WINRHO SDF 1500 UNIT — DIN 02217449
ANTI-D (RH) IMMUNOGLOBULIN (HUMAN) : 1500 UNIT · APTEVO BIOTHERAPEUTICS LLC · KIT · wholesale supply in Canada
Health Canada status: CANCELLED POST MARKET
What is WINRHO SDF?
WINRHO SDF 1500 UNIT contains ANTI-D (RH) IMMUNOGLOBULIN (HUMAN) : 1500 UNIT. It is listed in the Health Canada Drug Product Database under DIN 02217449, held by APTEVO BIOTHERAPEUTICS LLC, supplied as KIT for INTRAVENOUS ; INTRAMUSCULAR administration. Health Canada currently lists it as cancelled post market, status dated 15-Jul-2016. This Drug Identification Number is no longer authorized for sale in Canada, so Nexara does not supply it. The record is kept here because buyers still meet the number on old formularies, purchase orders and tender documents; Nexara can help identify an authorized alternative.
What is WINRHO SDF used for?
WinRho® SDF is indicated for the prevention of Rh immunization in Rh o (D) negative mothers not previously sensitized to the Rh o (D) factor, and to prevent alloimmunization in Rh o (D) negative female children and female adults in their child-bearing years transfused with Rh o (D) positive RBCs or blood components with Rh o (D) positive RBCs. It is also recommended in the treatment of destructive thrombocytopenia of an immune etiology in situations where platelet counts must be increased to control bleeding, specifically for non-splenectomized Rh o (D) positive children with chronic or acute ITP, adults with chronic ITP, or children and adults with ITP secondary to HIV infection.
Authorized indication as written in the Health Canada product monograph. For healthcare professionals and licensed purchasers; this is not medical advice.
Is there a generic Anti-D (Rh) Immunoglobulin in Canada, and who makes it?
Every market authorization holder with a Canadian DIN for this molecule, and how many of their listings Health Canada currently shows as marketed.
4 holders have a Canadian DIN containing Anti-D (Rh) Immunoglobulin, across 11 DINs, of which 2 are currently marketed. Marketed count is the number that matters: an approval that is not marketed cannot be bought.
| Market authorization holder | DINs | Marketed | Brand names | Position |
|---|---|---|---|---|
| KI BIOPHARMA LLC | 5 | 2 | WINRHO SDF | Sourceable in Canada |
| APTEVO BIOTHERAPEUTICS LLC | 3 | 0 | WINRHO SDF | No marketed DIN |
| RH PHARMACEUTICALS INC. | 2 | 0 | WINRHO SD KIT INJ, WINRHO SD KIT INJ. | No marketed DIN |
| CUTTER MED & BIOL, DIVISION OF MILES CANADA LTD. | 1 | 0 | HYP RHO D INJ 16.5% | No marketed DIN |
Health Canada’s Drug Product Database does not flag which listing is the originator and which are subsequent-entry products, so Nexara does not label them here. Interchangeability is determined provincially, not federally — confirm for your province before a formulary switch. Nexara can confirm which of these is actually obtainable, and on what lead time, per order.
How is it supplied and stored?
Pack configuration, storage class and the handling constraints that drive cold-chain planning. One DIN can cover more than one pack size, and the pack — not the DIN — is what gets priced, shipped and invoiced.
| Strength on the label | 1500 UNIT |
|---|---|
| Dosage form | KIT |
| Route | INTRAVENOUS ; INTRAMUSCULAR |
| Pack configuration (monograph) | Lyophilized: 600 IU (120 μg), 1500 IU (300 μg), 5000 IU ( 1000 μg) Liquid: 600 IU (120 μg), 1500 IU (300 μg), 2500 IU (500 μg), 5000 IU (1000 μg), 15 000 IU (3000 μg) |
| Storage | null |
Pack detail is kept as a regulatory record. This DIN is no longer authorized for sale in Canada, so Nexara does not quote this pack.
Substance and classification
| Active substance | Anti-D (Rh) Immunoglobulin |
|---|---|
| ATC code | J06BB01 |
| AHFS class | 80:04.00 |
| Biosimilar biologic | No |
Health Canada record and identifiers
The regulatory facts straight from the Drug Product Database, plus every identifier form Nexara accepts on a purchase order. A DIN written without its leading zeros is the commonest reason an order line fails to match.
| DIN (8-digit, as used in ordering) | 02217449 |
|---|---|
| DIN (unpadded, as printed on some documents) | 2217449 |
| Brand name | WINRHO SDF |
| Generic / active ingredient | ANTI-D (RH) IMMUNOGLOBULIN (HUMAN) : 1500 UNIT |
| Market authorization holder | APTEVO BIOTHERAPEUTICS LLC |
| Health Canada schedule | Schedule D |
| ATC code | J06BB01 |
| ATC anatomical main group | J — Anti-infectives for systemic use |
| ATC therapeutic subgroup | J06BB |
| Current status | CANCELLED POST MARKET |
| Status date | 15-Jul-2016 |
| Original market date | 1996-08-28 00:00:00 |
| Status source | Live Health Canada DPD sync |
Verify on the primary sources
How is it administered?
ITP: 250 IU/kg (50 μg/kg) IV; if Hb <10 g/dL, reduce to 125-200 IU/kg. Pregnancy: 1500 IU (300 μg) at 28 weeks and within 72 hours of delivery. Administer IV for ITP; IV or IM for prophylaxis.
Included because it drives pack selection and wastage. Consult the monograph.
Contraindications
Rh(D) positive patients (for prophylaxis); Rh(D) negative or splenectomized patients (for ITP); IgA deficiency; history of anaphylaxis to human immune globulins; hypersensitivity to any ingredient.
Warnings and precautions
Serious risk of intravascular hemolysis (IVH) and complications (anemia, renal failure, DIC) in ITP treatment. Monitor ITP patients for 8 hours post-infusion. Risk of viral transmission.
What can be used instead?
Alternatives on every axis a buyer actually considers — the same molecule in another presentation, the same class, an adjacent class, or a fixed-dose combination. Every row is led by the marketed DIN count, because that is what can be bought this week.
1 · Same molecule, other Canadian presentations
2 of 11 Canadian DINs for this molecule are currently marketed. Marketed products are listed first.
| Product | Strength | Form | Holder | Health Canada status | DIN |
|---|---|---|---|---|---|
| WINRHO SDF | 600 UNIT | SOLUTION | KI BIOPHARMA LLC | MARKETED | 02302551 |
| WINRHO SDF | 1500 UNIT | SOLUTION | KI BIOPHARMA LLC | MARKETED | 02302578 |
| HYP RHO D INJ 16.5% | 16.5 % | LIQUID | CUTTER MED & BIOL, DIVISION OF MILES CANADA LTD. | CANCELLED POST MARKET | 00083267 |
| WINRHO SD KIT INJ | 120 MCG | KIT | RH PHARMACEUTICALS INC. | CANCELLED POST MARKET | 02022842 |
| WINRHO SD KIT INJ. | .9 % | KIT | RH PHARMACEUTICALS INC. | CANCELLED POST MARKET | 02022834 |
| WINRHO SDF | 5000 UNIT | KIT | APTEVO BIOTHERAPEUTICS LLC | CANCELLED POST MARKET | 02230397 |
| WINRHO SDF | 600 UNIT | KIT | APTEVO BIOTHERAPEUTICS LLC | CANCELLED POST MARKET | 02217430 |
| WINRHO SDF | 2500 UNIT | SOLUTION | KI BIOPHARMA LLC | APPROVED | 02302586 |
| WINRHO SDF | 5000 UNIT | SOLUTION | KI BIOPHARMA LLC | DORMANT | 02302594 |
| WINRHO SDF | 15000 UNIT | SOLUTION | KI BIOPHARMA LLC | APPROVED | 02302608 |
2 · Same class — other molecules in ATC J06BB
| Molecule | Canadian brands | DINs | Marketed | Sourceable |
|---|---|---|---|---|
| Hepatitis B Immunoglobulin | H-BIG · HEPAGAM B · HYPERHEP B · HYPERHEP B S/D · +1 more | 9 | 3 | Yes |
| Anti-D (Rh) Immunoglobulin | HYP RHO D INJ 16.5% · WINRHO SD KIT INJ · WINRHO SD KIT INJ. · WINRHO SDF | 11 | 2 | Yes |
| Rabies Immunoglobulin | HYPERAB RABIES IMMUNE GLOBULIN HUMAN · HYPERRAB · HYPERRAB S/D · IMOGAM RABIES INJ 150UNIT/ML · +2 more | 7 | 2 | Yes |
| Tetanus Immunoglobulin | HYPER TET · HYPERTET · HYPERTET S/D | 4 | 1 | Yes |
| Varicella/Zoster Immunoglobulin | VARICELLA ZOSTER IMMUNE GLOBULIN INJ · VARICELLA-ZOSTER IMMUNE GLOBULIN (HUMAN) · VARIZIG | 4 | 1 | Yes |
| Cytomegalovirus Immunoglobulin | CYTOGAM | 1 | 1 | Yes |
A molecule with zero marketed DINs cannot be sourced domestically, however many approvals it holds — if one of these sits on a formulary or in an older protocol, that is the line to check.
3 · Adjacent classes in ATC J06B
| ATC subgroup | Molecules | DINs | Marketed |
|---|---|---|---|
| J06BA | Immunoglobulins, Normal Human, For Extravasc. Adm · Immunoglobulins, Normal Human, For Intravasc. Adm. | 50 | 16 |
| J06BD | Casirivimab And Imdevimab · Nirsevimab · Palivizumab · Sipavibart · Sotrovimab · +1 more | 11 | 2 |
| J06B | Immunoglobulins | 1 | 0 |
Not clinical advice. These tables describe what can be supplied in Canada, not what should be prescribed. Substitution within or across classes is a prescriber and pharmacist decision, and interchangeability is determined provincially.
Can this still be bought in Canada?
No. This Drug Identification Number is cancelled post market in Health Canada's Drug Product Database, so the product is no longer authorized for sale in Canada and Nexara does not supply it. This page is kept as a regulatory record.
If you are looking for a current equivalent, the alternatives above list every product sharing this therapeutic class, with the marketed ones first. Ask us to source an alternative
Ordering questions
Who can buy this from Nexara?
Licensed entities only. Nexara holds Health Canada establishment licence DEL 3-002896-A and ships only to a licensed address. Patients and unlicensed buyers are routed to a partner pharmacy.
Is there a minimum order?
Yes, set per product line and per pack multiple rather than on the order total, so you are never asked to buy a part-pack. The minimum for this line is confirmed with your quote.
What is the lead time?
Confirmed per order at quotation, and it depends on current stock position and whether the product is in shortage.
Why is there no price on this page?
Nexara quotes a delivered Canadian price per order, against a verified licence. Foreign list prices are published on incompatible bases and are not a guide to what any buyer can obtain here, so this page shows which markets list the molecule and on what basis, and nothing more.
Can Nexara supply this for a clinical trial?
Yes — comparator and background-therapy supply, including sourcing from other markets where a Canadian pack will not satisfy the protocol. Clinical trial supply.