CALDOMINE DH ENFANT 12.5 MG / 5 ML — DIN 00550493
PHENYLPROPANOLAMINE HYDROCHLORIDE : 12.5 MG / 5 ML PHENIRAMINE MALEATE : 6.25 MG / 5 ML PYRILAMINE MALEATE : 6.25 MG / 5 ML HYDROCODONE BITARTRATE : 1.667 MG / 5 ML · TECHNILAB PHARMA INC. · LIQUID · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is CALDOMINE DH ENFANT?
CALDOMINE DH ENFANT 12.5 MG / 5 ML contains PHENYLPROPANOLAMINE HYDROCHLORIDE : 12.5 MG / 5 ML PHENIRAMINE MALEATE : 6.25 MG / 5 ML PYRILAMINE MALEATE : 6.25 MG / 5 ML HYDROCODONE BITARTRATE : 1.667 MG / 5 ML. It is listed in the Health Canada Drug Product Database under DIN 00550493, held by TECHNILAB PHARMA INC., supplied as LIQUID for ORAL administration. Health Canada currently lists it as cancelled post market, status dated 04-Apr-2001. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
How much does Combinations cost around the world?
Combinations is listed on 4 of the national price registers Nexara ingests. Each country publishes on a different basis, so those figures are not comparable with one another — or with a Canadian wholesale price.
What a market publishes matters more than the number it publishes. Czechia publishes a max producer price (ex-factory); Hungary publishes a producer price (ex-factory); Iceland publishes a max wholesale. Comparing an ex-factory ceiling against a pharmacy public price tells you nothing about either, and comparing either against a Canadian landed cost tells you less.
| Market | Price basis published there | Brands | Packs listed | Range |
|---|---|---|---|---|
| Hungary | producer price (ex-factory) | 5 | 5 | HUF███.██ |
| Czechia | max producer price (ex-factory) | 1 | 1 | CZK███.██ |
| Iceland | max wholesale | 1 | 1 | ISK███.██ |
| Luxembourg | reimbursement | 1 | 1 | EUR███.██ |
8 pack listings across 8 brand entries and 4 price bases, refreshed 05 Sep 2026. Ranges span every Combinations pack in that market, so a high figure is usually a larger pack rather than the same product.
This table is a regulatory record of where the molecule is listed. The DIN on this page is no longer authorized for sale in Canada, so Nexara does not quote it — see the alternatives above.
Is there a generic Combinations in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
61 holders have a Canadian DIN containing Combinations, across 165 DINs, of which 11 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| HALEON CANADA ULC | 5 | 5 | JACK & JILL BEDTIME HONEY COUGH & COLD, JACK & JILL MULTI-SYMPTOM COLD & COUGH, ROBITUSSIN CHILDREN'S COUGH & COLD BEDTIME, ROBITUSSIN CHILDREN'S COUGH AND COLD, ROBITUSSIN HONEY COUGH & COLD NIGHTTIME | Sourceable in Canada |
| PROCTER & GAMBLE INC | 12 | 3 | CHILDREN'S NYQUIL LIQUID, DAYQUIL KIDS, NYQUIL COUGH + COLD, NYQUIL COUGH DM + CONGESTION, NYQUIL KIDS, +7 more | Sourceable in Canada |
| MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC | 11 | 1 | BENYLIN DM WITH PECTIN FREEZER POPS, BENYLIN DM-D, BENYLIN DM-D CHEWABLES FOR CHILDREN, BENYLIN DM-D FOR CHILDREN, BENYLIN DM-D FOR INFANTS, +5 more | Sourceable in Canada |
| TANTA PHARMACEUTICALS INC | 5 | 1 | CHILDREN'S NICOLD MEDICINE, COLDASIDE COUGH & COLD, DM COUGH AND COLD LIQUID, EXTRA STRENGTH DM COUGH AND COLD LIQUID, TANTACOL DM SYR | Sourceable in Canada |
| TEVA CANADA LIMITED | 2 | 1 | RATIO-CALMYDONE, TEVA-COTRIDIN | Sourceable in Canada |
| NOVARTIS CONSUMER HEALTH CANADA INC. | 15 | 0 | NEOCITRAN COLD & COUGH NIGHT, NEOCITRAN COUGH & COLD SYRUP, NEOCITRAN THIN STRIPS DAYTIME COUGH AND COLD, TRIAMINIC COLD & NIGHTTIME COUGH, TRIAMINIC COLD AND COUGH, +10 more | No marketed DIN |
| TECHNILAB PHARMA INC. | 10 | 0 | CALDOMINE DH ADULTE, CALDOMINE DH ENFANT, CALMYLIN #2 SYR, CALMYLIN PEDIATRIC SYRUP, CORISTINE-DH LIQ, +5 more | No marketed DIN |
| JAMP PHARMA CORPORATION | 7 | 0 | COUGH SYRUP DM - DECONGESTANT FOR CHILDREN, COUGH SYRUP DM DECONGESTANT, COUGH SYRUP DM DECONGESTANT FOR CHILDREN, DM COUGH AND COLD SYRUP, EXTRA STRENGTH DM COUGH AND COLD SYRUP, +1 more | No marketed DIN |
| CELLCHEM PHARMACEUTICALS INC. | 6 | 0 | COUGH & COLD, DM COUGH AND COLD LIQUID CHERRY FLAVOUR, DM COUGH AND COLD RELIEF, DRY COUGH & COLD SYRUP, HOT LEMON RELIEF FOR SYMPTOMS OF COUGH AND COLD, +1 more | No marketed DIN |
| WHITEHALL-ROBINS INC. | 6 | 0 | DIMETAPP CHILDREN'S COUGH AND COLD LIQUID, DIMETAPP COUGH & COLD LIQUI-GELS - CAP, DIMETAPP DM ELIXIR, DIMETAPP DM TAB, DIMETAPP-C SYR, +1 more | No marketed DIN |
| THE BUCKLEY'S COMPANY | 5 | 0 | BUCKLEY'S DM DECONGESTANT, JACK & JILL BEDTIME MULTI-SYMPTOM COLD & COUGH, JACK & JILL CHILDREN'S FORMULA COUGH LIQUID, JACK & JILL COUGH & COLD, JACK & JILL COUGH AND COLD | No marketed DIN |
| PRODEMDIS ENR. | 4 | 0 | ANTITUSSIVE DECONG ANTIHISTAMINE SYR, CITRON CHAUD DM CUMBERLAND PWS, CITRON CHAUD DM OPTION + PWS, DM COUGH SYRUP | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 12.5 MG / 5 ML |
|---|---|
| Dosage form | LIQUID |
| Route | ORAL |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Combinations |
|---|---|
| ATC code | R05DA20 |
| AHFS class | 48:08.00 ; 04:04.00 ; 04:04.20 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 00550493 |
|---|---|
| DIN (unpadded, as printed on some documents) | 550493 |
| Brand name | CALDOMINE DH ENFANT |
| Generic / active ingredient | PHENYLPROPANOLAMINE HYDROCHLORIDE : 12.5 MG / 5 ML PHENIRAMINE MALEATE : 6.25 MG / 5 ML PYRILAMINE MALEATE : 6.25 MG / 5 ML HYDROCODONE BITARTRATE : 1.667 MG / 5 ML |
| Market authorization holder | TECHNILAB PHARMA INC. |
| Health Canada schedule | NARCOTICS (CDSA I) |
| ATC code | R05DA20 |
| ATC anatomical main group | R — Respiratory system |
| ATC therapeutic subgroup | R05DA |
| Current status | CANCELLED POST MARKET |
| Status date | 04-Apr-2001 |
| Original market date | 1982-12-31 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
11 of 165 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| BENYLIN FOR CHILDREN COUGH & COLD | 7.5 MG / 5 ML | SYRUP | MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC | MARKETED | 01944746 |
| COLDASIDE COUGH & COLD | 4 MG | TABLET | TANTA PHARMACEUTICALS INC | MARKETED | 02309440 |
| JACK & JILL BEDTIME HONEY COUGH & COLD | 7.5 MG / 5 ML | SYRUP | HALEON CANADA ULC | MARKETED | 02522969 |
| JACK & JILL MULTI-SYMPTOM COLD & COUGH | 7.5 MG / 5 ML | SYRUP | HALEON CANADA ULC | MARKETED | 02533626 |
| NYQUIL COUGH DM + CONGESTION | 6.25 MG / 15 ML | SYRUP | PROCTER & GAMBLE INC | MARKETED | 02503611 |
| NYQUIL KIDS | 5 MG / 15 ML | SYRUP | PROCTER & GAMBLE INC | MARKETED | 02520419 |
| NYQUIL KIDS COUGH & COLD | 2 MG / 15 ML | SYRUP | PROCTER & GAMBLE INC | MARKETED | 02273330 |
| ROBITUSSIN CHILDREN'S COUGH & COLD BEDTIME | 5 MG / 5 ML | SYRUP | HALEON CANADA ULC | MARKETED | 02394707 |
| ROBITUSSIN CHILDREN'S COUGH AND COLD | 7.5 MG / 5 ML | SYRUP | HALEON CANADA ULC | MARKETED | 02044013 |
| ROBITUSSIN HONEY COUGH & COLD NIGHTTIME | 12.5 MG / 20 ML | SYRUP | HALEON CANADA ULC | MARKETED | 02485443 |
2 · Same class — other molecules in ATC R05DA
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Combinations | ACTIFED DM SYRUP · ACTIFED DM TABLETS · ANTITUSSIVE DECONG ANTIHISTAMINE SYR · BALMINIL DM + DECONGESTANT · +146 more | 165 | 11 | Yes |
| Dextromethorphan | ADULT HONEY WORKS · BALMINIL DM · BALMINIL DM (3MG/ML SUCROSE FREE) · BALMINIL DM CHILDREN · +75 more | 84 | 10 | Yes |
| Codeine | CODEINE 15 · CODEINE 30 · CODEINE CONTIN 100MG CONTROLLED RELEASE TAB · CODEINE CONTIN 150MG CONTROLLED RELEASE TAB · +17 more | 24 | 9 | Yes |
| Hydrocodone | HYCODAN SYRUP · HYCODAN TABLETS · PDP-HYDROCODONE · ROBIDONE 1MG/ML SYR · +1 more | 5 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC R05D
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| R05DB | Clofedanol | 1 | 1 |
4 · Fixed-dose combinations with Canadian supply
| Product | Active ingredients | Holder | Status | DIN |
|---|---|---|---|---|
| CODEINE CONTIN 100MG CONTROLLED RELEASE TAB | CODEINE (CODEINE MONOHYDRATE, CODEINE SULFATE TRIHYDRATE) : 100 MG | PURDUE PHARMA | MARKETED | 02163748 |
| CODEINE CONTIN 150MG CONTROLLED RELEASE TAB | CODEINE (CODEINE MONOHYDRATE, CODEINE SULFATE TRIHYDRATE) : 150 MG | PURDUE PHARMA | MARKETED | 02163780 |
| CODEINE CONTIN 200MG CONTROLLED RELEASE TAB | CODEINE (CODEINE MONOHYDRATE, CODEINE SULFATE TRIHYDRATE) : 200 MG | PURDUE PHARMA | MARKETED | 02163799 |
| CODEINE CONTIN 50MG CONTROLLED RELEASE TAB | CODEINE (CODEINE MONOHYDRATE, CODEINE SULFATE TRIHYDRATE) : 50 MG | PURDUE PHARMA | MARKETED | 02230302 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
What else is CALDOMINE DH ENFANT called?
The same molecule, Combinations, is registered under other names elsewhere. Buyers and prescribers searching from outside Canada — or working from a foreign prescription or tender document — often know it by one of these:
| Name | Script | Registered in |
|---|---|---|
| Ekyflogyl | Latin | Iceland |
| OTIPAX | Latin | Czechia |
Names are taken from national medicine registers and published price lists. A product registered abroad is not authorized for sale in Canada unless it holds its own DIN; import is possible only through the routes Health Canada permits.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.