTIC S · NOVO-BETAXOLOL · SANDOZ BETAXOLOL | 4 | 0 | Not in Canada |
| Betaxolol, Combinations | BETOPTIC/PILO | 1 | 0 | Not in Canada |
| Levobunolol, Combinations | PROBETA - LIQ OPH | 1 | 0 | Not in Canada |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC S01E
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| S01EE | Bimatoprost · Latanoprost · Latanoprostene Bunod · Tafluprost · Travoprost · +1 more | 40 | 19 |
| S01EA | Apraclonidine · Brimonidine · Dipivefrine · Epinephrine | 28 | 10 |
| S01EC | Acetazolamide · Brinzolamide · Brinzolamide, Combinations · Dorzolamide · Methazolamide | 32 | 8 |
| S01EB | Acetylcholine · Carbachol · Ecothiopate · Pilocarpine · Pilocarpine, Combinations | 65 | 4 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is APO-TIMOP called?
The same molecule, Timolol, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Timoptol | Latin | Australia, Morocco |
| XALACOM | Latin | Czechia, Slovakia |
| Brinzolamid/timolol Olikla | Latin | Czechia, Slovakia |
| CUSIMOLOL | Latin | Morocco |
| FIXAPOST | Latin | Czechia |
| TIMOEYE | Latin | Australia |
| Timoptol XE | Latin | Australia |
| AKISTAN DUO | Latin | Czechia |
| AZARGA | Latin | Czechia |
| BIMATOPROST/TIMOLOL OLIKLA | Latin | Czechia |
| BRIMONIDIN/TIMOLOL OLIKLA | Latin | Czechia |
| COMBIGAN | Latin | Czechia, Slovakia |
| COSOPT | Latin | Czechia |
| COSOPT BEZ KONZERVA�N�CH P��SAD | Latin | Czechia |
| DORZOGEN COMBI | Latin | Czechia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
How can I get it?
This DIN is dormant — it holds a Health Canada authorization but is not currently being marketed in Canada, so it cannot simply be ordered from Canadian stock. Where a patient need exists, supply may be possible through exceptional importation or the Special Access Programme, subject to Health Canada's requirements and the prescriber's application. Nexara can advise on the route and on marketed alternatives.
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.